Nathanael Rollins
@_nathanrollins
learning from evolution + synthesizing biology https://scholar.google.com/citations?user=TveAliEAAAAJ&hl=en&authuser=2&oi=ao
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Zero-shot antibody design in a 24-well plate @chaidiscovery 1. Researchers have introduced Chai-2, a multimodal generative model that marks a significant leap in de novo antibody and miniprotein design. This platform achieves an impressive 16% hit rate in de novo antibody…
It's been a privilege work alongside the most uniquely talented group of individuals I've ever encountered on this breakthrough result @Kevin_E_Wu, @_nathanrollins, @j_boitreaud, @danny_nkjg, @_jackdent , @joshim5, @ZhuoranQ and others. You all made this possible!
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
How can we use #GenerativeAI for #ProteinDesign? - check out work from our labs @deboramarks and @yaringal nature.com/articles/s4158…
Want to catch up with the rapid progress in ML for functional protein design? Not sure where to start? Check out our review in Nature Biotech! #ProteinDesign #NatureBiotechnology #Cover
The February issue, with a focus on protein engineering, is live nature.com/nbt/volumes/42… Our cover shows the three data types key to machine learning for functional protein design: structure, sequence and labels, from a Review by Notin et al. go.nature.com/49EPi9x
New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint elifesciences.org/reviewed-prepr…
New preprint out! Babies are born to breastfeed. While 50% of lactating persons struggle to make enough milk, there are no FDA-approved drugs to enhance lactation. We engineered a long-acting prolactin, Prolactin-XL, to enhance milk production. bit.ly/prolactin-XL 1/14
Announcing popEVE - a deep generative model of the human proteome that reveal over a hundred novel genes involved in rare genetic disorders medrxiv.org/cgi/content/sh… @Jonnygfrazer @aaronkollasch @H__Spinner @c_sheare @MafaldaFigDias @deboramarks explore at pop.evemodel.org
Excited to debut our work: ML methods that accelerate the development of proteins of interest into full-fledged therapeutics. By making proteins safer, faster, we hope to expand the space of therapies in the clinic!
We're looking forward to presenting preclinical data describing the application of our IMPACT platform at PEGS Boston 2023 #PEGS23 next week, the world’s largest gathering of protein engineering and biotherapeutics experts. #WeAreSesimic seismictx.com/seismic-therap…
But if we show all the gene knockouts ordered by genomic position, a curious pattern emerges: CRISPR knockouts look more similar to KOs on the same chrom. arm than to KOs on other arms –producing a striking image of a genome-wide CRISPR map in which genome structure is obvious!
We’ve updated our EVEscape paper with more SARS2 retrospective evaluation and potential use-cases! biorxiv.org/content/10.110… Collaborators @sarahgurev @NotinPascal @nooryoussef03 @_nathanrollins @sandercbio @yaringal (@OATML_Oxford), @deboramarks, 🧵1/4
Can one anticipate viral evolution enough to support timely intervention? Check out our new preprint on forecasting antibody escape biorxiv.org/content/10.110… With @sarahgurev @NotinPascal @nooryoussef03 @_nathanrollins @sandercbio @yaringal (@OATML_Oxford), @deboramarks, 🧵1/10
Our new paper is out in @nchembio where we describe our journey from a #covalent fragment screen to an in vivo active Pin1 inhibitor. nature.com/articles/s4158… Below is a musical abstract guest-starring @UriAlonWeizmann and a tweetorial 1/n
Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 drive.google.com/file/d/1oH4W0z…
1/n I'm excited to share our preprint *Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning* biorxiv.org/content/10.110… from a great collab with @NotinPascal @MafaldaFigDias @AidanNGomez @kpgbrock @yaringal (@OATML_Oxford) @deboramarks 🧵
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