Muir_Lab's profile picture. (Extra)Cellular Cancer Biology @UChicagoCCB.

Muir Lab

@Muir_Lab

(Extra)Cellular Cancer Biology @UChicagoCCB.

Muir Lab reposted

New @CR_AACR study by @Cosimo_Commisso The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in #PancreaticCancer aacrjournals.org/cancerres/arti…

Aiims1742's tweet image. New @CR_AACR study by @Cosimo_Commisso 
The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in #PancreaticCancer
aacrjournals.org/cancerres/arti…

Muir Lab reposted

🗽Save the date! March 24, 2026 Cancer Metabolism and Signaling Symposium @NYASciences co-organized by @LyssiotisLab @RichPossemato Speakers: @lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana Josh R, Erika P +short talks from abstracts!


Muir Lab reposted

Happy to share our new review (featuring Joe Longo and McLane Watson) on how T cells use nutrient allocation to optimize immune responses. @VAIMetabolism @VAInstitute sciencedirect.com/science/articl…


Muir Lab reposted

Big news from the #Glytsoulab today!✍️Our research on drug resistance in leukemia is published in @ScienceAdvances. Targeting OPA1 can help overcome therapy resistance in AML, including the most challenging cases. 📖 science.org/doi/10.1126/sc…


Muir Lab reposted

Our new work in @Cell_Metabolism by @ArtemAKhan describes three new SLC transporters, including SLC25A45, a mitochondrial transporter for methylated amino acids that is essential for carnitine synthesis and fasting adaptation. @RockefellerUniv cell.com/cell-metabolis…


Muir Lab reposted

This cool @ScienceMagazine paper links extracellular pH milieu (acidosis) to an intra-cellular oncogenic signaling pathway & metabolic rewiring in #PancreaticCancer. Acidosis orchestrates adaptations of energy metabolism in tumors science.org/doi/10.1126/sc…

Aiims1742's tweet image. This cool @ScienceMagazine paper links extracellular pH milieu (acidosis) to an intra-cellular oncogenic signaling pathway & metabolic rewiring in #PancreaticCancer.
Acidosis orchestrates adaptations of energy metabolism in tumors
science.org/doi/10.1126/sc…

Muir Lab reposted

Wonderful talk by @DebVendramini @HenryFordHealth on adaptation & plasticity of the stromal and #CancerAssociatedFibroblasts microenvironment in driving immune suppression in #PDAC #AACRPan25 @RAFrancescone

DrJashDatta's tweet image. Wonderful talk by @DebVendramini @HenryFordHealth on adaptation & plasticity of the stromal and #CancerAssociatedFibroblasts microenvironment in driving immune suppression in #PDAC #AACRPan25 @RAFrancescone

Muir Lab reposted

Location, location, location! Now out in @NatureCancer, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation in pancreatic cancer as a clin. relevant example: nature.com/articles/s4301…. (1/3)


Muir Lab reposted

Excited to share the lab’s first pre-print! Here we investigate how #nutrient availability regulates #ECM composition, mechanical properties and biological activity. biorxiv.org/content/10.110…


Muir Lab reposted

Check out the most recent work from @ColinSh21573670 and the Muir Lab!! Super exciting stuff!

Super excited to share our new preprint from @ColinSh21573670 on how the tumor microenvironment causes drug resistance in pancreatic cancer: biorxiv.org/content/10.110…



Muir Lab reposted

Congrats! @Sunhee_Jung_ @HosungBae Wonsuk and co-authors. We reported in this @NatMetabolism intriguing effects of dietary inulin on changing small intestinal gut microbial fructose metabolism, leading to protective effects on liver. Thanks, reviewers. nature.com/articles/s4225…


Muir Lab reposted

The gloriously atmospheric interior of Powell's Bookstore in Hyde Park, Chicago

Furmadamadam's tweet image. The gloriously atmospheric interior of Powell's Bookstore in Hyde Park, Chicago
Furmadamadam's tweet image. The gloriously atmospheric interior of Powell's Bookstore in Hyde Park, Chicago
Furmadamadam's tweet image. The gloriously atmospheric interior of Powell's Bookstore in Hyde Park, Chicago

Muir Lab reposted

New study alert! Coming out today @ImmunityCP, we describe crosstalk between dysfunctional mitochondria and telomere damage in the context of tumor-induced T cell dysfunction. I'll tell you how we did it: cell.com/immunity/fullt… 1/


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