Guy Rutter1
@guy_rutter
Professor of Medicine Université de Montréal, Imperial College London, Nanyang Technological University Singapore. Wellcome Investigator.
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#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring pancreatic beta-cell subgroups and their connectivity nature.com/articles/s4225…
Relaunching our @CRCHUM Cardiometabolic Axis data sessions data sessions today with amazing talks from #mathiasguayasamin and #luisdelgadillosilva. #ciaranmurphyroyal @CRCHUM_CELLS
Not one, but TWO endocrinologists to join the Canadian Medical Hall of Fame in 2026. Both Drs Hegele and Zinman have changed the way we treat metabolic disorders forever. In addition though … they are just kind humans. Congratulations!!🎉🎊🎈
Join us in congratulating the #2026CMHFInductees!cdnmedhall.ca/induction PAVEL HAMET, MD PhD ROBERT ALEXANDER HEGELE, MD MICHAEL D. HILL, MD MARY R. L'ABBÉ, PhD MORAG PARK, PhD BERNARD ZINMAN, MDCM @kellygrant1 @Megan_Ogilvie @LaurenPelley @DubinskiKa4985 @JenLeeCBC @Avis_Favaro
Important new review from my @CRCHUM colleague #MarcDonath
Inflammation is a key driver of the pathophysiology of cardiometabolic disorders #obesity #T2D and new metabolic medicines based on GLP-1 action exert their magic in part by reducing inflammation. A new review from Professor Donath summarizes the field sciencedirect.com/science/articl…
I‑BET151 modulates glucokinase gene expression and beta cellfunction in part through changes in FOXO1 expression rdcu.be/eIBCo Assoc. Prof Yusuf Ali's team @NTU_LKCMedicine in collaboration with @guy_rutter and @astar_research discovered that BET protein inhibition…
All true. But the same rigour should be applied to ALL the antibodies we use. Those against glucokinase are a case in point.
In some of these papers, glp1r detection is a small element. In others it's a large element. Don't trust antibody vendors, and do the legwork. As a field we are always happy to provide reagents/models to help with validation.
Our new report with #YaChiHuang #MarjanRupnik using high-speed imaging in pancreatic slices. Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells | bioRxiv biorxiv.org/content/10.110…
#Throwback REVIEW | @guy_rutter , @BennyScience et al Exploring #pancreatic #BetaCell subgroups and their connectivity nature.com/articles/s4225…
Our new kid on the block to rival or beat existing dual agonists? Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001 - PubMed. pubmed.ncbi.nlm.nih.gov/40831316/
The influence of metformin treatment on the circulating proteome - PubMed. Important new study led by @LeentHart and the EU-funded IMI -Rhapsody and IMI-DIRECT consortia pubmed.ncbi.nlm.nih.gov/40684475/
Thanks again @SoleimanpourLab for the opportunity to be involved and to #MarieGasser for her vital input! Also grateful to the ever-resourceful @carapetop for her help!
P.S. we would be remiss if we did not also thank the amazing reviewers and editor who made our work better and more complete. As well as @cevansmo for the lovely commentary on our work! nature.com/articles/s4225…
Hard to disagree! Looking forward to it!
The best small islet biology symposium in China and Asia, maybe in the world as well:)
Nice one @daveyboyhod !
Dr. David Hodson (@daveyboyhod) and team show that GLP1R is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression. 💡 Learn more: bit.ly/451mubz
Pleased to share that I start a new role today as Head of the Cardiometabolic Axis at the CRCHUM in Montreal. Looking forward to the challenge! chumontreal.qc.ca/actualites/guy…
Semaglutide in Adults with Type 1 #diabetes and #Obesity NEJM Evidence evidence.nejm.org/doi/abs/10.105…
A huge step forward for cell replacement therapy for #T1D @NEJM Vertex clinical trials for zimislecel nejm.org/doi/full/10.10…
Delighted to be elected a Fellow of the Academy of Medical Sciences today. Looking forward to playing an active role in the Academy’s activities in the U.K and abroad. @ImperialMDR @CRCHUM @RIMUHC1 @NTUsg
Congratulations to the 54 exceptional scientists who have been elected to the Academy Fellowship today in recognition of their remarkable contributions to biomedical and health sciences 🎉 Discover more: ow.ly/7u2550VWSRc #AcademyFellows
"If you're working non-stop all the time you will burn out." How do you keep a healthy work-life balance as a scientist? Hear 2009 chemistry laureate Venki Ramakrishnan share his best advice on how to achieve a good work-life balance. #NobelPrize
Standing shoulder-to-shoulder with my #WashU colleagues #StandUpForScience fighting for our work and our future #standupforscience2025
Collaborators including @LioraKatz1, @DKSNYCMSSM, and @COttmann1433 developed highly potent, selective, active stabilizers of the ChREBPα/14-3-3 PPI with a phosphonate chemotype that display activity in both INS-1 cell lines and primary human islets. 🔗 go.nature.com/4i3zoKp
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