David MacHugh
@david_machugh
Full Professor of Functional Genomics, Animal Genomics Group, University College Dublin.
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Our @CommsBio #bovineTB #eQTL #TWAS #OneHealth paper on #WorldTBDay. Excellent #ComputationalGenomics work by @jf_grady & collaborators @roslininstitute, @ETH_en. Support @agriculture_ie, @Researchirel, @UCD_OneHealth, @UCD_Conway, @ucdagfood, @ucdvetmed nature.com/articles/s4200…
It’s essentially a bargain bin Mary Robinson versus a pound shop Mary McAleese #rtept
Delighted to share our review on the relevance of epigenetics for the diagnosis of bovine TB with @david_machugh and @Eamonn_Broc @ucdagfood @ucdvetmed @UCD_CHAS @UCD_Conway Funding from @Researchirel sciencedirect.com/science/articl…
Our new #FunctionalGenomics study of #trypantolerance in African cattle. Great work @GillianMcHugo & collabs inc. @james_akw @kmeade11, @emmelinehill @Tom_JHall Support: @IrishResearch @ucdagfood @UCD_Research @UCD_OneHealth @GenomicsCRT @UCD_Conway doi.org/10.1371/journa…
⚡️Thrilled that #VirtualLab is published in @Nature! nature.com/articles/s4158… We created a team of AI agents to mirror my Stanford lab🤖. Led by a PI agent, the AI scientists ran their own group meetings and discovered effective binders to new CoVID variants that we validated.…
1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?” RFK Jr: “The truth is, I don’t know.” This is outrageous. I do know. The answer is: unequivocally no. 🧵
Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
Thread: Multi-omics sounds cool—until you actually try it. Here's are the nuances. 1/ You’ve got RNA-seq. Methylation. Proteomics. Time to “integrate” the data. But how? And why? Let’s break it down.
Structural variants are important! However, genotyping them accurately remains a challenge. We've sequenced 120 bulls with HiFi reads to investigate the contribution of structural variants to complex traits. biorxiv.org/content/10.110…
Fantastic work @jf_grady - and thanks to our collaborators @LingzhaoF, @animal_eth, @icgormley, and #SteveGordon
Our new #integrative #genomics work on human #tuberculosis is now available as a preprint! Check it out below 👇 - all feedback welcome. Support from @Researchirel @GenomicsCRT @ucdagfood @UCD_Conway @animal_eth @QGG_AU biorxiv.org/content/10.110…
1/ A study by Dr. Peter Hotez and colleagues estimates that over 200,000 Americans died needlessly during the COVID-19 pandemic—due to vaccine refusal fueled by disinformation. This thread breaks it down.
Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out @NatureGenet. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. nature.com/articles/s4158…
Great to see the Farm Animal Genotype–Tissue Expression (#FarmGTEx) Project perspective article published in @NatureGenet. A fantastic #livestock #FunctionalGenomics project led by @LingzhaoF at @AarhusUni_int. nature.com/articles/s4158…
Gratz to #KevinDaly @ucdagfood, @UCD_CHAS, and @UCD_Conway for this exciting @ScienceMagazine #paleogenomics and #PopulationGenomics study on the origins and dispersal of domestic sheep. This work was led by @brad_dan @tcdgenmicro. doi.org/10.1126/scienc…
I’ve seen my share of anti-science activists. But few are as dangerous as Vandana Shiva. She brands herself as a "food sovereignty" advocate. In reality? She’s an activist spreading misinformation about GMOs, pesticides, and modern agriculture. Here’s the real story 🧵: 1/
🧵1/2 The Guardian columnist who wrote yesterday's op-ed about Trump's executive order reached out to me Friday morning for some "expert commentary." TLDR: I provided her with plenty of scientific evidence/argument/detailed commentary in answer to her questions about Trump's…
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