Sijie Wang
@SijieWang5
Los Angeles-West Lafayette-Palo Alto, Boilermaker, Postdoc @ Stanford
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Thanks @DanNomura for highlighting our recent work!
Cool paper from Matt Bogyo’s lab: Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
Busy week for @SijieWang5! His second paper in two days is out describing the use of phage display to identify covalent inhibitors of protein/protein interactions. Great work and collaboration. biorxiv.org/content/10.110…
A great collaboration between Bogyo lab and Genentech. I had a lot of fun learning mRNA display and warhead encoding! Big thanks to all collaborators involved in this project! @ec_woods @JeyunJo @BwTabbyGinger @NikkiPedowitz @TulsiUpadhyay5 @ChemBio_John
After a lot of work by @SijieWang5 to finish the project I started while at Genentech on sabbatical last year, we have finally posted the results to bioRxiv. biorxiv.org/content/10.110…
After a lot of work by @SijieWang5 to finish the project I started while at Genentech on sabbatical last year, we have finally posted the results to bioRxiv. biorxiv.org/content/10.110…
Looking for a new covalent electrophile for serine and cysteine nucleophiles? Check out this great work by @JeyunJo and @TulsiUpadhyay5 developing an oxadiazolone based probe for the S aureus serine hydrolase FphE. biorxiv.org/content/10.110…
A huge congrats to my graduate student Andy Heindel for publishing his work on developing PACCE for global quantification of protein-RNA binding activity in live cells. We thank our collaborators Markus Hafner @NIH_NIAMS & Thurl Harris @uvapharmacology. disq.us/t/4jhbf7b
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
Check out our latest work targeting the malaria proteasome. Another outstanding collaboration with @fidocklab. Congrats to @ChemBio_John and the other authors! pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum
The Plasmodium proteasome is a promising antimalarial drug target due to its essential role in all parasite lifecycle stages. Furthermore, proteasome inhibitors have synergistic effects when combined...
Awesome paper from Jack Taunton’s lab @UCSF on direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes using chemoproteomics! nature.com/articles/s4155…
Check it out! @kellerlauraj’s masterpiece of her thesis work is finally in print. Great work and just in time for her graduation. nature.com/articles/s4158…
Did you register yet to ABPP 2023??? 17-19/7/2023 Please RT! 🧪💥weizmann.ac.il/conferences/AB… #ABPP #Proteomics #Covalent #BestMeetingEver
Congrats to BC and YB on their recent paper on DEL selection of biased GPCR agonists! Big thanks to terrific collaborators Amal and Tao! #DELagonists #CIDselection #JACSau pubs.acs.org/doi/10.1021/ja…
Paper just published. That was fast! Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows - Faucher - Israel Journal of Chemistry - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/ij…
Our latest paper is out at bioRxiv. Great work from @FrancoFaucher and collaboration with Alex Adibekian. biorxiv.org/content/10.110…
Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation
Gene regulation via chemically induced dimerization (CID) is useful for biomedical research. However, the number, type, versatility, and in vivo applications of CID tools remain limited. Here, we...
An effective tool developed by Genentech to evaluate the IVT efficiency of NCAA in peptidic library design and synthesis... Titled as "Evaluating Translational Efficiency of Noncanonical Amino Acids to Inform the Design of Druglike Peptide Libraries"pubs.acs.org/doi/full/10.10…
New Receptor “Decoy” Drug Neutralizes COVID-19 Virus and Its Variants ://ms.spr.ly/6047eW78R
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