MTCOSB's profile picture. たぶん腫瘍内科医です。

じなん

@MTCOSB

たぶん腫瘍内科医です。

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【備忘】今年書く論文 ・CIPNの前向き臨床試験 ・頭頚部 DEK-AFF2 case ・頭頚部 pembro レトロ ・頭頚部 RET fusion cases ・アナモレリン x 腸内細菌


別にいいんやけども、弊社の電子カルテのパソコン、「から」って入力したら真っ先に「からかい上手の高木さん」を予測変換に出してくるんよね。別にいいんやけども。


じなん reposted

「絶食や炎症で身体が弱ったときにマウスがアミノ酸の含まれる食品だけを忌避するという行動のメカニズムを解析した研究」 身体が弱るとアミノ酸を避ける(11月4日 Cell オンライン掲載論文)aasj.jp/news/watch/277…


外来で患者さんから「今日の探偵ナイトスクープに出るので見てください!」って言われたんだけど、この番組まだやってたんやなあ。。。 asahi.co.jp/knight-scoop/


がん原発巣を切除したら急に転移巣が活発になる、という「親の仇討ち現象(こんな名前はない)」っていうのはやっぱりお互いがクロストークしてる結果なんだろうか、知らんけども。現象としては興味深いけど臨床医としてはたまったもんではない。


在宅化学療法の臨床試験とかできるんかなあ。。。(少なくとも自分はできない) 皮下注ケモになったら外来ケモより在宅ケモへの移行が進むのかどうか?


今年通った論文を振り返ると、 ・免疫チェックポイント阻害薬の効果と血液型の関係 ・アナモレリンが腸内細菌叢に影響するか ・シイタケ成分でしびれを軽減するか ・症例報告(ゲノムと免疫チェックポイント阻害薬) ということで、テーマだけ見るとなんか夏休みの自由研究かいというところはある🥹


じなん reposted

ChatGPTの忖度を防ぐためのカスタムインストラクション

genkAIjokyo's tweet image. ChatGPTの忖度を防ぐためのカスタムインストラクション

ランマークが免疫療法の効果と副作用に影響するっていや待てなんせ絵のセンス

🦴🧬 Denosumab + Pembrolizumab in Breast Cancer? A Synergistic Story with a Price! 👩‍🦰 425 female pts with breast cancer on pembrolizumab were analyzed: 🔹 Denosumab (n=55) 🔹 Zoledronic acid (n=31) 🔹 No BMA (n=339) 🧩 Severe irAE (Grade ≥3) •Denosumab: 21.8% •Zoledronic…

DrRishabhOnco's tweet image. 🦴🧬 Denosumab + Pembrolizumab in Breast Cancer? A Synergistic Story with a Price!

👩‍🦰 425 female pts with breast cancer on pembrolizumab were analyzed:
🔹 Denosumab (n=55)
🔹 Zoledronic acid (n=31)
🔹 No BMA (n=339)

🧩 Severe irAE (Grade ≥3)
•Denosumab: 21.8%
•Zoledronic…


202511 ESMO Open FGFR2bからFGFR2cへのアイソフォームスイッチングが治療抵抗性ならびに悪性形質(EMT)と関連する、MONSTAR-SCREEN-2からの解析 橋本先生、おめでとうございます! sciencedirect.com/science/articl…


じなん reposted

🇪🇺 ESGO–ESTRO–ESP 2025 GUIDELINES UPDATE 🔹 Core Update 2023 FIGO staging + Molecular classification (POLEmut / MMRd / NSMP / p53abn) ➡️ Biology now defines stage, risk & therapy 🧪 Universal Testing ✅ MMR IHC ± MLH1 methylation → all ECs 🔍 POLE, p53, ER, HER2 testing →…

DrRishabhOnco's tweet image. 🇪🇺 ESGO–ESTRO–ESP 2025 GUIDELINES UPDATE

🔹 Core Update
2023 FIGO staging + Molecular classification (POLEmut / MMRd / NSMP / p53abn)
➡️ Biology now defines stage, risk & therapy

🧪 Universal Testing
✅ MMR IHC ± MLH1 methylation → all ECs
🔍 POLE, p53, ER, HER2 testing →…
DrRishabhOnco's tweet image. 🇪🇺 ESGO–ESTRO–ESP 2025 GUIDELINES UPDATE

🔹 Core Update
2023 FIGO staging + Molecular classification (POLEmut / MMRd / NSMP / p53abn)
➡️ Biology now defines stage, risk & therapy

🧪 Universal Testing
✅ MMR IHC ± MLH1 methylation → all ECs
🔍 POLE, p53, ER, HER2 testing →…
DrRishabhOnco's tweet image. 🇪🇺 ESGO–ESTRO–ESP 2025 GUIDELINES UPDATE

🔹 Core Update
2023 FIGO staging + Molecular classification (POLEmut / MMRd / NSMP / p53abn)
➡️ Biology now defines stage, risk & therapy

🧪 Universal Testing
✅ MMR IHC ± MLH1 methylation → all ECs
🔍 POLE, p53, ER, HER2 testing →…

びみょいな #ESMO25

#ESMO25 FORTITUDE-101 (Ph III): BEMA + mFOLFOX6 vs placebo in FGFR2b+ GC/GEJ ⏱️ mOS 17.9 vs 12.5 mo (HR 0.61; p=0.005) | mPFS 8.6 vs 6.7 mo (HR 0.71; p=0.019) 👁️ Gr≥3 AEs mainly corneal (33%) ⚖️ OS benefit reduced at longer follow-up — 1st anti-FGFR2b mAb with OS gain @OncoAlert

DraMartinezLago's tweet image. #ESMO25
FORTITUDE-101 (Ph III): BEMA + mFOLFOX6 vs placebo in FGFR2b+ GC/GEJ
⏱️ mOS 17.9 vs 12.5 mo (HR 0.61; p=0.005) | mPFS 8.6 vs 6.7 mo (HR 0.71; p=0.019)
👁️ Gr≥3 AEs mainly corneal (33%)
⚖️ OS benefit reduced at longer follow-up — 1st anti-FGFR2b mAb with OS gain
@OncoAlert…
DraMartinezLago's tweet image. #ESMO25
FORTITUDE-101 (Ph III): BEMA + mFOLFOX6 vs placebo in FGFR2b+ GC/GEJ
⏱️ mOS 17.9 vs 12.5 mo (HR 0.61; p=0.005) | mPFS 8.6 vs 6.7 mo (HR 0.71; p=0.019)
👁️ Gr≥3 AEs mainly corneal (33%)
⚖️ OS benefit reduced at longer follow-up — 1st anti-FGFR2b mAb with OS gain
@OncoAlert…
DraMartinezLago's tweet image. #ESMO25
FORTITUDE-101 (Ph III): BEMA + mFOLFOX6 vs placebo in FGFR2b+ GC/GEJ
⏱️ mOS 17.9 vs 12.5 mo (HR 0.61; p=0.005) | mPFS 8.6 vs 6.7 mo (HR 0.71; p=0.019)
👁️ Gr≥3 AEs mainly corneal (33%)
⚖️ OS benefit reduced at longer follow-up — 1st anti-FGFR2b mAb with OS gain
@OncoAlert…
DraMartinezLago's tweet image. #ESMO25
FORTITUDE-101 (Ph III): BEMA + mFOLFOX6 vs placebo in FGFR2b+ GC/GEJ
⏱️ mOS 17.9 vs 12.5 mo (HR 0.61; p=0.005) | mPFS 8.6 vs 6.7 mo (HR 0.71; p=0.019)
👁️ Gr≥3 AEs mainly corneal (33%)
⚖️ OS benefit reduced at longer follow-up — 1st anti-FGFR2b mAb with OS gain
@OncoAlert…


じなん reposted

🆙#ESMO25🇩🇪 🔥#LCSM Mini Oral, non-mets, SCLC ☑️Updated results from a phase I/II study of gocatamig for small cell lung cancer (SCLC) and other neuroendocrine cancers ☑️ORR 44%, DCR 66% 🎙️ Dr. Himisha Beltran @OncoAlert @myESMO @Larvol

HHorinouchi's tweet image. 🆙#ESMO25🇩🇪
🔥#LCSM Mini Oral, non-mets, SCLC
☑️Updated results from a phase I/II study of gocatamig for small cell lung cancer (SCLC) and other neuroendocrine cancers
☑️ORR 44%, DCR 66%
🎙️ Dr. Himisha Beltran
@OncoAlert @myESMO @Larvol
HHorinouchi's tweet image. 🆙#ESMO25🇩🇪
🔥#LCSM Mini Oral, non-mets, SCLC
☑️Updated results from a phase I/II study of gocatamig for small cell lung cancer (SCLC) and other neuroendocrine cancers
☑️ORR 44%, DCR 66%
🎙️ Dr. Himisha Beltran
@OncoAlert @myESMO @Larvol
HHorinouchi's tweet image. 🆙#ESMO25🇩🇪
🔥#LCSM Mini Oral, non-mets, SCLC
☑️Updated results from a phase I/II study of gocatamig for small cell lung cancer (SCLC) and other neuroendocrine cancers
☑️ORR 44%, DCR 66%
🎙️ Dr. Himisha Beltran
@OncoAlert @myESMO @Larvol
HHorinouchi's tweet image. 🆙#ESMO25🇩🇪
🔥#LCSM Mini Oral, non-mets, SCLC
☑️Updated results from a phase I/II study of gocatamig for small cell lung cancer (SCLC) and other neuroendocrine cancers
☑️ORR 44%, DCR 66%
🎙️ Dr. Himisha Beltran
@OncoAlert @myESMO @Larvol

【ケモ室界隈の人に聞きたい】 ESMOもJSCOもいいけども、目下の悩みはPSが悪い人の外来ケモが増えすぎてるんよなあ… 外来ケモ室での家族の役割、どうしてます? コメントもお待ちしてます


じなん reposted

【先週よく読まれた記事】 トラスツズマブ デルクステカン(T-DXd)の後治療に関するリアルワールドデータ こちらの記事が人気です。まだの先生はぜひご覧ください。 clinpeer.medpeer.jp/media/assets/2… ↑「記事」からチェック! #ClinPeer


胸腺が元気なら免疫療法が効く 腸活の次は胸(腺)活しろと…?🤔

A new perspective: the key to immunotherapy success may lie in the thymus at #esmo25 Abstract 108O— thymic health, measured via deep learning on routine CT scans, is strongly linked to immunotherapy outcomes. In a pan-cancer cohort of 3,476 patients: ✅Higher thymic health →…

Dr_ElvinaA's tweet image. A new perspective: the key to immunotherapy success may lie in the thymus at #esmo25 

Abstract 108O— thymic health, measured via deep learning on routine CT scans, is strongly linked to immunotherapy outcomes.

In a pan-cancer cohort of 3,476 patients:
✅Higher thymic health →…
Dr_ElvinaA's tweet image. A new perspective: the key to immunotherapy success may lie in the thymus at #esmo25 

Abstract 108O— thymic health, measured via deep learning on routine CT scans, is strongly linked to immunotherapy outcomes.

In a pan-cancer cohort of 3,476 patients:
✅Higher thymic health →…


LEAP-015(胃癌)に続いて014(食道癌)もnegative LEN+PEMはこれで白黒ついたかな

📢LEAP-014 Upper GI proffered #ESMO25 ➡️Met esophageal SCC ➡️1L pembro-lenva-ChT vs pembro-ChT ❌Negative trial #cancer #oncology #MedX #GI #gastrointestinal @OncoAlert @weoncologists

Erman_Akkus's tweet image. 📢LEAP-014 
Upper GI proffered #ESMO25

➡️Met esophageal SCC
➡️1L pembro-lenva-ChT vs pembro-ChT

❌Negative trial

#cancer #oncology #MedX #GI #gastrointestinal @OncoAlert @weoncologists
Erman_Akkus's tweet image. 📢LEAP-014 
Upper GI proffered #ESMO25

➡️Met esophageal SCC
➡️1L pembro-lenva-ChT vs pembro-ChT

❌Negative trial

#cancer #oncology #MedX #GI #gastrointestinal @OncoAlert @weoncologists
Erman_Akkus's tweet image. 📢LEAP-014 
Upper GI proffered #ESMO25

➡️Met esophageal SCC
➡️1L pembro-lenva-ChT vs pembro-ChT

❌Negative trial

#cancer #oncology #MedX #GI #gastrointestinal @OncoAlert @weoncologists


Node negative どうする問題勃発

#ESMO25 | #UpperGI MATTERHORN confirms what the abstract hinted. ✅Positive study for OS! BUT, 🔹 In PD-L1 TAP <1% (HR 0.79; 95% CI 0.41–1.50) ➡️ No clear benefit observed Consistent with prior metastatic data—PD-L1 negative patients remain unlikely to derive meaningful…

GIMedOnc's tweet image. #ESMO25 | #UpperGI

MATTERHORN confirms what the abstract hinted.

✅Positive study for OS!

BUT,

🔹 In PD-L1 TAP &amp;lt;1% (HR 0.79; 95% CI 0.41–1.50)
➡️ No clear benefit observed

Consistent with prior metastatic data—PD-L1 negative patients remain unlikely to derive meaningful…
GIMedOnc's tweet image. #ESMO25 | #UpperGI

MATTERHORN confirms what the abstract hinted.

✅Positive study for OS!

BUT,

🔹 In PD-L1 TAP &amp;lt;1% (HR 0.79; 95% CI 0.41–1.50)
➡️ No clear benefit observed

Consistent with prior metastatic data—PD-L1 negative patients remain unlikely to derive meaningful…


チラゴルマブ、アテゾの邪魔してる感すらある…

📢SKYSCRAPER-07 Upper GI proffered #ESMO25 ➡️Locally advanced esophageal SCC ➡️Following dCRT, Atezo-tiroglumab vs atezo-plecebo vs double placebo ❌No benefit with tiroglumab ✅ Atezo vs placebo PFS: HR 0.74 (0.58–0.93), p=0.011 OS: HR 0.69 (0.52–0.91), p=0.008 #cancer

Erman_Akkus's tweet image. 📢SKYSCRAPER-07
Upper GI proffered #ESMO25

➡️Locally advanced esophageal SCC
➡️Following dCRT,
Atezo-tiroglumab vs atezo-plecebo vs double placebo

❌No benefit with tiroglumab
✅ Atezo vs placebo
PFS: HR 0.74 (0.58–0.93), p=0.011
OS: HR 0.69 (0.52–0.91), p=0.008

#cancer…
Erman_Akkus's tweet image. 📢SKYSCRAPER-07
Upper GI proffered #ESMO25

➡️Locally advanced esophageal SCC
➡️Following dCRT,
Atezo-tiroglumab vs atezo-plecebo vs double placebo

❌No benefit with tiroglumab
✅ Atezo vs placebo
PFS: HR 0.74 (0.58–0.93), p=0.011
OS: HR 0.69 (0.52–0.91), p=0.008

#cancer…
Erman_Akkus's tweet image. 📢SKYSCRAPER-07
Upper GI proffered #ESMO25

➡️Locally advanced esophageal SCC
➡️Following dCRT,
Atezo-tiroglumab vs atezo-plecebo vs double placebo

❌No benefit with tiroglumab
✅ Atezo vs placebo
PFS: HR 0.74 (0.58–0.93), p=0.011
OS: HR 0.69 (0.52–0.91), p=0.008

#cancer…
Erman_Akkus's tweet image. 📢SKYSCRAPER-07
Upper GI proffered #ESMO25

➡️Locally advanced esophageal SCC
➡️Following dCRT,
Atezo-tiroglumab vs atezo-plecebo vs double placebo

❌No benefit with tiroglumab
✅ Atezo vs placebo
PFS: HR 0.74 (0.58–0.93), p=0.011
OS: HR 0.69 (0.52–0.91), p=0.008

#cancer…


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