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New @CR_AACR study by @Cosimo_Commisso The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in #PancreaticCancer aacrjournals.org/cancerres/arti…
🗽Save the date! March 24, 2026 Cancer Metabolism and Signaling Symposium @NYASciences co-organized by @LyssiotisLab @RichPossemato Speakers: @lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana Josh R, Erika P +short talks from abstracts!
Happy to share our new review (featuring Joe Longo and McLane Watson) on how T cells use nutrient allocation to optimize immune responses. @VAIMetabolism @VAInstitute sciencedirect.com/science/articl…
Big news from the #Glytsoulab today!✍️Our research on drug resistance in leukemia is published in @ScienceAdvances. Targeting OPA1 can help overcome therapy resistance in AML, including the most challenging cases. 📖 science.org/doi/10.1126/sc…
Our new work in @Cell_Metabolism by @ArtemAKhan describes three new SLC transporters, including SLC25A45, a mitochondrial transporter for methylated amino acids that is essential for carnitine synthesis and fasting adaptation. @RockefellerUniv cell.com/cell-metabolis…
This cool @ScienceMagazine paper links extracellular pH milieu (acidosis) to an intra-cellular oncogenic signaling pathway & metabolic rewiring in #PancreaticCancer. Acidosis orchestrates adaptations of energy metabolism in tumors science.org/doi/10.1126/sc…
Wonderful talk by @DebVendramini @HenryFordHealth on adaptation & plasticity of the stromal and #CancerAssociatedFibroblasts microenvironment in driving immune suppression in #PDAC #AACRPan25 @RAFrancescone
Location, location, location! Now out in @NatureCancer, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation in pancreatic cancer as a clin. relevant example: nature.com/articles/s4301…. (1/3)
Excited to share the lab’s first pre-print! Here we investigate how #nutrient availability regulates #ECM composition, mechanical properties and biological activity. biorxiv.org/content/10.110…
Check out the most recent work from @ColinSh21573670 and the Muir Lab!! Super exciting stuff!
Super excited to share our new preprint from @ColinSh21573670 on how the tumor microenvironment causes drug resistance in pancreatic cancer: biorxiv.org/content/10.110…
Congrats! @Sunhee_Jung_ @HosungBae Wonsuk and co-authors. We reported in this @NatMetabolism intriguing effects of dietary inulin on changing small intestinal gut microbial fructose metabolism, leading to protective effects on liver. Thanks, reviewers. nature.com/articles/s4225…
The gloriously atmospheric interior of Powell's Bookstore in Hyde Park, Chicago
New study alert! Coming out today @ImmunityCP, we describe crosstalk between dysfunctional mitochondria and telomere damage in the context of tumor-induced T cell dysfunction. I'll tell you how we did it: cell.com/immunity/fullt… 1/
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