Xiaomeng Gao
@XiaomengGao
PhD student, Dr. Bing Ren Lab, UCSD | MS @ Beijing Institute of Genome, Chinese Academy of Science
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Happy to share our paper on the reprogramming of H3K36me2 in early mouse embryos and its role in gene regulation! Heroic work and really huge efforts by Xukun Lu, Lijuan Wang and Yu Zhang. Many interesting findings for H3K36me2. Check it out! nature.com/articles/s4155…
One of this year's Nobel winners might not know he has won. Fred Ramsdell was among those honored Monday with a 2025 Nobel Prize in Medicine, but he's currently "living his best life" on an "off the grid" hiking foray and it appears no one can contact him…
Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team! nature.com/articles/s4158…
“A dream come true”: A child walks again after breakthrough treatment for a rare genetic disorder—thanks in part to NIH-funded research. Scientists at @nyulangone discovered that a CoQ10 precursor can help brain cells restore energy production, offering new hope for families…
In a Science study last year in mice, researchers introduced CHARM, a compact and versatile epigenetic editor that can be used to silence prion protein throughout the brain. Learn more in this #SciencePerspective: scim.ag/3IBm0jz
Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues biorxiv.org/content/10.110… #biorxiv_genomic
WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (@altos_labs 🤑), why the epigenome changes with age at all is unclear. In @NatureAging today, we suggest a potential driver: somatic mutations.
Thrilled to share Perturb-DBiT — spatial unbiased in vivo perturb-seq with genome-scale CRISPR libraries! Hope you enjoy reading it over the Thanksgiving week 🥰 Kudos to @AlevBaysoy, Xiaolong, Feifei, and Paul. & collaboration with @sidichen, Hongbo Chi. biorxiv.org/content/10.110…
Check out our preprint on Perturb-multi (doi.org/10.1101/2024.1…), a multi-year collaborative effort that enabled multi-modal in vivo genotype-phenotype mapping by pooled genetic perturbations and high-dimensionality phenotype readout by imaging and sequencing.
In collaboration with Reuben Saunders, @JswLab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…
I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in @Nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9
Chromatin interactions profiles are useful, but how can we deconvolute cell-type info from the complex tissues? 🎯 Led by @LeiChangpku , we just released Droplet Hi-C: a faster, cheaper, and high-throughput single-cell Hi-C method using microfluidics: nature.com/articles/s4158…
3D tumor genomics!!!
CODA day! The CODA team at @JohnsHopkins maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here: nature.com/articles/s4158…
Spatial epigenome–transcriptome co-sequencing🤩🤩🤩Beyond excited to see it out today @Nature! Enjoyable collaboration between my lab @YaleBME @YaleSEAS @YaleMed and @GoCasteloBranco of @karolinskainst. The most informative tool for spatial multi-omics!! nature.com/articles/s4158…
Physical folding of the human genome is extraordinarily intricate. Bulk methods such as Micro-C revealed fine DNA structures, but cannot solve single cells. The first new addition to our Dip-C family, scMicro-C, finally brings this power to single cells: biorxiv.org/content/10.110…
How is the embryonic chromatin activated? science.org/doi/10.1126/sc… I am happy to share our findings on how Nr5a2 acts as a pioneer factor during the murine zygotic genome activation @ScienceMagazine #ScienceResearch Together with @WataKobayashi, @SiwatChad & Imre Gáspár.
Tiantan Park is very beautiful！Many people come here to pray their dream come true, because they think the Heaven will hear their sound by standing here, it’s amazing . A happy day in early winter!
Online Now: Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response dlvr.it/Sc6lgW
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