What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721 doi.org/10.1101/2024.0…
This is a really fun project - we modeled experiments from @KKLabJHU doi.org/10.1126/sciadv… - trying to capture how rates and distributions of cluster size depend on the geometry of the channel they're invading into.
We find cell dissociation depends on cell-cell adhesion, noise in cell motility, the presence of leader cells, as well as some surprises -- like cell-channel adhesion.
For physicists, we also show that there's a big difference between "jammed" and "unjammed" tissues. We find unjamming is necessary - but not sufficient - to predict the ability of cells to dissociate from an invading front.
Much much more in the paper, so I won't drag on here. Congrats to @wwang721 !
United States Xu hướng
- 1. Knicks 78.5K posts
- 2. Mariah 29.5K posts
- 3. NBA Cup 62.8K posts
- 4. Spurs 49.2K posts
- 5. Clarkson 8,726 posts
- 6. Tyler Kolek 7,406 posts
- 7. #NewYorkForever 4,789 posts
- 8. Wemby 27.4K posts
- 9. Brunson 24.4K posts
- 10. Josh Hart 5,999 posts
- 11. Thug 23.4K posts
- 12. Buck Rogers 2,884 posts
- 13. #LMD7 52.8K posts
- 14. Mitch 16K posts
- 15. Gil Gerard 2,838 posts
- 16. Thea 13.9K posts
- 17. Mike Brown 4,897 posts
- 18. Thibs 1,061 posts
- 19. #MAGMA 1,282 posts
- 20. Macklin Celebrini 2,089 posts
Something went wrong.
Something went wrong.