jonathanloree's profile picture. GI Medical Oncologist at BC Cancer, Associate Professor at The University of British Columbia, Senior Investigator at the Canadian Cancer Trials Group (CCTG)

Jonathan Loree

@jonathanloree

GI Medical Oncologist at BC Cancer, Associate Professor at The University of British Columbia, Senior Investigator at the Canadian Cancer Trials Group (CCTG)

Jonathan Loree reposted

The "Big Bang" of cancer evolution: for colon cancer, evidence that immune evasion occurs very early nature.com/articles/s4158…


Jonathan Loree reposted

So Dill started this to help Canadian patients... and once he got the platform running for Canada... he made it global. In a weekend. Oh, Canada! @ccranorg @coloncanada @CAMO_ACOM @CDNCancerTrials @uoftmedicine @Sunnybrook @BCCancer @GillSharlene @jonathanloree @ocall0

fireflyann's tweet image. So Dill started this to help Canadian patients... 
and once he got the platform running for Canada...
he made it global.   In a weekend.

Oh, Canada!
@ccranorg @coloncanada 
@CAMO_ACOM @CDNCancerTrials @uoftmedicine @Sunnybrook @BCCancer 
@GillSharlene @jonathanloree @ocall0

Results from DYNAMIC-III RCT of ctDNA-guided adjuvant tx in stage III colon cancer in Nature Med. 🙏 to pts, providers & @JeanneTie 🇨🇦🇦🇺 @CDNCancerTrials & @GICancer Collab #ESMO2025 Presidential | Supported by @CIHR_IRSC & @cancersociety in 🇨🇦 🔗 rdcu.be/eLTj8


Jonathan Loree reposted

Excited to be at the #ESMO25 launch of the phase 3 @CDNCancerTrials 🇨🇦 #BATTMAN CO.33 BOT/BAL vs BSC in refractory MSS mCRC #unmetneed #trialsthatmatter Congrats to @jonathanloree 🙌 @ocall0 @Agenus_Bio @GICancer @JeanneTie Let’s get this done! 🇨🇦 🇦🇺 🇫🇷 @coloncanada

GillSharlene's tweet image. Excited to be at the #ESMO25 launch of the phase 3 @CDNCancerTrials 🇨🇦 #BATTMAN CO.33  
BOT/BAL vs BSC in refractory MSS mCRC #unmetneed #trialsthatmatter
Congrats to @jonathanloree 🙌 
@ocall0 @Agenus_Bio 
@GICancer @JeanneTie 
Let’s get this done! 🇨🇦 🇦🇺 🇫🇷 
@coloncanada…
GillSharlene's tweet image. Excited to be at the #ESMO25 launch of the phase 3 @CDNCancerTrials 🇨🇦 #BATTMAN CO.33  
BOT/BAL vs BSC in refractory MSS mCRC #unmetneed #trialsthatmatter
Congrats to @jonathanloree 🙌 
@ocall0 @Agenus_Bio 
@GICancer @JeanneTie 
Let’s get this done! 🇨🇦 🇦🇺 🇫🇷 
@coloncanada…

Jonathan Loree reposted

Dr Booth presenting the #CCTG #CO21 #CHALLENGE trial to the GI tumours group at #ESMO2025 - the study was recently published in #NEJM nejm.org/doi/10.1056/NE…

CDNCancerTrials's tweet image. Dr Booth presenting the #CCTG #CO21 #CHALLENGE trial to the GI tumours group at #ESMO2025 - the study was recently published in #NEJM nejm.org/doi/10.1056/NE…

Jonathan Loree reposted

#ESMO25 @CDNCancerTrials GI disease site is in the house! 🙌 Looking forward to the 🌟 Presidential session later today for DYNAMIC III/CCTG CO.29 🎤 🇨🇦 🇦🇺 📌 ctDNA guided ACT de-escalation in stage3 CC @JeanneTie @jonathanloree @OncoAlert @GICancer #ESMOAmbassadors

GillSharlene's tweet image. #ESMO25
@CDNCancerTrials 
GI disease site is in the house!  🙌 
Looking forward to the 🌟 Presidential session later today for DYNAMIC III/CCTG CO.29 🎤 🇨🇦 🇦🇺 
📌 ctDNA guided ACT de-escalation in stage3 CC @JeanneTie @jonathanloree 
@OncoAlert 
@GICancer 
#ESMOAmbassadors

Impact of Human Epidermal Growth Factor Receptor 2 in Patients With Metastatic Colorectal Cancer Treated With Chemotherapy Plus Bevacizumab or Anti-EGFRs: Exploratory Analysis of Eight Randomized Trials | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…


Jonathan Loree reposted

Exciting science and clinical efficacy in this @MDAndersonNews team science study led by @VanMorrisMD In Cancer Cell. Triple therapy with IO led to durable responses in BRAF V600E MSS colorectal cancer, showing promise. Randomized study ongoing. #crcsm cell.com/cancer-cell/fu…

skopetz's tweet image. Exciting science and clinical efficacy in this @MDAndersonNews team science study led by @VanMorrisMD In Cancer Cell. 
Triple therapy with IO led to durable responses in BRAF V600E MSS colorectal cancer, showing promise. Randomized study ongoing. #crcsm
cell.com/cancer-cell/fu…

Jonathan Loree reposted

Liquid biopsies in #CRC 🩸 Serial MRD monitoring: ✔️Detects recurrence 8–11 months earlier than imaging ✔️Improves sensitivity from 40–50% to 80–90% ✔️Helps monitor ACT response Liquid tumor-agnostic assays are evolving: now integrating ✅Methylation ✅Fragmentomics…

jsoriamd's tweet image. Liquid biopsies in #CRC
🩸 Serial MRD monitoring:
 ✔️Detects recurrence 8–11 months earlier than imaging
 ✔️Improves sensitivity from 40–50% to 80–90%
 ✔️Helps monitor ACT response
Liquid tumor-agnostic assays are evolving: now integrating
 ✅Methylation
 ✅Fragmentomics…

Jonathan Loree reposted

What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72…

SuyogCancer's tweet image. What if this was  a drug  ?🙂 

🆕 NEJM | June 2025
🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer
📦 RCT | n=889 | Median FU: 7.9 yrs
🟠 3-yr structured aerobic program vs health ed alone
📈 Primary Endpoint: Disease-Free Survival (DFS)
🔹 HR 0.72…
SuyogCancer's tweet image. What if this was  a drug  ?🙂 

🆕 NEJM | June 2025
🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer
📦 RCT | n=889 | Median FU: 7.9 yrs
🟠 3-yr structured aerobic program vs health ed alone
📈 Primary Endpoint: Disease-Free Survival (DFS)
🔹 HR 0.72…

Jonathan Loree reposted

Both hand cooling and compression were effective in preventing sensory chemotherapy-induced peripheral neuropathy during taxane-based chemotherapy. ja.ma/4ih0UDi @mbreckwoldt


Jonathan Loree reposted

Cell-free DNA (cfDNA) testing could improve colorectal cancer detection and reduce mortality in Canada, but it requires higher participation rates to be effective compared to current screening methods. ja.ma/4lUmTD1 @jonathanloree


Jonathan Loree reposted

12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak

davidasinclair's tweet image. 12 lessons students learn in the Sinclair Lab:
 
Lesson 1. Write the way you speak

Jonathan Loree reposted

New research: Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for #oesophagealcancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial thelancet.com/journals/lanon…

TheLancetOncol's tweet image. New research: Neoadjuvant chemoradiotherapy followed by active surveillance versus standard surgery for #oesophagealcancer (SANO trial): a multicentre, stepped-wedge, cluster-randomised, non-inferiority, phase 3 trial

thelancet.com/journals/lanon…

Jonathan Loree reposted

Just published in @JCO_ASCO the updated @ASCO guidelines on fertility preservation in people with #cancer: a must read for all colleagues involved in cancer care to increase awareness on #oncofertility issues @OncoAlert @AnnPartridgeMD @oncofertility Link: ascopubs.org/doi/10.1200/JC…

matteolambe's tweet image. Just published in @JCO_ASCO the updated @ASCO guidelines on fertility preservation in people with #cancer: a must read for all colleagues involved in cancer care to increase awareness on #oncofertility issues
@OncoAlert @AnnPartridgeMD @oncofertility
Link:
ascopubs.org/doi/10.1200/JC…

Jonathan Loree reposted

#GI25 ❤️ @ASCO So proud to see our past and present #oncology trainees thriving & making their mark! @jaypsv @jonathanloree @yeung_cynthia @howiel2013 🇨🇦 @BCCancer @UBCmedicine

GillSharlene's tweet image. #GI25 ❤️ @ASCO 
So proud to see our past and present #oncology trainees thriving & making their mark! 
@jaypsv @jonathanloree @yeung_cynthia @howiel2013 🇨🇦 @BCCancer @UBCmedicine
GillSharlene's tweet image. #GI25 ❤️ @ASCO 
So proud to see our past and present #oncology trainees thriving & making their mark! 
@jaypsv @jonathanloree @yeung_cynthia @howiel2013 🇨🇦 @BCCancer @UBCmedicine
GillSharlene's tweet image. #GI25 ❤️ @ASCO 
So proud to see our past and present #oncology trainees thriving & making their mark! 
@jaypsv @jonathanloree @yeung_cynthia @howiel2013 🇨🇦 @BCCancer @UBCmedicine
GillSharlene's tweet image. #GI25 ❤️ @ASCO 
So proud to see our past and present #oncology trainees thriving & making their mark! 
@jaypsv @jonathanloree @yeung_cynthia @howiel2013 🇨🇦 @BCCancer @UBCmedicine

Jonathan Loree reposted

@NCICTEP_ClinRes @SWOG @CDNCancerTrials #Coloncancer Task Force Chairs @smitha42 @jonathanloree hard at work at Oral Presentation session @ASCO #ASCOGI25 analyzing the LBA’s including BREAKWATER, CALGB80702, BESPOKE and CM 8HW. 👏 👏 💪💙

CathyEngMD's tweet image. @NCICTEP_ClinRes @SWOG @CDNCancerTrials #Coloncancer Task Force Chairs @smitha42 @jonathanloree hard at work at Oral Presentation session 
@ASCO #ASCOGI25 analyzing the LBA’s including BREAKWATER, CALGB80702, BESPOKE and CM 8HW. 👏 👏 💪💙

Jonathan Loree reposted

🔥off the press: The use of immunotherapy pre-liver transplant @JHepatology authors.elsevier.com/c/1kNgCcOnAUhMK 👉Hepatology Snapshot 👉Our thoughts on the use of ICI before liver transplant in HCC 👉Food for thoughts.. @myESMO @EASLedu @ILCAnews #livertwitter

ArndtVogel's tweet image. 🔥off the press:
The use of immunotherapy pre-liver transplant
@JHepatology 
authors.elsevier.com/c/1kNgCcOnAUhMK
👉Hepatology Snapshot
👉Our thoughts on the use of ICI before liver transplant in HCC
👉Food for thoughts..
@myESMO @EASLedu @ILCAnews #livertwitter

Jonathan Loree reposted

Recently published: #ClonalHematopoiesis of Indeterminate Potential (CHIP) & Its Association with Treatment Outcomes & Adverse Events in Patients with Solid Tumours. doi.org/10.1158/2767-9… @jonathanloree @jaypsv @rob_vanner @PancreasBC @BCCancer #openaccess

CRC_AACR's tweet image. Recently published:
#ClonalHematopoiesis of Indeterminate Potential (CHIP) & Its Association with Treatment Outcomes & Adverse Events in Patients with Solid Tumours. doi.org/10.1158/2767-9…
@jonathanloree @jaypsv @rob_vanner @PancreasBC @BCCancer #openaccess

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