Yajie Zhao, 赵亚杰
@ZhaoDylan
Group Leader of Changping Laboratory & Visiting Scientist at @MRC_Epid & Human Geneticist🧬/ Photographer📷/Cat Enthusiast🐱
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Excited to share our latest publication identifying novel genes associated with the risk of obesity and type 2 diabetes, leveraging whole-genome sequencing data from the @uk_biobank and @AllofUsResearch. nature.com/articles/s4158…
In a paper just published in Nature Medicine, we characterised the largest cohort of people with loss-of-function mutations in the Melanocortin 4 receptor (MC4R) gene. doi.org/10.1038/s41591… (1/6)
'Sir John will be greatly missed by everyone here in Cambridge, but he leaves behind him an outstanding legacy for which we are extremely grateful." — Vice Chancellor, Professor Deborah Prentice We are deeply saddened to hear of the passing of Nobel Laureate and Master of…
Congratulations to Cambridge alumnus Professor John Clarke, who has been jointly awarded The @NobelPrize Prize in Physics – making this Cambridge's 126th Nobel win 🏆 👏 Read about his work and his long connection with Cambridge: cam.ac.uk/research/news/…
We’re excited to share our latest publication in @CellGenomics: “Streamlining Large-Scale Genomic Data Management: Insights from the UK Biobank Whole-Genome Sequencing Data”. Sincerely thanks to @drarwood, @muzizimumu1, @XihongLin, Yuxin Yuan, Gareth Hawkes, Robin Beaumont,…
Streamlining large-scale genomic data management: Insights from the UK Biobank whole-genome sequencing data dlvr.it/TN8k2L
1/7 New article : "Regulatory Genomic Circuitry of Brain Age by IntegrativLe Functional Genomic Analyses". zhao et al. integrate AI, genomics, and systems biology to decode the biology of brain aging OA: academic.oup.com/gpb/advance-ar… 🧠🔬
Most cell type–specific expression (CTSE) estimates from bulk RNA-seq may be no better than just using bulk itself if you want cell type-specific inter-sample expression variation😬. We benchmarked 7 popular methods across 3 tissues biorxiv.org/content/10.110… Here’s what we found 👇
Patterns and drivers of 43,617 mosaic chromosomal alterations in blood medrxiv.org/cgi/content/sh… #medRxiv
Such a impressive work! Congrats @bloodgenes and team!
Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.110… 🧵 below ...
1/ CAPTAIN is coming! We are excited to introduce our new single-cell multimodal foundation model, CAPTAIN. 📄 Preprint: biorxiv.org/content/10.110… 💻 Code: github.com/iamjiboya/CAPT…
Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell. nature.com/articles/s4158…
Great work, congrats @David_J_Adams !
A new drug target that has the potential to treat aggressive eye cancer has been discovered 👁️ This research may provide a hopeful outlook for eye cancer patients with very limited treatment options and has implications for a range of other cancers ⤵️ sanger.ac.uk/news_item/new-…
Our scMicro-C paper is out in @NatureGenet! Huge thanks to the reviewers for their valuable insights, to @XieSunney for unwavering support, and to fantastic collaborators @JiankunZhang21 & @tanlongzhi. Thrilled to share this work!
Very excited to share our work on high-resolution single-cell Micro-C, which is on bioRxiv now. Here we reveal that cohesin-mediated loop extrusion participates in transcription with kilobase-resolution single-cell 3D structures. biorxiv.org/content/10.110…
One year ago, I returned to China to build my own research group from scratch. Today, I’m proud to have such a productive and capable team.
SARS-CoV-2 variants NB.1.8.1 and XFG are spreading fast. In this new paper, we explain their high growth advantage. 1. XFG is strong in immune evasion but shows lower ACE2 binding. 2. NB.1.8.1 is very well-balanced between immune evasion and ACE2 usage. thelancet.com/journals/lanin…
Well deserved! Congrats @StephenORahilly!
Delighted that Professor Sir @StephenORahilly from @IMS_MRL has been announced as joint winner of the Distinguished Service Award at the 2nd Lund Spring Symposium, along with Professor Jens Juul Holst More details 👇 mrl.ims.cam.ac.uk/news/professor…
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