Nucleosome papers 📚 NucPosDB database
@Nucleosome_Bot
Publications about nucleosomes. Maintained by @TeifLab. Also see @TF_binding_bot, @CTCF_papers, @cfDNA_papers, @generegulation. @[email protected]
Great to see that this preprint used our software NucTools to calculate NRL, and reached conclusions confirming our previous paper, which reported effect of linker histones H1 on cfDNA fragmentation patterns and nucleosome spacing in cancer tissues/cfDNA link.springer.com/article/10.118…
Excited to share our latest preprint by Alexis Yang and Gary Lee, in collab with the @jberchuck lab: biorxiv.org/content/10.110…. We found that transcription of enhancers (a mark of activation) causes distinct fragmentation patterns in #cfDNA.
We have a postdoctoral opening for a researcher with experience in bioinformatics of DNA sequencing and machine learning to work on the development of new methods for cancer diagnostics related to nucleosomes, chromatin and more jobs.ac.uk/job/DMK060/sen…. Apply by 21st April 2025!
Nucleosome condensate and linker DNA alter chromatin folding pathways and rates [Qiu et al, 2024] biorxiv.org/content/10.110… ▶️residue-level coarse-grained models; non-Markovian dynamics ▶️10n bp DNA linker lengths favor zigzag fibrils ▶️10n+5 bp chromatin loses unique conformations
![generegulation's tweet image. Nucleosome condensate and linker DNA alter chromatin folding pathways and rates [Qiu et al, 2024] biorxiv.org/content/10.110…
▶️residue-level coarse-grained models; non-Markovian dynamics
▶️10n bp DNA linker lengths favor zigzag fibrils
▶️10n+5 bp chromatin loses unique conformations](https://pbs.twimg.com/media/GclA9u9WUAA8zBr.jpg)
Chromatin architecture mapping by multiplex proximity tagging [Delamarre et al. 2024] biorxiv.org/content/10.110… ▶️Nucleosome maps in 3D with Proximity Copy Paste (PCP) ▶️Connectivity of nucleosomes in S. cerevisiae ▶️Chromatin is predominantly organized in regular nucleosome arrays
![generegulation's tweet image. Chromatin architecture mapping by multiplex proximity tagging [Delamarre et al. 2024] biorxiv.org/content/10.110…
▶️Nucleosome maps in 3D with Proximity Copy Paste (PCP)
▶️Connectivity of nucleosomes in S. cerevisiae
▶️Chromatin is predominantly organized in regular nucleosome arrays](https://pbs.twimg.com/media/GchK9yDXUAA7fBR.png)
![generegulation's tweet image. Chromatin architecture mapping by multiplex proximity tagging [Delamarre et al. 2024] biorxiv.org/content/10.110…
▶️Nucleosome maps in 3D with Proximity Copy Paste (PCP)
▶️Connectivity of nucleosomes in S. cerevisiae
▶️Chromatin is predominantly organized in regular nucleosome arrays](https://pbs.twimg.com/media/GchM9JpXIAAUemJ.png)
Acute multi-level response to defective de novo chromatin assembly in S-phase (Dreyer et al., 2024) cell.com/molecular-cell…
1/n Looking into history of "fragile nucleosomes". The term was introduced in Xi et al, 2011 genome.cshlp.org/content/21/5/7……. But before that, MNase-sensitive nucleosomes were known as "labile nucleosomes", since 1970s academic.oup.com/nar/article/6/…. This term then continued into the NGS era
Chromatin Buffers Torsional Stress During Transcription biorxiv.org/content/10.110… [Jin Qian, Lucyna Lubkowska, Shuming Zhang, Chuang Tan, Yifeng Hong, Robert Fulbright, James Inman, Taryn Kay, Joshua Jeong, Deanna Gotte, James Berger, Mikhail Kashlev, Michelle Wang]
![generegulation's tweet image. Chromatin Buffers Torsional Stress During Transcription biorxiv.org/content/10.110… [Jin Qian, Lucyna Lubkowska, Shuming Zhang, Chuang Tan, Yifeng Hong, Robert Fulbright, James Inman, Taryn Kay, Joshua Jeong, Deanna Gotte, James Berger, Mikhail Kashlev, Michelle Wang]](https://pbs.twimg.com/media/GaKuUcfXwAApEk-.jpg)
CTCF binding landscape is established by the epigenetic status of the nucleosome, well-positioned relative to CTCF motif orientation biorxiv.org/content/10.110…
Our new CTCF breakthrough ms has been posted today at doi.org/10.1101/2024.0… with the following Graphical Abstract:
⚠️ CTCF binding landscape is established by the epigenetic status of the nucleosome well-positioned relative to CTCF motif orientation BioRxiv Sep 26, Md Tajmul et al with Vladimir B. Teif, Victor Lobanenkov & Elena Pugacheva doi.org/10.1101/2024.0… biorxiv.org/content/10.110…
DNA flexibility regulates transcription factor binding to nucleosomes dlvr.it/TCkpV0
Hurry up! Last day to submit abstract for "Genomics in Ageing and Disease" (Colchester, 16th September). Free Registration! Talks by @Peter_Fraser1, @_parker_aim, @GabriellaFicz, @EnrightAnton, @R_Rahbari, @ozgendeniz_, @jordanatbell, @sj_marzi & Essex PIs gate.essex.ac.uk
Single-nucleosome imaging reveals principles of transient multiscale chromatin unfolding triggered by histone ADP-ribosylation at DNA lesions dlvr.it/TCZn9R
The registration deadline for our FREE conference in Colchester is prolonged until 1st September. The conference itself is on 16th September. Short talk slots available, hurry up!
We are organising a conference "Genomics in Ageing and Disease", 16th September 2024, University of Essex, Colchester. More details soon gate.essex.ac.uk
Impacts of nucleosome positioning elements and pre-assembled chromatin states on expression and retention of transgenes dlvr.it/TCCv4G
FACT-(H3-H4) complex stimulates Pol activity to coordinate DNA synthesis with nucleosome assembly dlvr.it/TBhRty
1/ 🤔 Do #chromatinlooping-mediated promoter-#enhancer interactions drive gene expression? Or is the local enrichment of transcription factors into hubs/#condensates the key factor? Our AC/DC model of gene regulation at bioRxiv doi.org/10.1101/2024.0… provides a new view on this.
We have an opening for a three-year postdoctoral position for a researcher with expertise in machine learning and genome bioinformatics, to work on cancer diagnostics (liquid biopsies). Please apply here: vacancies.essex.ac.uk/tlive_webrecru…
Determining mesoscale chromatin structure parameters from spatially correlated cleavage data using a coarse-grained oligonucleosome model dlvr.it/TBDHZZ
Registration (free!) and abstract submission now open! Please, spread the word. gate.essex.ac.uk
We are organising a conference "Genomics in Ageing and Disease", 16th September 2024, University of Essex, Colchester. More details soon gate.essex.ac.uk
The Genomics at Essex conference is back! We are working on it but you can check the latest news here and in gate.essex.ac.uk #gate2024
United States 趨勢
- 1. #AEWDynamite 17.8K posts
- 2. #Survivor49 3,058 posts
- 3. Donovan Mitchell 3,656 posts
- 4. #CMAawards 4,092 posts
- 5. #AEWCollision 5,585 posts
- 6. #cma2025 N/A
- 7. UConn 7,488 posts
- 8. Nick Allen 1,841 posts
- 9. Dubon 3,038 posts
- 10. Cavs 8,268 posts
- 11. Arizona 32.4K posts
- 12. Aaron Holiday N/A
- 13. Rockets 16.2K posts
- 14. Mobley 4,236 posts
- 15. Derik Queen 1,253 posts
- 16. Marquette 2,113 posts
- 17. FEMA 50K posts
- 18. Sengun 5,815 posts
- 19. Jaden Bradley N/A
- 20. Bristow N/A
Something went wrong.
Something went wrong.