
Martin Picard
@MitoPsychoBio
Mitochondrial Psychobiology. Bridging the science of energy and the human experience to create Healing Science. Upcoming book: ENERGY (2027).
قد يعجبك
The Energy Resistance Principle (ERP) is probably the most important paper and theory we've published. authors.elsevier.com/a/1luVK5WXUlaY… The ERP bridges physics and biology, providing a first-principles understanding of the central force behind health and disease dynamics. Delightful to…

He/she who has a why to live can bear almost any how—Nietzsche People reporting greater purpose in life have mitochondria optimized for energy transformation in their brain pnas.org/doi/10.1073/pn…
The most underrated antidepressant: purpose in life
There are too many real life examples showing that textbook central dogma biology doesn’t explain the actual life course of living creatures. What are we missing?
Correcting the epigenome will correct the transcriptome. Correcting the transcriptome will correct the proteome. Correcting the proteome will correct aging. And when we correct aging, we will extend life; and by extending life, we will be free. That's all.

To keep a healthy, social mitochondria collective, the old defective mitochondria need to be removed. The mitochondria life cycle in action. science.org/doi/10.1126/sc…
Good reminder. The might human body does just fine, better in many cases, without carbohydrates and sugars.
I’m not sure who has to hear this but… YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES YOU DO NOT NEED CARBOHYDRATES
As long as you breathe, your energy flows. And as long as your energy flows, you—dynamic energetic process—are transforming and changing.
At 100 your brain can grow new neurons. At 50 your brain can rewire itself. As you read this your brain is changing. “Too old to change” is the biggest lie you've told yourself.

Anytime energy is transformed, the potential for consciousness emerges
I think we should seriously consider this. Sentience/consciousness/self-awareness/experience, whatever you want to call it, likely doesn't have a hard threshold, it's a gradual scale. Even current AIs are bound to have some, if not much. x.com/vitrupo/status…
"The flow of energy through a system acts to organize that system" @stewartbrand had us on the scent many moons ago
How does energy keep us alive? Our bodies are resistive energetic circuits where electrons flow from food→oxygen in our mitochondria. It's only through energy resistance (éR) - like electrical resistance - that transformation of energy into life is possible. The Energy…

The mitochondria of fibroblasts from people experiencing psychosis exhibit different subcellular distribution. Another piece of evidence that the biology of mitochondria is linked to human experiences. Some thoughts on the mind-mitochondria connection here:…
15 years in the making, we confirmed that mitochondria -the powerhouse of the cell- have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery...🧵

Impressive synthesis and integration of concepts around the Energy Resistance Principle @msahsorin
bsahely.com/2025/10/10/the… The Energy Resistance Principle: How Life Balances Power, Flow, and Meaning | ChatGPT5 & NotebookLM Every system that endures — cellular, social, or planetary — must balance the energy it generates with the capacity it has to channel that energy without…

Welcome to the Mitoverse 😀 Great introductory piece on mitochondria from @mitoworld_org stemmagazine.com/gOCT25/viewer/…

« The Energy Resistance Principle stands as a bridge between classical biochemistry and the physics of sentience. It grounds the abstract mathematics of Friston's free energy principle in tangible bioelectrical reality, yet it also opens a door to something larger: a universe…
The theories match because they both touch on something deeply true
I don’t know if he chose the candle analogy above knowing this, but anyone familiar with internal alchemy - transformation - will have seen this candle metaphor a million times. It’s so cool that now it’s showing up in scientific papers 😅.

Upcoming Space on the Energy Resistance Principle @msahsorin and I would love to hear your questions, thoughts, and see what emerges from this dialogue across the physics of energy and the biology of health Set a reminder with this link:

Absolutely gorgeous! This is the kind of biological beauty responsible for setting the energy resistance (éR) level in your mitochondria, enabling the transformation of food into the energy that powers your energetic self. ERP: authors.elsevier.com/a/1luVK5WXUlaY…
The energy resistance principle...big-picture thinking by @MitoPsychoBio and @msahsorin about health, as optimized energy resistance: sciencedirect.com/science/articl…

More and more, we hear about mitochondria in different contexts in relation to health and disease. There are many reasons why that is. I particularly enjoyed this conversation on mitochondria with Big Picture Science. Thank you for examining the facts! bigpicturescience.org/episodes/skept…

Profound insight: "sleep is not something you do." Sleep is not about doing anything, it's about being. Sleep may fundamentally be about letting energy resistance (éR) drop, allowing for growth, maintenance, and repair processes to take over. Unleashing the healing process.
The enemy of sleep is effort Nobody ever fell asleep faster by trying harder So if you wake up in the middle of the night and can't fall back asleep, don't force it... get up Think about it this way: Sleep is not that something you do It's something that happens when the…
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