Peter Ly
@PeterLyLab
Genome Integrity Lab | Assistant Professor @CRI_UTSW @UTSWMedCenter. We study how chromosomes segregate, break, and rearrange. @peterlylab.bsky.social
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Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. Congrats, Jiahang Miao!! cell.com/cell-reports/f…
@CRI_UTSW continues pushing the boundaries of science and inspiring the scientific community worldwide! Check out two new publications from the DeBerardinis and @Zhu_Lab labs, published this week in @ScienceMagazine. @UTSWMedCenter @ScienceNews @UTSWScience
Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/sc… (1/9)
Nature research paper: Origins of chromosome instability unveiled by coupled imaging and genomics go.nature.com/4oExnHs
We thank @EviSoutoglou and Ruben van Boxtel for sharing their exciting data with the GIIN community yesterday! Our next webinar is on December 2nd, featuring @PeterLyLab and Alessandra Brambati. Do not miss it! Subscribe here to receive updates: docs.google.com/forms/d/e/1FAI…
6 years ago, Lizz took a leap of faith by moving across the country to join our new/empty lab as a research tech. She then became our 1st grad student, playing a big role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.
Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @PeterLyLab & other Ly Lab mates. Next stop: #postdoc!
Imaging the time course of DNA damage response at a nonrepetitive endogenous locus: Cell Reports Methods cell.com/cell-reports-m…
Wonderful conference organized by @zz_zhaozhang @regenberg_lab @Fusion_Conf. Congrats to @stanleylim93 for the #1 best poster. And PI got awarded for his nosiness on other people’s research. Photo credits to @PeterLyLab
Our Spatial Genome Organisation 2025 attendees! Some fantastic presentations, discussions and collaborations have taken place over the past 2 days, with plenty more to come. Its been a pleasure working with Karim, Irene and Matthias on this meeting, looking forward to what the…
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! science.org/doi/10.1126/sc…
And now… part two of our twin papers on how chromosomes find their place before division! Led by @KrunoVuk at @institutrb, out in @NatureComms! doi.org/10.1038/s41467… doi.org/10.1038/s41467… Missed the thread on the first paper? Catch up here: x.com/Toliclab/statu…
Two back-to-back stories on mitosis led by my incredible postdoc @KrunoVuk at @institutrb, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @NatureComms doi.org/10.1038/s41467… doi.org/10.1038/s41467…
📢 Excited to share that our study has just been published in @NatureComms! We uncover how CRL-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.
Excited to see my PhD work out! Here, we find an unexpected epigenetic mechanism that regulates oncogene amplification to promote tyrosine kinase inhibitor resistance in lung adenocarcinoma. Tweetorial below! ⬇️ nature.com/articles/s4159…
nature.com
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification
Nature Structural & Molecular Biology - Starble, Sun, and colleagues identify an epigenetic priming mechanism that promotes oncogene amplification in acquired resistance to tyrosine kinase...
Please consider submitting an abstract for this exciting meeting early next year. Travel awards and short talks are available! To apply for a Scholar-in-Training Award, Please firstly submit your abstract, and then complete a Scholar-in-Training Award Application.
Submit an abstract by December 4 for the AACR Special Conference on Innovations in Kidney Cancer Research (March 13-16; Philadelphia), chaired by Eric Jonasch, M. Celeste Simon, Samra Turajlic, and Qing Zhang. Learn more: brnw.ch/21wWYHZ #AACRkidney26 @QingZhangLab
We’re honored to welcome Dr. Agnel Sfeir, PaineWebber Chair in Cancer Genetics at MSKCC and UTSW alumna, as our keynote speaker at the 2025 Cancer Biology Research Symposium! #UTSW #CancerBiology #ResearchSymposium
Spotlight: Benamozig and @ShoshaniOfer @weizmanninstitute highlight work from the Gorbsky Lab (hubs.la/Q03PKFc50), which shows how chromosomal instability can rapidly cause #aneuploidy. hubs.la/Q03PKFF80 #StemCells
Two back-to-back stories on mitosis led by my incredible postdoc @KrunoVuk at @institutrb, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @NatureComms doi.org/10.1038/s41467… doi.org/10.1038/s41467…
Join us for the #CellDivision2026 meeting in Okinawa. Abstract Submission Deadline: Nov 3. oist.jp/conference/cel…
We are accepting applications for 2 tenure track faculty positions at UTSW in the Department of Cell Biology! Apply before October 31st!
📢The Department of Cell Biology is hiring! We have two tenure track faculty positions open. See below for more information and how to apply. 🧫🧪🔬 jobs.utsouthwestern.edu/job/22292356/a…
Thrilled to announce the launch of my lab @CRI_UTSW this January! We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
We're growing! Our newest Investigator @Henry_de_belly will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henry-… and 📌apply to research in his lab cri.utsw.edu/careers #relentlessdiscovery
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