The Longevity Research Institute
@lifespanscience
Searching for drugs that extend healthy life.
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Fauna Bio’s new blog post by CEO @ashleyz413 is out! Her interview with Prof Jane Khudyakov dives deep into the biology of elephant seals and metabolic syndrome. faunabio.com/new-blog
Old paper: splenectomy in aged mice extends lifespan and injection of spleen cells from old mice shortens lifespan. sci-hub.tw/https://doi.or…
Screening for drugs that restore youthful transcriptomic patterns in vitro yields significant enrichment for known geroprotectors and two Hsp90 inhibitor drugs that extend worm lifespan.
Congrats to Repair Biotechnologies!
Great news for Repair Biotechnologies a new startup company developing solutions to age-related immune system decline and heart disease. leafscience.org/repair-biotech…
30% life extension in males, 40% in females (!) in transgenic mice overexpressing FGF21. As big an effect on lifespan as hypopituitary Snell mice. Also improved insulin sensitivity and reduced adiposity.
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice likely by attending IGF-1 signalling. ncbi.nlm.nih.gov/pmc/articles/P…
foresight.org/event/biotech-… We'll be there!
“Just because a target is genetically validated, it doesn’t necessarily mean to say it’s very druggable.” Nav1.7 is a reminder that human genetic validation represents only the start of a very long drug discovery journey. nature.com/articles/d4157…
journals.plos.org/ploscompbiol/a… Drug-protein interactome analysis predicts many known life-extending compounds plus a new one, an HSP-90 inhibitor called tanespimycin, which extends life in C. elegans.
Introducing our sister organization, Daphnia Labs, a new startup focused on drug discovery for aging. daphnia-labs.com
sci-hub.tw/10.1038/s41586… CD22 prevents microglia from clearing debris in the aging brain -- and CD22 antibody blockade restores microglial homeostasis. Also, aged CD22-/- mice have better memory performance than wild-type, and anti-CD22 infusion mimics this improvement.
leafscience.org/an-interview-w… In vivo cell reprogramming using Yamanaka factors is risky and a long way off. Ex vivo reprogramming might be a more tractable intermediate step. Rejuvenate cells from bone marrow or hypothalamus or muscle and reintroduce them.
singularityhub.com/2019/03/19/fla… Flashing lights seem to reduce amyloid plaques in mice.
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