Xiaojun Ren Group at UNC Charlotte
@XR_Lab
My lab aims to understand the fundamental principles of genome regulation. We are particularly interested in LLPS and single molecules.
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Happy to see this coming out at JCB!
Rongwei Zhao et al. @lab_zhang @CarnegieMellon show that, in #cancer cells using the alternative lengthening of telomeres (ALT) pathway, #SUMO levels at #telomeres influence the formation of ALT-associated PML bodies. hubs.la/Q03GK3qh0
Excited to have this powerful single-molecule microscopy installed. Exciting discoveries will come soon……
We are pleased to announce the Inaugural 2025 Carolina Symposium on Genome Integrity and Chromatin Regulation on June 11, 2025 @unccharlotte Free registration, abstract for talk/poster: biology.charlotte.edu/announcing-the…
Cryo-EM reveals mechanisms of natural RNA multivalency | Science science.org/doi/10.1126/sc…
Imaging single endogenous RNA in live cells comes true!
Really excited to unveil sandbox.bio, an interactive playground for learning bioinformatics command-line tools like bedtools, bowtie2, and samtools (and more to come!) 🧑💻 🧬 Thanks to @aaronquinlan, @BenLangmead, and @mike_schatz for feedback and tutorial ideas.
My lab is looking for a postdoctoral fellow. Exciting opportunities for LLPS, single-molecule imaging, genomic approaches, and genetic engineering. Pls RT
Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides: Molecular Cell cell.com/molecular-cell…
cell.com
Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides
When ribosomes stall during translation of defective mRNAs, the resulting incomplete polypeptides form detergent-insoluble aggregates. Chang & Yoon et al. demonstrate that threonine residues drive...
As a new faculty member at UNC Charlotte, I am excited to present my first seminar here. @ShanYanLab Thanks for the picture!
Excited to share that our paper cell.com/molecular-cell… got the cover of the new issue of @MolecularCell. Extra cool that this is a photograph taken by the first author @Nancybrillet, a super-star research assistant and post-bacc who just started grad school @UTSWGradSchool
So cool to see @tgwgraham’s work featured in the @Nature Briefing today! Read more about our developments to detect single molecule protein-protein interactions in live cells here : nature.com/articles/d4158…
Registration for the 5th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer is NOW OPEN! Get ready to hear from an all-star lineup of speakers – you won't want to miss this. Register for free: bit.ly/chromatin-2024 #chromatin2024
🚀 My lab is recruiting technicians, PhD students, and postdocs! Join us to leverage single-molecule techniques, genomic approaches, and genetic engineering to explore the roles of LLPS in genome regulation. Exciting opportunities to contribute to cutting-edge research!
🚀 Thrilled to announce my lab has moved to UNC Charlotte, a vibrant and rapidly growing university! Huge thanks to my colleagues, collaborators, and friends for their support over the years. Excited for this new chapter and the great science ahead! 🌟🔬
Proud of grad student @megan_mitchem on her winning image "Guardian of the Cell" in the @ASBMB Molecular Motifs bioart competition! 🔥🔥🔥asbmb.org/asbmb-today/pe… #hsp70 #chaperone @unccharlotte @UNCCBiology
Please RT: We have Senior Scientist, Postdoctoral Researcher and PhD student positions available in our lab focusing on the role of Hsp70 PTMs in a variety of processes including cancer, aging and host-pathogen interactions. Please see: trumanlab.org/contact #hsp70 #chaperones
Demixing is a default process for biological condensates formed via phase separation: science.org/doi/10.1126/sc…
Congratulations Shankar Balasubramanian of @Cambridge_Uni, newly inducted NAS international member! #NAS161 #NASmember #chemistry #biochemistry
Happy to share that our work on how small set of motifs and rules explain most human promoters is published in @ScienceMagazine I am very grateful for the chance to be part of a team of amazing scientists: Donghong Cai, Chenlai Shi,@JianXuLab,@zhou_jian science.org/doi/10.1126/sc…
Online Now: A validation strategy to assess the role of phase separation as a determinant of macromolecular localization dlvr.it/T5QQqF
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