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In synthetic biology classes, I ask students what biological function they want to create, and one popular answer is "photosynthesis in mammals". Now, it's achieved! The authors transplanted membrane-coated thylakoids into chondrocytes and mice! Congrats! nature.com/articles/s4158…
The demise of a neuron. Source: Mahmoud M. Mahdali #neuroscience #neurotwitter #sciencetwitter #brain #Bioinformatics #neurology #science #medicine #MedTwitter #biotech
1/14 🤔Why does it take weeks for the radiographic evidence of pneumonia to clear? Patients often feel better DAYS after starting treatment. And yet the chest x-ray takes WEEKS to return to normal. Why the delay?
1/16 🤔Why does subarachnoid hemorrhage lead to deep/inverted "cerebral T-waves"? This ECG finding is so dramatic. But as we will see, these patients often have normal hearts. Why does an issue in the brain manifest on a test of the heart?
Rediscovering the poetry part of my brain, with the help of some med school-era work I finally revisited
What is the yield of Head CT for pts presenting with isolated psychiatric complaints? Apparently 0%, if no other indication. @JAMAInternalMed ▶️Retrospective, multicenter study ▶️n=369 pts, non-psych indications excluded ▶️0 explanatory findings found ja.ma/3Oz0Tfe
Interesting presentation of adverse effects of diphenhydramine ☠️ Wondering how this may mold psych's practice of IV/IM diphenhydramine for acute dystonic reactions @preardon
💊💩 Typhlitis, an illness script! 💩💊 "Tuphlon" = Greek for 'cecum or blind gut' -itis = Inflammation! Also called Neutropenic enterocolitis!
Research can be hard, but there are ways to make it simpler. Here are some tips for working in the lab 🧵⬇️
One trick I learned from Tokyo that helps for understanding any city: when you come across a charming small biz in a sea of generic chains, ask them about their relationship with their landlord. For example, this is the fantastic Alabaster Bookshop, near Union Square in NYC...
Published today in Science, a team from CZ Biohub and @MPI_Biochem combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. 🧵 science.org/doi/10.1126/sc…
New preprint🥳‼️ We're thrilled to report how #interferon acts as a bonafide adaptor of #stemcell output to demand in the young and #aging brain 🧠 We combine: ▶️Ribo-Seq, RNA-Seq & phosp-proteome ▶️In-vivo scRNA-Seq ▶️Mathematical modeling 🧵1/ biorxiv.org/content/10.110…
If one page could sum up being in ID right now… #IDtwitter #MedTwitter #TXID #Covid #thankyouforthisconsult
In case your plans for the New Year involve applying for #postdoc #fellowships, maybe this list of potential funders can be helpful: docs.google.com/spreadsheets/d… I try to keep it updated, please let me know if you know of any changes/additions
Now online! Neuronal ensembles in the mouse insular cortex that are activated during distinct inflammatory conditions, are capable of modulating peripheral immunological responses #neuroscience bit.ly/3H2rJKc
Not my field, but it's been fun to watch a bona fide flywheel effect in the genome engineering space the past few weeks New technologies leading to new biological applications, motivating even better technologies and so on ...
My group's first research paper on automated cell type assignment for highly multiplexed imaging data now published in @CellSystemsCP Paper: authors.elsevier.com/a/1dmB38YyDffJ… Tool: github.com/camlab-bioml/a… Some thoughts and updates:
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