Neural Cell News
@NeuralCell
An online resource for the neuroscience research community. Part of the @STEMCELLTech Science News service.
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Stay current on neural stem cell research, brain development, and disease modeling with Neural Cell News. 🧠 🖱️ Subscribe for free newsletters delivered straight to your inbox: bit.ly/4kkWMEu
Dr. @peter_tass and team recently showed how hyperactivity of indirect pathway striatal projection neurons can induce synaptic connectivity changes consistent with Parkinson’s disease animal models. 💡Learn more here: bit.ly/4p1HRAG
Researchers from @UCDMINDINST showed that l-fucose enhanced excitatory neurotransmission and long-term potentiation through regulation of presynaptic release. 📗 More in @ScienceAdvances: bit.ly/4p8zh3n
Dr. Pedro Souza from the @zimmerneurolab, led this study showing that #microglia modulate Aβ effects on #astrocyte reactivity in the living human brain. 🧠 @ufrgsnoticias 👉 More in @NatureNeuro: go.nature.com/4838saT
Congratulations to @lab_schaefer on their recent @Nature study! 👏 The team showed that the protective function of #microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with plaques. go.nature.com/4p0NVJW
Colleagues at @AllenInstitute, Drs. Velthoven and Zeng, led this study presenting the transcriptomic and spatial organization of telencephalic GABAergic neurons. This enables a unified view of the molecular and anatomical organization of GABAergic neurons.…
Dr. Sarah Kucenas (@DrGlia18) and team revealed an active role for radial astroglia in homeostatic cell clearance and cooperation between #microglia and radial #astroglia during zebrafish optic tectum development. 🐟 bit.ly/4oSFSP1
On November 18 at noon, meet Dr. Carissa Philippi, a UMSL neuroscientist using advanced imaging to better understand the brain dysfunctions underlying psychiatric disorders such as depression and PTSD. #NextGen #PrecisionHealth Join the event for free: bit.ly/4nlXnpP
Researchers led by Dr. Pankaj Desai show that a combination of ribociclib and letrozole is likely to be strongly synergistic against #glioblastoma at concentrations of the drugs that can be achieved in the brain. 🧠 bit.ly/3JD0jAE
Dr. Jeannie Chin and team performed RNA-sequencing on the hippocampal dentate gyrus and identified differentially-expressed regulators of #neurogenesis in the Wnt signaling pathway that regulates many aspects of cell proliferation. 👉 bit.ly/3LiegEE
This @MCT_AACR study investigated whether DNA damage repair pathways induced by cisplatin and temozolomide are dependent on Rho pathway activity and actin cytoskeleton dynamics by generating chemoresistant #glioblastoma sublines. 💡 Discover here: bit.ly/47yLK98
Scientists identified transcriptomic differences at the single-cell level, between astrocytes generated from LMX1A reporter positive or negative cells, as well as non-patterned astrocytes and neurons. 🧫🧠 📖 Full story in @eLife: bit.ly/47fmOop
Adults spend nearly half their waking hours engaged in “self-related” thoughts, including reflecting and daydreaming. On November 18, join a free event to learn what’s happening in the brains of people experiencing disorders like PTSD, depression, or brain injury. #NextGen…
Drs. Mandi Gandelman, Stefan Pulst, and team establish STAU1 as a novel modulator of DNA damage and p53-dependent apoptosis, suggesting that targeting STAU1 could be a promising approach to prevent #neurodegeneration in ALS/FTD. go.nature.com/3LhQB7b
🥼 Dr. José-Manuel Baizabal's team reports that PRDM16 interacts with C-terminal binding protein 1 (CtBP1) and CtBP2 to control the transcriptional programs of cortical #neurogenesis and regulate upper-layer neuron migration. bit.ly/3L32o9u
Researchers alongside Drs. Juan Yuan, Subhamita Maitra, & Johan Holmberg show that high levels of HIF2α in neuroblastoma, leads to drastically reduced MYCN protein levels, cell cycle exit, and noradrenergic cell differentiation. 🧠 🔗 bit.ly/3L1bTpL
Drs. Yi Zeng, Aaron Gitler, and colleagues show that loss of TDP-43 from neuronal nuclei of human brain and disease-causing mutations in TDP-43 are associated with widespread changes in alternative polyadenylation. 🧠 @StanfordMed @NatureNeuro | go.nature.com/473g5Oe
Scientists led by Drs. Christopher Glass & Nicole Coufal reveal mechanisms by which reduced microglial MEF2C could contribute to the development of neurological diseases. 📍Now in @NatImmunol: go.nature.com/3WDPamh
.@ucl researchers, including Drs. @mariasecrier & Pietro Fratta, demonstrate that TDP-43 nuclear depletion induces cryptic alternative polyadenylation, expanding the palette of known consequences of TDP-43. 📍 @NatureNeuro | 🔗 go.nature.com/48H4GVv
Drs. @izu__u, L. Miguel Martins, and team suggest that enhancing nucleotide metabolism could improve DNA repair and serve as an adjunct therapy to delay #AlzheimersDisease progression. 🧠 @MRC_TU go.nature.com/4hqHX2u
Scientists identified a biphasic pattern in blood and hypothalamic glucose dynamics during prolonged fasting, revealing an additional threshold-dependent mechanism for counterregulation. 💡Learn more: bit.ly/3Lhrm4T
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