Manfredini Lab
@RM_Lab_
Prof. Rossella Manfredini's Lab @ UNIMORE. Myeloproliferative Neoplasms | single-cell | mouse models | immunophenotyping | AIRC Mynerva group
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1/Excited to share our latest study on the effect of chromosome 9p duplication in JAK2-mutated Myeloproliferative Neoplasms - now out in @LeukemiaJnl 🎉 nature.com/articles/s4137… 🧵below:
What a blast! Lots of exciting advances in the CHIP/MPN and in the HSC fields and lots of friends to meet @EHA_Hematology 2025!
If you're in coffee break, get a glimpse of our discoveries at Behind the Paper go.nature.com/4fzaO34 Congrats to all the authors who teamed up in this project! 📄🙋🏻♂️🙋🏻♀️🙋🏻
Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T cell exhaustion in JAK2-mutant myeloproliferative #neoplasms, reports a team at @UNIMORE_univ, including Dr. Chiara Carretta. go.nature.com/4e0AVhH
🔸Una nuova alterazione del DNA, responsabile di una forma neoplasia mieloproliferativa, è stata scoperta da un gruppo di ricercatrici e ricercatori del Centro Interdipartimentale di Cellule Staminali e Medicina Rigenerativa (CIDSTEM) di Unimore. 🔗magazine.unimore.it/site/home/noti…
magazine.unimore.it
Identificati nuovi meccanismi molecolari responsabili delle Neoplasie del sangue
Una nuova alterazione del DNA, responsabile di una forma più severa di neoplasia mieloproliferativa, è stata scoperta da un gruppo di ric...
Blockage of CTLA-4, an immune checkpoint receptor on T cells, appeared to boost the cytotoxic T-cell–mediated immune response against #myelofibrosis cells in human xenografts. 📰 Read more: buff.ly/46CCQ9V @LaraTavernari @RuggieroNorfo @RM_Lab_ @AjHematology
Congrats @LaraTavernari , @RuggieroNorfo , and @SebastianoRontauroli for leading this fantastic study on exhausted cytotoxic T cells rescue in #myelofibrosis xenografts! Out today, read it in @AjHematology 👉 doi.org/10.1002/ajh.27…
Outstanding talk by Dr. Ross Levine (@rosslevinemd ) centering on novel reversible murine models to test Jak2 oncogenic dependencies. Dr. Levine also shared exciting data surrounding a novel Jak2 inhibitor showing significant improvements in disease burden in preclinical models.
Great poster session at #ESHMPN2024. Come see our work about chromosome 9p duplication in JAK2V617F MPN patients 🧬
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