What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721 doi.org/10.1101/2024.0…
This is a really fun project - we modeled experiments from @KKLabJHU doi.org/10.1126/sciadv… - trying to capture how rates and distributions of cluster size depend on the geometry of the channel they're invading into.
We find cell dissociation depends on cell-cell adhesion, noise in cell motility, the presence of leader cells, as well as some surprises -- like cell-channel adhesion.
For physicists, we also show that there's a big difference between "jammed" and "unjammed" tissues. We find unjamming is necessary - but not sufficient - to predict the ability of cells to dissociate from an invading front.
Much much more in the paper, so I won't drag on here. Congrats to @wwang721 !
United States الاتجاهات
- 1. #SantaChat 4,985 posts
- 2. Jack Smith 59K posts
- 3. Luke Weaver 2,484 posts
- 4. Ewers 10.7K posts
- 5. FINALLY DID IT 598K posts
- 6. The Oscars 27.3K posts
- 7. The JUP 154K posts
- 8. #ScalingNow_NXXT N/A
- 9. Gemini 3 Flash 9,579 posts
- 10. NextNRG Inc 1,245 posts
- 11. Mariah 55.5K posts
- 12. Judon 1,733 posts
- 13. Brad Keller 1,563 posts
- 14. Fani Willis 13.7K posts
- 15. Jimmy Stewart 2,267 posts
- 16. Clay Holmes N/A
- 17. Brian Smith 1,000 posts
- 18. Algorhythm Holdings N/A
- 19. 4 Republicans 3,271 posts
- 20. #jonita 16.8K posts
Something went wrong.
Something went wrong.