おすすめツイート
A neat model (scTranslator) trained on samples with both transcriptomic and proteomic data can infer (with good accuracy) protein levels from RNA. This could be very useful, as measuring proteins, especially at a single-cell level, is much harder than measuring RNA.
Most PhD students struggle with academic writing. Their research is solid but writing doesn't reflect expertise. Harvard College Writing Center created a FREE 33-page comprehensive guide. Same writing system that trains future leaders. Zero cost.
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci go.nature.com/49EhzA4
Hematology X biophysics = new leukemia pathogenesis paradigm! Our collaborative work with @RibackLab on NPM1c-mutant leukemia is live @CellCellPress! Multiple oncoproteins form similar nuclear condensates that massively drive leukemia-gene transcription!
(1/10) How do diverse leukemia mutations converge on the same molecular program? In our new study @CellCellPress,the @RibackLab and @Goodell_Lab show that disparate mutations rewire shared protein networks to form nuclear condensates called coordinating bodies (C-bodies).🫧
How does the evolution of the cancer epigenome contribute to immune evasion? We investigated this in colorectal cancer, where we found that immune evasion follows a ‘Big Bang’ evolutionary pattern, initiated right at transformation: nature.com/articles/s4158…
For those fascinated by metabolism and red cells, we review the latest advances in understanding how metabolic regulation shapes erythroid cell development and discuss emerging metabolism-targeted therapies for both rare and common red cell disorders. sciencedirect.com/science/articl…
Enjoyed reading the recent paper from gnomAD team on the modifiers of penetrance of clinically-relevant variants in 800k individuals in the gnomAD database. One example highlighted in the paper is extremely fascinating! It's a beautiful example of a loss of function (LOF)…
Induced proximity-based therapeutic modalities nature.com/articles/s4157… rdcu.be/eOfBH This new Review discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
A bird's eye view of the human genetics of non-alcoholic fatty liver disease (NAFLD) showing genes linked to NAFLD via common and rare germline variants and somatic mutations, from a recent review by Mancina, Valenti & Romeo. Nat Metab 2025 (nature.com/articles/s4225…) One thing…
Great preview from @SanchoShimizu on the challenge of VUS in inborn errors of immunity and in general. AND on the fact that IEIs are likely more common than thought in general pop. cell.com/cell/fulltext/… in @CellPressNews
Curious how proteins find their way to #LipidDroplets? Our bipartite review traces their journey from ER insertion to LD partitioning: 👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning tinyurl.com/377hn9zs
portlandpress.com
Navigating lipid droplet proteins – part II: molecular mechanisms underlying ER-to-lipid droplet...
Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phosphol...
Excited to present at USCAP 2026 in San Antonio! Grateful for the opportunity to present and connect with the incredible pathology community! #hemepath #uscap2026
The functional impact of 17,000 (!) missense LDLR variants on LDLR cell-surface abundance and LDL uptake and their effects on hyperlipidemia phenotypes @ScienceMagazine
In this 6-min video, I show how to use iDEP to interpret bulk RNA-seq data. Start with QC plots and exploratory analyses before identifying differentially regulated genes and pathways. Here, we picked up on high mitochondrial rRNA counts, one male sample mixed in with seven…
Entering our fourth decade: The next chapter of Liver Transplantation by @acv69cardenas @timucin_taner journals.lww.com/lt/citation/99…
We published on the feasibility of panel-based PGx testing from @MayoClinicCIM grant in 2017. ✔️Quick cheek swab/mail-out. 🧪 ✔️3-5 days turnaround.⏱️ ✔️Cost effective. Cheaper to do 29 genes than ordering one gene.🤯 ✔️Oncology➕Supportive care🧬 🔗journals.sagepub.com/doi/10.1177/15…
The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests, which Drs. Laurent Castera, Mary E. Rinella, and Emmanuel A. Tsochatzis review.…
I just got laid off this morning from Myriad Genetics Looking for new opportunities, RT’s appreciated, DM’s open My experience: Protein design + engineering NGS + Bioinformatics + some software dev Data Science + Analytics Synbio + Cancer Genetics
New in @MolecularCell! We discovered how mitochondrial succinate dehydrogenase (SDH) controls purine synthesis—and it's not what you'd expect. SDH loss → succinate buildup → SHMT2 succinylation → blocked one-carbon flow → no purines 🧬
Excited to share our latest work out today in @MolecularCell, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Congratulations to first author @MushtaqNengroo! sciencedirect.com/science/articl…
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