#complement search results
🧬#Complement Cascade – Inhibitors 🔹C3 inhibitors •Pegcetacoplan→blocks upstream •Iptacopan, Danicopan🛑C3 convertase 🔹C5 inhibitors •Eculizumab, Ravulizumab, Crovalimab🛑C5→prevent MAC (C5b-9) 🧱Natural regulators: • FH, FI,CD55—⛔C3 convertase • CD59⛔ MAC 📌 #PNH
🔥#Complement system: the silent orchestrator in #kidney #transplant 🧬Classical→ AMR, C-disease relapse 🌿Lectin→ IRI via DAMPs 💥Alternative→ Xeno & innate triggers ⚙️C3/C5 cleavage→MAC→injury 🛡️Regs: C1-INH, Factor H/I, CD46, CD55, CD59 🔗doi.org/10.1093/ndt/gf… #CKD
🔥#Complement in renal allograft injury— immune path of graft loss: 🧬#IRI→ Lectin (MBL/MASPs), DAMP–TLR → cytokines, NK ⚔️#TCMR→ C3a/C5a amplify T/B cells, Th1/Th17↑, Treg↓ 💣#AMR→ DSAs→ classical path→ C4d, MAC, VWF→ injury 🔗 doi.org/10.1093/ndt/gf… #Tx #NephX #MedX
New #openaccess laboratory study. Does #dexmedetomidine help prevent cognitive decline induced by sleep loss via #complement? #sleepdeprivation #complementactivation #anaesthesia #criticalcare bjanaesthesia.org/article/S0007-…
Today's card is Temperance Everything has an opposite, and, if the balance is right, they will complement each other perfectly. #balance #complement #opposite #tarot #tarotmessage #LauraJK32
🚨#Complement Therapy breakthrough in #IgAN Iptacopan slashes proteinuria by 38.3% in Phase 2/3 trials!🎯 ✅ Blocks C3 activation via Factor B ✅ Rapid action (2 weeks) ✅ Safe, no deaths🚫 ✅ Outperforms budesonide Stay tuned for eGFR data📊 📖@KidneyKolumns Jan25 #Nephrology
There is still time to register now for the inaugural KDIGO GEMs (Guideline Education Meetings) on January 13 and 14! This virtual event, available in multiple time zones, will dive into glomerular diseases, including #ANCA-associated vasculitis, #Complement-mediated kidney…
#Complement activation and effector pathways in #membranousnephropathy doi.org/10.1016/j.kint… #KIReview #glomerulonephritis #glomerulus #proteinuria
#Complement and #Podocytopathies: Do We Have a New Biomarker? doi.org/10.1016/j.ekir… Original Article: doi.org/10.1016/j.ekir… #KIRCommentary
#AugustIssue | Michael Holers describes the #complement system and its role in #rheumatic and #autoimmune diseases, and discusses complement #therapeutics in these settings, as well as prospects for improving their clinical use. go.nature.com/3rVoNvH
The #complement #C5 inhibitor #Ravulizumab is a potential new treatment for #IgA nephropathy and proliferative #lupus #nephritis. In a phase 2 trial in IgA nephropathy patients, a statistically significant #proteinuria reduction of −30.1% (90% CI, −43.5% to −13.7%) was…
🤯 Resistant membranous? 🤩 Check out this MABsolutely great Review on future treatment options 💥 Anti #CD20 #CD38 and #complement inhibitors get a special mention… what would your money be on? 👉doi.org/10.1093/ckj/sf… Tweet by @madelena_stauss
Great review paper reporting the promise of complement therapeutics in solid organ transplantation. #TransplantTwitter #Complement #MedTwitter tinyurl.com/3ht36bpk
Out now in @Nature, we find that #GranzymeK activates the entire #complement cascade and contributes to #inflammation across multiple disease states. @Donado_Immuno @AHelenaJonsson1 @BrighamResearch #immunology #rheumatoidarthritis nature.com/articles/s4158…
The role of #complement in #kidneydisease: conclusions from a Kidney Disease: Improving Global Outcomes (#KDIGO) Controversies Conference doi.org/10.1016/j.kint… @UCL @bambinogesu @BUMedicine @unicomplutense @ImperialImmuno @PennKidney @CUDeptMedicine @ClinUnivStLuc #OpenAccess
So proud of @anuja_java receiving the Foundation for Women's Health Grant to study #preeclampsia and #complement pathways. @WashUNephrology @washumedicine See more: bit.ly/4q3in7E
Congratulations to Anuja Java, MD, PhD, Associate Professor of Medicine, @WashUNephrology on her research grant. Dr. Java received the inaugural Foundation for Women’s Health Grant to Study Preeclampsia and Complement Pathways. Learn more > internalmedicine.wustl.edu/anuja-java-rec…
In Brisbane 🇦🇺 for #ICW2025! Delighted to have presented my @UKDRI research on #Complement Receptor 1, recently published in #Alzheimer’s & Dementia (@alzassociation, PMID:40631443). Many thanks to @DMM_Journal, Guarantors of the @Brain1878, @IntlComplement & @cardiffuni 1/2
#thanks for the #complement 3 jobs of complement system Opsinization Pro inflammatory Attack complex #ClinicalPearl #CCRWest24 @ccr
#complement : the quantity or number required to fill a thing or make it complete - French: complète - German: die Ergänzung - Italian: complemento - Portuguese: complemento - Spanish: complementa
A wealth of informational resources & advocacy among #aHUS families worldwide awaits at aHUSallianceAction.org Our aHUS Alliance Global Action team: Connect * Inform * Collaborate. E: [email protected] #cmTMA #complement #atypicalHUS
Rare Disease Advocate Mr. Saurabh Singh shares how families feel isolated during initial AHUS diagnosis & why connecting with support groups is key. Full episode: Kidney Care AHUS Talks | In Association with AHUS & @AstraZeneca 👉 youtube.com/watch?v=nV_6dY… #AHUSAwareness
C3 glomerulonephritis - By Roman Praliaud (fellow in Internal Medicine, Dijon, France) #C3GN #complement #alternative #InternistAcademy 2023
🔥#Complement system: the silent orchestrator in #kidney #transplant 🧬Classical→ AMR, C-disease relapse 🌿Lectin→ IRI via DAMPs 💥Alternative→ Xeno & innate triggers ⚙️C3/C5 cleavage→MAC→injury 🛡️Regs: C1-INH, Factor H/I, CD46, CD55, CD59 🔗doi.org/10.1093/ndt/gf… #CKD
🧬#Complement Cascade – Inhibitors 🔹C3 inhibitors •Pegcetacoplan→blocks upstream •Iptacopan, Danicopan🛑C3 convertase 🔹C5 inhibitors •Eculizumab, Ravulizumab, Crovalimab🛑C5→prevent MAC (C5b-9) 🧱Natural regulators: • FH, FI,CD55—⛔C3 convertase • CD59⛔ MAC 📌 #PNH
#Complement activation and effector pathways in #membranousnephropathy doi.org/10.1016/j.kint… #KIReview #glomerulonephritis #glomerulus #proteinuria
Defining #NephriticFactors as Diverse Drivers of Systemic #Complement #Dysregulation in C3 Glomerulopathy #C3G #VisualAbstract by @DrPallaviPrasad kireports.org/article/S2468-…
#Complement and #Podocytopathies: Do We Have a New Biomarker? doi.org/10.1016/j.ekir… Original Article: doi.org/10.1016/j.ekir… #KIRCommentary
A Prospective Study on #Complement Activation Distinguishes Focal Segmental Glomerulosclerosis #FSGS from Minimal Change Disease #MCD #VisualAbstract by @DrPSVali kireports.org/article/S2468-…
Finally got to meet and listen to the #complement queen 👑!! @WUNephrology is so lucky to have you @anuja_java !! @womeninnephro
New #openaccess laboratory study. Does #dexmedetomidine help prevent cognitive decline induced by sleep loss via #complement? #sleepdeprivation #complementactivation #anaesthesia #criticalcare bjanaesthesia.org/article/S0007-…
🤯 Resistant membranous? 🤩 Check out this MABsolutely great Review on future treatment options 💥 Anti #CD20 #CD38 and #complement inhibitors get a special mention… what would your money be on? 👉doi.org/10.1093/ckj/sf… Tweet by @madelena_stauss
The role of #complement in #kidneydisease: conclusions from a Kidney Disease: Improving Global Outcomes (#KDIGO) Controversies Conference doi.org/10.1016/j.kint… @UCL @bambinogesu @BUMedicine @unicomplutense @ImperialImmuno @PennKidney @CUDeptMedicine @ClinUnivStLuc #OpenAccess
Great review paper reporting the promise of complement therapeutics in solid organ transplantation. #TransplantTwitter #Complement #MedTwitter tinyurl.com/3ht36bpk
Advice _ of _ the _ day... 🙏🏻💝 God created souls to complement each other. Each soul gives from the source of its strength to the other, Don't look for the #similar, but for the #complement ❤️
Clinical Safety and Efficacy of #Pegcetacoplan in a Phase 2 Study of Patients with #C3 Glomerulopathy and Other #Complement-Mediated #Glomerular Diseases #VisualAbstract by @jmteakell kireports.org/article/S2468-…
Today's card is Temperance Everything has an opposite, and, if the balance is right, they will complement each other perfectly. #balance #complement #opposite #tarot #tarotmessage #LauraJK32
Ex-Vivo Test of #Complement Dysregulation in Atypical Hemolytic Uremic Syndrome #aHUS #KidneyTransplant Patients: a Pilot Study #VisualAbstract by @EricAu kireports.org/article/S2468-…
🔥#Complement in renal allograft injury— immune path of graft loss: 🧬#IRI→ Lectin (MBL/MASPs), DAMP–TLR → cytokines, NK ⚔️#TCMR→ C3a/C5a amplify T/B cells, Th1/Th17↑, Treg↓ 💣#AMR→ DSAs→ classical path→ C4d, MAC, VWF→ injury 🔗 doi.org/10.1093/ndt/gf… #Tx #NephX #MedX
#Renin and renin blockade have no role in #complement activity doi.org/10.1016/j.kint… @MORL_UIowa @IowaMed @IowaStateU #OpenAccess #aliskiren
A new alternative: inhibiting #complement activation in patients with #IgA #nephropathy doi.org/10.1016/j.kint… Original article: doi.org/10.1016/j.kint… @RWTH #KICommentary #IgAN #proteinuria #Iptacopan
Les glomérulonéphrites à dépôts de C3 - Par Roman Praliaud (interne de Médecine Interne, Dijon) #GNC3 #complement #voiealterne #InternistAcademy 2023
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