_Biohacking's profile picture. Based in Nagano, JAPAN. Obsessed w/ Rapamycin, Spermidine, mTOR, Autophagy, Fasting, Sulforaphane and the Hyperfunction Theory of Aging.

Charles Nelson

@_Biohacking

Based in Nagano, JAPAN. Obsessed w/ Rapamycin, Spermidine, mTOR, Autophagy, Fasting, Sulforaphane and the Hyperfunction Theory of Aging.

Charles Nelson 님이 재게시함

Product review @whoop coach: “It's a dawning of an era of truly smart wearables – and ironically it's one with no screen that's leading the way.” ⁦@wareablewareable.com/wearable-tech/…


Charles Nelson 님이 재게시함

high protein (good). Low/restricted protein extends lifespan in animals when given at birth, during developmental growth, yearly in life. ALL nutrients activate mTOR. Just combine protein with rapamycin

In light of mTOR activation, what’s your recommendation regarding high/low protein diets?



Charles Nelson 님이 재게시함

Decreasing your glycogen stores is a key to increasing insulin sensitivity, and with aerobic exercise, it may take hours to deplete them. High-intensity exercise can do that in minutes.

Mangan150's tweet image. Decreasing your glycogen stores is a key to increasing insulin sensitivity, and with aerobic exercise, it may take hours to deplete them.  

High-intensity exercise can do that in minutes.

Charles Nelson 님이 재게시함

It's a pernicious myth that you can't be lean and healthy as you get older, say at 68, my age. You don't have to be medication-dependent and declining in health. It doesn't even require much time. But it has to be your priority.

Mangan150's tweet image. It's a pernicious myth that you can't be lean and healthy as you get older, say at 68, my age.

You don't have to be medication-dependent and declining in health.

It doesn't even require much time.

But it has to be your priority.

Charles Nelson 님이 재게시함

A low ratio of triglycerides/HDL means a low risk of heart disease even when LDL ("bad") cholesterol is high A high ratio means higher risk even with low LDL. Triglyceride/HDL ratio is related to insulin resistance, not cholesterol. jamanetwork.com/journals/jamai…

Mangan150's tweet image. A low ratio of triglycerides/HDL means a low risk of heart disease even when LDL ("bad") cholesterol is high

A high ratio means higher risk even with low LDL.

Triglyceride/HDL ratio is related to insulin resistance, not cholesterol.

jamanetwork.com/journals/jamai…

My RECOVERY improved by 3% in the Recovery Impact Analysis on my #WHOOP by taking my 10mg of #Rapamycin a week. Thats not bad! [The Rapamycin is taken instead of the Multivitamin].

_Biohacking's tweet image. My RECOVERY improved by 3% in the Recovery Impact Analysis on my #WHOOP by taking my 10mg of #Rapamycin a week. 

Thats not bad! 

[The Rapamycin is taken instead of the Multivitamin].

100% sleep performance streak, 1st month complete ✅ @bryan_johnson data via @WHOOP

_Biohacking's tweet image. 100% sleep performance streak, 1st month complete ✅
@bryan_johnson 

data via @WHOOP

An “epic podcast” is an understatement! This episode is packed with such brilliant and invaluable information..

In this epic podcast episode I interview the world's leading Rapamycin researcher @Blagosklonny. His contribution to moving the Rapamycin longevity field forward has been huge and we would not be here where we are today without all his great work and passion in the field. I feel…

KristerKauppi's tweet image. In this epic podcast episode I interview the world's leading Rapamycin researcher @Blagosklonny. His contribution to moving the Rapamycin longevity field forward has been huge and we would not be here where we are today without all his great work and passion in the field. I feel…


Charles Nelson 님이 재게시함

A fresh perspective by Dr. João Pedro de Magalhães challenges the conventional wear and tear theory, proposing that the very mechanisms fueling growth could be steering our decline post-reproductive prime gethealthspan.com/blog/articles/…


Charles Nelson 님이 재게시함

Please retweet: If you are taking rapamycin, please complete our Survey #2: rapamycin.news/t/rapamycin-us…


Charles Nelson 님이 재게시함

mTOR activity is dysregulated with age—accelerating immune system dysfunction. @MannickJoan's research explores mTOR's impact on aging immune function. The results are fascinating. While daily mTOR suppresses immunity, low or intermittent doses of inhibitors seem to enhance it

healthspanmed's tweet image. mTOR activity is dysregulated with age—accelerating immune system dysfunction.

@MannickJoan's research explores mTOR's impact on aging immune function.

The results are fascinating.

While daily mTOR suppresses immunity, low or intermittent doses of inhibitors seem to enhance it

Charles Nelson 님이 재게시함

Woke up this morning to a brutal workout, hot sauna, and freezing cold shower. When you start your week kicking your own ass, it becomes a lot harder for anyone else to 👊🏼


I would like to see how @bryan_johnson is doing after a month on his new #Rapamycin protocol. I started taking 10mg/weekly from July as well.

Interesting, Bryan! So if I understand it correctly you will change your dose regime from 13 mg once every other week to taking it every week as above. Which means increased Rapamycin intake from what you have taken before. 1) My guess why you use 6 mg on alternate weeks is…



Charles Nelson 님이 재게시함

10月中旬にアムステルダムで開催される大規模なバイオハッカーサミットへの準備として、ロンドンでウォームアップの1DAYイベントで開催します! @TatekiMatsuda もEUのトップバイオハッカーに混じって登壇予定です。


_Biohacking @WHOOP group created. We might need a Blueprint group as well. @bryan_johnson #blueprint

_Biohacking's tweet image. _Biohacking @WHOOP group created. We might need a Blueprint group as well. @bryan_johnson #blueprint

Charles Nelson 님이 재게시함

I woke up this morning and REALLY didn’t want to get out bed. “Cancel the workout, sleep in.” Whoop said I was recovered, I said “No, I’m tired.” Whoop won. Discipline prevailed.

willahmed's tweet image. I woke up this morning and REALLY didn’t want to get out bed. “Cancel the workout, sleep in.” Whoop said I was recovered, I said “No, I’m tired.”

Whoop won. Discipline prevailed.

Charles Nelson 님이 재게시함

"What @bryan_johnson is seeing in terms of biological age reductions ... can likely entirely be explained by his rapamycin and acarbose use" A great short post by @RapaNews: rapamycin.news/t/is-bryan-joh…


100% sleep performance streak, week 2 complete ✅ @bryan_johnson … I’m coming for you. Data via @WHOOP

_Biohacking's tweet image. 100% sleep performance streak,
week 2 complete ✅

@bryan_johnson … I’m coming for you. 

Data via @WHOOP

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