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🧬 Prime Editing, Clinically Validated Prime Medicine just delivered the first-ever human proof-of-concept for its Prime Editing tech. One patient. One infusion. 66% enzyme restoration by Day 30. A legit inflection point for gene editing. Let’s break it down:
BREAKING NEWS NEW 24 month data 🧵 $NTLA now owns the ATTR-PN space. In 2024, $ALNY made $1.223 billion in ATTR-PN. Here is what $NTLA presented for ATTR-PN last November. And it was honestly underwhelming… That definitely changed today.
$ntla 🧬
1/🚨WOW! @intelliatx announced positive two-year follow-up data from its ongoing Phase 1 trial of nex-z / $NTLA-2001 for the treatment of hereditary ATTR amyloidosis with polyneuropathy (ATTRv-PN). Nex-z’s clinical data showed a deep, durable and consistent reductions in serum…
Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new @arcinstitute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab. 1/13 drive.google.com/file/d/1I-UbCR…
Deserves a repost for all genomic investors. Truly remarkable and the scientific progress is humbling! Love this story! $XBI $ARKG $PRME $CRSP $NTLA $BEAM
Remarkable. The best of US science and medicine. $XBI Explore this gift article from The New York Times. You can read it for free without a subscription. nytimes.com/2025/05/15/hea…
Pathetic service and chaos situation at Frankfurt airport. #UK026 #FrankfurtToDelhi #Vistara #Airlines @airvistara #flightCancellation #mismanagement #2ndDec2023
"India has 140 crore people, and if X% can become customers because of Y% in a developed country," is a dangerous line of thinking for founders and investors. While building for up to 3% of English-speaking affluent Indians is easier, it's much harder and complex beyond that.…
Another feat around the corner for India's space glory, Hoping for the best for tomorrow's Moon landing. 🤞🏻🌚 Go India Go! 🇮🇳 🚀🚀🚀 #Chandrayaan_3 #Chandrayaan3 #Chandrayaan3Landing #ISRO #SpaceX #SpaceExploration #Luna25
India's bold quest for lunar exploration continues with Chandrayaan 3! 🚀🤞 On August 23, 2023, the Vikram lander and Pragyan rover will touch down in the Moon's south pole region, opening new horizons for scientific discovery and innovation. 🇮🇳 #Chandrayaan3 #LunarExploration
C02 Where does it come from? Where does it go? NASA's satellite constellations & advanced computer models give us a first deep look at it 😱 🧵 Let's dive in
The Next Frontier For Large Language Models Is Biology “Just as mathematics turned out to be the right description language for physics, biology may turn out to be the perfect type of regime for the application of AI.” - DeepMind CEO #CRISPR #GeneEditing forbes.com/sites/robtoews…
At least 70bn tonnes of ultra-pure phosphate rock, vanadium and titanium have been found in south-western Norway econ.st/3NZXjh0
Be inspired in 15 minutes: @SammyBasso, the world's oldest living progeria patient, explains how he maintains such a positive life philosophy, working with us every week to advance a gene editing treatment towards the clinic. Video: dropbox.com/s/l7gltr1ktaln… @BrilliantMindsSthlm
This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating age-related diseases 14/17
🧬 30 Days of Great Biology Papers. From the origins of the genetic code to pioneering work on circadian rhythms...these are my favorite snapshots from the history of biology. All the papers — and explanations — in a single thread: 🧵
Ranking #CRISPR technologies by utility. This will assume all the tech works as advertise as that is a completely different issue. 1. Prime Editing becuase it has full utility to insert, do knockouts and make corrections without any of the toxic double stranded breaks. $PRME…
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