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Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method by Miyachi, R., Masuda, K., Shimizu, Y., Ichihashi, N. nature.com/articles/s4146…
Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water nature.com/articles/s4158…
If you are an highschool student and you are conducting research in a lab, you are a scientist. If you are an undergraduate student and you are conducting research in a lab, you are a scientist.
Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids rdcu.be/ew4uf
Michelle Chang of @PrincetonChem and colleagues publish in @NChemBio: “Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme.” Great work! nature.com/articles/s4158…
From the chin lab Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism | Biochemistry pubs.acs.org/doi/10.1021/ac…
2 of 2: Instead of activating a water molecule for hydrolysis, as previously thought, release factors induce a structural change in the transfer RNA, enabling its own 2’OH group to attack and break the bond, a universal process in all organisms. science.org/doi/10.1126/sc…
Online now! The continuous evolution of biomolecular force fields dlvr.it/TLNb6S
Excited to share our newest paper, online today @Nature! We report the discovery of a highly unusual mechanism of antiviral immunity through the synthesis of long, homopolymeric DNA. nature.com/articles/s4158…
There is also a Colab notebook for EvoBindRare now! Try it and let us know what you think: colab.research.google.com/github/patrick…
RareFold predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, validated in wet lab. A step toward next-gen therapeutics. 📄 biorxiv.org/content/10.110… 💻 github.com/patrickbryant1…
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! nature.com/articles/s4146…
Pushing the bounds of human capability across frontiers of intelligence, space & biotech is a mission I care deeply about. As federal science budgets enter a period of uncertainty - we're excited to step up with $100M for engineers & inventors affected by funding cuts.
1/ We're dedicating $100M to support American scientists facing funding cuts through the Lux Science Helpline, an expansion of our Lux Labs program. To compete in the future, innovation must be funded 🧪💡
Escherichia coli with a 57-codon genetic code biorxiv.org/content/10.110… #biorxiv_synbio
Seeing what bacteria see from a flying UAV 👁️ rdcu.be/ehkQB #synbio #biotech @itai_levin @yonchem
Designing Enzymatic Reactivity with an Expanded Palette "build new enzyme function through the incorporation of noncanonical amino acids and synthetic cofactors" …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…
Chlamydomonas chloroplast genes tolerate compression of the genetic code to just 51 codons biorxiv.org/content/10.110… #biorxiv_synbio
Hijacking a bacterial membrane transporter for efficient genetic code expansion biorxiv.org/content/10.110… #biorxiv_synbio
Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system. biorxiv.org/content/10.110… #biorxiv_synbio
Thrilled (and relieved) to finally have this review by Arianna, Zeyi, and Kaitlyn out! Everything you've ever wanted to know about genetic code expansion in mammalian cells! pubs.acs.org/doi/10.1021/ac…
Engineered cells are finding their way into agriculture, living materials, consumer products and medicines. How do we design these cells and adapt regulatory rules to facilitate their safe and efficient use? #synbio #biotech rdcu.be/d8xLG
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