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The paper is out! If you ever need to analyze any un-targeted #metabolomics data check it out and feel free to DM me any questions! #microbiome #rstats #Bioinformatics mra.asm.org/content/8/15/e…
Salmonella triggers amino acid malabsorption in the ileum to create a a wave of lysine entering the cecum. Decarboxylation of lysine buffers the cytosol to protect against short-chain fatty acids, enabling the pathogen to invade the cecal ecosystem. pnas.org/doi/10.1073/pn…
Excited to share our latest work led by @JoshuaSotoOc & @elliotsfriedman in @mbiojournal today! Together with Gary Wu's team, we suggest metals may be an important nutritional factor shaping early life microbial ecology. journals.asm.org/doi/10.1128/mb…
Excited that our manuscript "CCL28 modulates neutrophil responses during infection with mucosal pathogens" is out in @eLife: doi.org/10.7554/eLife.…; led by the super talented @GregWalker101 and @AraceliPerezLo, with the help of many collaborators (incl. @victornizet and team)
I’m proud to share our recent publication describing the development of a multivalent mRNA-LNP vaccine for C. difficile that incorporates targets across C. diff’s complex life cycle science.org/doi/10.1126/sc…
Delighted to share our work developing an mRNA vaccine for C. difficile, published today in @ScienceMagazine. This study with @WeissmanLab was co-led by two truly amazing scientists: @_alexafluor from the Zackular lab and @MgAlameh (now at @CHOP_Research)! science.org/doi/10.1126/sc…
Excited to announce the launch of the Center for Microbial Medicine @CHOP_Research! This new translational Center of Emphasis at CHOP will be dedicated to finding cures and improving pediatric health through the lens of the microbiome research.chop.edu/cornerstone-bl…
Salmonella breaks colonization resistance Salmonella overcomes colonization resistance w/intact microbiota by disrupting epithelial hypoxia. Outgrowth fueled by catabolizing simple sugars via combo of aerobic respiration & mixed acid fermentation @abaumler cell.com/cell-host-micr…
Salmonella overcomes colonization resistance when the microbiota is compositionally intact by disrupting epithelial hypoxia, which fuels outgrowth by catabolizing simple sugars via aerobic respiration and mixed acid fermentation @cellhostmicrobe @abaumler cell.com/cell-host-micr…
Are you at #ASMicrobe and interested in host-microbiota interactions? Don’t miss this awesome session tomorrow morning with talks from @Wenhan_Zhu1 , @lizljohnson and selected abstracts. 😊
Hypoxia limits C. albicans. Anaerobiosis limits growth of C. albicans. #Antibiotic disruption of anaerobiosis drives C. albicans bloom, which can be prevented w/probiotic bacteria that respire oxygen or pharmacological restoration of anaerobiosis @abaumler cell.com/cell-host-micr…
I still refuse to use Pseudomonadota and Bacillota 😂. Enterobacteriaceae and Clostridia, my two favorites, get no love from the taxonomists.
NCBI is making improvements to our Taxonomy resource in response to new data and changes in biological nomenclature and classification. We will update the higher-level classification of birds, budding yeasts, prokaryotes, and viruses. Learn more: ow.ly/22fZ50S8C6P
An anti-inflammatory curbs spread of fungi causing serious blood infections scienmag.com/an-anti-inflam…
scienmag.com
An anti-inflammatory curbs spread of fungi causing serious blood infections
A team of UC Davis Health researchers discovered that a common anti-inflammatory drug, mesalamine, can replace the work of good bacteria in fighting the nasty fungus Candida albicans in the gut. A...
We found that anaerobiosis limits growth of Candida in the healthy gut, but disruption of anaerobiosis by antibiotics drives an intestinal bloom. Pharmacological restoration of anaerobiosis using drugs that stimulate epithelial oxygen consumption prevents this bloom.
Check out our new paper on how Epithelial Hypoxia maintains colonization resistance against the fungal pathogens Candida albicans. Details on our new metabolomics web app, omuShiny, are also there!
Congratulations to Hannah, Derek and @microbe_enjoyer for our first venture into Candida pathogenesis nam12.safelinks.protection.outlook.com/?url=https%3A%…
This is such a cool story on host-pathogen-microbiome interactions. Congrats to all authors involved!
Very excited to share our new story showing how Salmonella Typhimurium leverages host 🔥 to gain access to microbiota-derived amino acids and outcompete commensal E. coli during colitis. Great effort from co-first authors @WoongjaeY and @ShealyNic ! cell.com/cell-host-micr…
#probiotics: Uncovering the mechanisms of sorbitol intolerance, with Dr. Jee-Yon Lee MD PhD isappscience.org/?p=7393
Excited to share our new review written by the amazing duo grad student @ShealyNic and undergrad Madi Baltagulov discussing the role of the small intestine microbiota in intestinal diseases. onlinelibrary.wiley.com/doi/10.1111/mm…
Congratulations Andreas Bäumler of @ucdavis, newly inducted #NASmember! #NAS161 #microbiology #immunology
Lactate production is important to regenerate NAD+ during anaerobic growth like fermentation (like the microenvironment of a plaque or cavity). How well will it compete with microbes that do not have this fitness disadvantage? Seems like they aren't considering ecology here.
landing page also seems medical claimy to me, but honestly glad someone is trying to productise this
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