#immunecheckpointblockade search results
Drs. Omar Abdel-Wahab (@AbdelWahablab) and Robert Bradley's (@bradleybio) labs found that drugs that modify RNA splicing can enhance tumor response to #ImmuneCheckpointBlockade. ๐ง @CellCellPress paper: bit.ly/3AFNtZ1 Episode with discussion: bit.ly/3dNchVc
Hainingโs group @NatImmunol study shows exhausted T cells in tumours contain distinct subsets: one is persistent & in response to #immunecheckpointblockade gives rise to short-lived CD8+ T cells that exert tumour control. #ResearchHighlight @NatResCancer go.nature.com/2ChfHwE
IL7 genetic variation and toxicity to #ImmuneCheckpointBlockade in patients with #Melanoma nature.com/articles/s4159โฆ
JULY ISSUE: The Rationale and Emerging Use of #Neoadjuvant #ImmuneCheckpointBlockade for #SolidMalignancies. ow.ly/ZIPM30kswze @JenWargoMD @McMastersKelly @SocSurgOnc
Happy to share our thoughts on what the future holds for oncolytic virotherapy. More data forthcoming in conjunction with #immunecheckpointblockade @MarkTysonMD @cgoncology science.org/content/articlโฆ
AUGUST ISSUE: Neoadjuvant Versus Adjuvant #ImmuneCheckpointBlockade in the Treatment of Clinical #StageIIIMelanoma. #melanoma ow.ly/1c1f50AGLST @McMastersKelly @SocSurgOnc
๐ข Special Research Seminar Join us for a @OhioStateMedOnc @OhioStatePIIO faculty candidate talk featuring Dr. No Joon Song! ๐งฌ "#Tumor-associated #NKcells mediate resistance to #ImmuneCheckpointBlockade therapy" ๐ Tuesday, Sept 9, 2025 ๐ 10โ11 AM ๐ 115 BRT
#Pembrolizumab increased 1-year DFS rate in intermediate-risk, but not high-risk patients with #HNSCC. Pathological response to neoadjuvant #ImmuneCheckpointBlockade is a promising surrogate for DFS. bit.ly/3JnEsrv @TMWiseDraper @ShuchiGulati
Daniel Ajona et al show in @NatureCancer that short-term starvation can sensitize lung tumours in mice to #immunecheckpointblockade through a reduction in circulating IGF1 levels. go.nature.com/2UxDbrf #ResearchHighlight @NatResCancer @CIMA_unav @idisnanavarra @CIBERONC
#ImmuneCheckpointBlockade : @DNAillustration medical illustration on lung inflammation appears on the cover of @JADPRO #Magazine #Oncology #cancer #mAb #pneumonitis #patientcare #medicalillustration #editorial #digital #scientific #health #realistic ow.ly/xVPX30kZjVR
New! ๐ #๐๐ฆ๐ฆ๐ฎ๐ง๐จ๐ญ๐ก๐๐ซ๐๐ฉ๐ฒ ๐๐จ๐ซ #๐ ๐ฅ๐ข๐จ๐๐ฅ๐๐ฌ๐ญ๐จ๐ฆ๐: ๐ญ๐ก๐ ๐ฉ๐ซ๐จ๐ฆ๐ข๐ฌ๐ ๐จ๐ ๐๐จ๐ฆ๐๐ข๐ง๐๐ญ๐ข๐จ๐ง ๐ฌ๐ญ๐ซ๐๐ญ๐๐ ๐ข๐๐ฌ Read more ๐๐ jeccr.biomedcentral.com/articles/10.11โฆ #ImmuneCheckpointBlockade #CancerVaccine @IREISGufficiale
SCI member Carolyn Bertozzi & others produced an anti-tumor immune response by altering sugar molecules on the surface of cancer cells in mice. bit.ly/3UBXJuB @CarolynBertozzi #ImmuneCheckpointBlockade
Our latest POSTER with @NatRevImmunol explores rationale combinations of #immunecheckpointblockade of #PD1-#PDL1, with other therapies aimed at targeting effector T cells, innate immune + regulatory T cells, the #TME & cancer cells. Check it out now! go.nature.com/3WLcCh5
High expression of #Notch pathway genes and Notch signalling are associated with benefit from #immunecheckpointblockade in small cell #lungcancer #CancerResearch by @nitinroper @NCIResearchCtr @NatResCancer go.nature.com/3wUbZDJ
Check out this #COVID19 and #ImmuneCheckpointBlockade perspective by @AACRPres Antoni Ribas and @marinagarassino! #SARSCoV2 #PD1 #PDL1 #AACR21 bit.ly/3g69wjF
How does #melanoma resist #ImmuneCheckpointBlockade? Researchers at @vib_ccb explored the role of TCF4 and cells in a #mesenchymal-like state. @jchrismarine @pozniak_joanna @DennisPedri ๐ @CellCellPress: bit.ly/3Sbg1Et โถ๏ธ: bit.ly/3SlDqTU
How #antiangiogenic agents can normalize the #TumorMicroEnvironment and improve the response to #ImmuneCheckpointBlockade - a review @NatRevClinOncol goo.gl/tZ9UcC
Kristin DePeaux & Greg Delgoffe (@DelgoffeLab) discuss the metabolic aspects of the antitumor T cell response in the context of #ImmuneCheckpointBlockade, adoptive cell therapy and treatment with oncolytic viruses. ๐ @NatRevImmunol: go.nature.com/2PFdgOA
๐ฉโ๐ฌ Investigators report a potent synergy between selective SIRPฮฑ blockade and #ImmuneCheckpointBlockade in increasing memory T cell responses and reverting exclusion in syngeneic and orthotopic tumor models. bit.ly/3dKGALd
Take a look how use of WEE1 and AKT inhibitors affects tumor immune infiltration and efficacy of #ImmuneCheckpointBlockade in #melanoma, in this study by Saketh Dinavahi, @Dr_Nick_Bikes, Gavin Robertson et al. bit.ly/3Olyh9I @S_Foroutan
๐ข Special Research Seminar Join us for a @OhioStateMedOnc @OhioStatePIIO faculty candidate talk featuring Dr. No Joon Song! ๐งฌ "#Tumor-associated #NKcells mediate resistance to #ImmuneCheckpointBlockade therapy" ๐ Tuesday, Sept 9, 2025 ๐ 10โ11 AM ๐ 115 BRT
Recently published: Evaluating Gene Fusions as Prognostic Biomarkers and Therapeutic Targets in #ImmuneCheckpointBlockade-Treated #AdvancedMelanoma: A Retrospective Analysis, by Guadalupe Nibeyro et al. doi.org/10.1158/2767-9โฆ #Melanoma #OpenAccess
Online!๐น Integrated multi-omics profiling reveals the role of the #DNAmethylation landscape in shaping biological heterogeneity and clinical behaviour of #metastaticmelanoma Look here๐ก jeccr.biomedcentral.com/articles/10.11โฆ #ImmuneCheckpointBlockade #DNMTinhibitor
New Review!๐ฅณ Multiple mechanisms and applications of #tertiarylymphoidstructures and #immunecheckpointblockade Look hereโคต๏ธ jeccr.biomedcentral.com/articles/10.11โฆ #ImmuneEscape #Immunotherapy
Recently published: Depletion of #adipose stroma-like cancer-associated fibroblasts potentiates #pancreaticcancer immunotherapy, by Joseph Rupert et al. doi.org/10.1158/2767-9โฆ @drdavidroad @zzhao_bioinfo @McGovernMed @UTHealthHouston #ImmuneCheckpointBlockade #openaccess
Recently published: Spatial context of #immunecheckpoints as predictors of overall survival in patients with resectable #colorectalcancer independent of standard TNM stages, by Hao Kong et al. doi.org/10.1158/2767-9โฆ @jiangh7 #ImmuneCheckpointBlockade #openaccess
Our latest POSTER with @NatRevImmunol explores rationale combinations of #immunecheckpointblockade of #PD1-#PDL1, with other therapies aimed at targeting effector T cells, innate immune + regulatory T cells, the #TME & cancer cells. Check it out now! go.nature.com/3WLcCh5
A carrier-free photodynamic bioregulator (CASN) was developed to complement #ImmuneCheckpointBlockade therapy and improve immunotherapeutic efficacy against #TripleNegativeBreastCancer by reprogramming the lactic acid #TumorMicroenvironment. Read: go.acs.org/air
TRP-2 / gp100 DNA vaccine and PD-1 checkpoint blockade combination for the treatment of intracranial tumors: link.springer.com/article/10.100โฆ #CancerVaccine #ImmuneCheckpointBlockade
link.springer.com
TRP-2 / gp100 DNA vaccine and PD-1 checkpoint blockade combination for the treatment of intracran...
Cancer Immunology, Immunotherapy - Intracranial tumors present a significant therapeutic challenge due to their physiological location. Immunotherapy presents an attractive method for targeting...
3/ LORIS demonstrates a near-monotonic relationship with #ImmuneCheckpointBlockade (#ICB) response probability and patient survival, providing a reliable way to identify likely responders and exclude non-responders to #immunotherapy.
Online now!๐ฒ Inhibition of #autophagy-related protein 7 enhances anti-tumor #immuneresponse and improves efficacy of #immunecheckpointblockade in microsatellite instability #colorectalcancer Full text๐ jeccr.biomedcentral.com/articles/10.11โฆ #Cholesterol #Microsatelliteinstability
Online!๐ฒ Blood-based biomarkers in patients with #nonsmallcelllungcancer treated with #immunecheckpointblockade Full textโคต๏ธ jeccr.biomedcentral.com/articles/10.11โฆ #Liquidbiopsy #Immunotherapy
Gut bacteria strains could be the key to predicting cancer treatment success ๐งฌ๐ฌ๐ฏ news-medical.net/news/20240306/โฆ #GutMicrobiota #CancerTherapy #ImmuneCheckpointBlockade #PredictiveMedicine #NatureMedicine #RareCancers #PersonalizedTreatment #Microbiome @NatureMedicine
How does #melanoma resist #ImmuneCheckpointBlockade? Researchers at @vib_ccb explored the role of TCF4 and cells in a #mesenchymal-like state. @jchrismarine @pozniak_joanna @DennisPedri ๐ @CellCellPress: bit.ly/3Sbg1Et โถ๏ธ: bit.ly/3SlDqTU
Happy to share our thoughts on what the future holds for oncolytic virotherapy. More data forthcoming in conjunction with #immunecheckpointblockade @MarkTysonMD @cgoncology science.org/content/articlโฆ
Online!๐ฒ CD28/PD1 co-expression: dual impact on CD8+ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response Look here๐ jeccr.biomedcentral.com/articles/10.11โฆ #Nonsmallcelllungcancer #ImmuneCheckpointBlockade @IREISGufficiale
.@MSKLibrary feature: Novel Genetic Subtypes of Urothelial Carcinoma w/Differential Outcomes on #ImmuneCheckpointBlockade @MichalSarfaty @MSK_DeptOfMed @MSKPathology @AMRegazzi @MSKBiostats @illumina @bengrbm @DrRosenbergMSK @GeneCollector @JCO_ASCO dx.doi.org/10.1200/JCO.22โฆ
He is sharing his work on rationally combining BiTE - T cell therapy & #immunecheckpointblockade. #CMSSJI #CancerMoonshotSeminar
How do bacteria affect #ImmuneCheckpointBlockade? ๐ฆ Researchers at @GustaveRoussy investigated if bacteria that rebound after antibiotics are administered affect cancer treatment responses. @ScienceMagazine paper: bit.ly/3PB3gCe Discussion: bit.ly/3CKoohP
Latest issue!โญ๏ธ Metastatic lymph node targeted CTLA4 blockade: a potent intervention for local and distant metastases with minimal ICI-induced pneumonia For free๐ฝ jeccr.biomedcentral.com/articles/10.11โฆ #Metastaticlymphnode #Interstitialpneumonia #Immunecheckpointblockade @IREISGufficiale
AUGUST ISSUE: Neoadjuvant Versus Adjuvant #ImmuneCheckpointBlockade in the Treatment of Clinical #StageIIIMelanoma. #melanoma ow.ly/1c1f50AGLST @McMastersKelly @SocSurgOnc
JULY ISSUE: The Rationale and Emerging Use of #Neoadjuvant #ImmuneCheckpointBlockade for #SolidMalignancies. ow.ly/ZIPM30kswze @JenWargoMD @McMastersKelly @SocSurgOnc
#ImmuneCheckpointBlockade : @DNAillustration medical illustration on lung inflammation appears on the cover of @JADPRO #Magazine #Oncology #cancer #mAb #pneumonitis #patientcare #medicalillustration #editorial #digital #scientific #health #realistic ow.ly/xVPX30kZjVR
IL7 genetic variation and toxicity to #ImmuneCheckpointBlockade in patients with #Melanoma nature.com/articles/s4159โฆ
She is showing collaborative work with @MathCancer. They found that immune aggregates from #immunecheckpointblockade limit immune cell trafficking into tumors via computational modeling. #AACR23
Hainingโs group @NatImmunol study shows exhausted T cells in tumours contain distinct subsets: one is persistent & in response to #immunecheckpointblockade gives rise to short-lived CD8+ T cells that exert tumour control. #ResearchHighlight @NatResCancer go.nature.com/2ChfHwE
Gut bacteria strains could be the key to predicting cancer treatment success ๐งฌ๐ฌ๐ฏ news-medical.net/news/20240306/โฆ #GutMicrobiota #CancerTherapy #ImmuneCheckpointBlockade #PredictiveMedicine #NatureMedicine #RareCancers #PersonalizedTreatment #Microbiome @NatureMedicine
Drs. Omar Abdel-Wahab (@AbdelWahablab) and Robert Bradley's (@bradleybio) labs found that drugs that modify RNA splicing can enhance tumor response to #ImmuneCheckpointBlockade. ๐ง @CellCellPress paper: bit.ly/3AFNtZ1 Episode with discussion: bit.ly/3dNchVc
#Pembrolizumab increased 1-year DFS rate in intermediate-risk, but not high-risk patients with #HNSCC. Pathological response to neoadjuvant #ImmuneCheckpointBlockade is a promising surrogate for DFS. bit.ly/3JnEsrv @TMWiseDraper @ShuchiGulati
High expression of #Notch pathway genes and Notch signalling are associated with benefit from #immunecheckpointblockade in small cell #lungcancer #CancerResearch by @nitinroper @NCIResearchCtr @NatResCancer go.nature.com/3wUbZDJ
Check out this #COVID19 and #ImmuneCheckpointBlockade perspective by @AACRPres Antoni Ribas and @marinagarassino! #SARSCoV2 #PD1 #PDL1 #AACR21 bit.ly/3g69wjF
Our latest POSTER with @NatRevImmunol explores rationale combinations of #immunecheckpointblockade of #PD1-#PDL1, with other therapies aimed at targeting effector T cells, innate immune + regulatory T cells, the #TME & cancer cells. Check it out now! go.nature.com/3WLcCh5
New! ๐ #๐๐ฆ๐ฆ๐ฎ๐ง๐จ๐ญ๐ก๐๐ซ๐๐ฉ๐ฒ ๐๐จ๐ซ #๐ ๐ฅ๐ข๐จ๐๐ฅ๐๐ฌ๐ญ๐จ๐ฆ๐: ๐ญ๐ก๐ ๐ฉ๐ซ๐จ๐ฆ๐ข๐ฌ๐ ๐จ๐ ๐๐จ๐ฆ๐๐ข๐ง๐๐ญ๐ข๐จ๐ง ๐ฌ๐ญ๐ซ๐๐ญ๐๐ ๐ข๐๐ฌ Read more ๐๐ jeccr.biomedcentral.com/articles/10.11โฆ #ImmuneCheckpointBlockade #CancerVaccine @IREISGufficiale
Daniel Ajona et al show in @NatureCancer that short-term starvation can sensitize lung tumours in mice to #immunecheckpointblockade through a reduction in circulating IGF1 levels. go.nature.com/2UxDbrf #ResearchHighlight @NatResCancer @CIMA_unav @idisnanavarra @CIBERONC
Today #readoftheweek๐looks at patients with advanced #HCC who are non-responders to #ImmuneCheckpointBlockade monotherapy. ๐Read here this open-access JHEP Reports: bit.ly/2Qoa2yG #livetwitter
Here we showed that tretinoin induces an #inflammatory tumor microenvironment and increases CD8 infiltration. Pre-treating tumors with tretinion before #immunecheckpointblockade increases survival and response rate in murine models of #mesothelioma and #sarcoma
SCI member Carolyn Bertozzi & others produced an anti-tumor immune response by altering sugar molecules on the surface of cancer cells in mice. bit.ly/3UBXJuB @CarolynBertozzi #ImmuneCheckpointBlockade
RT @CIR_AACR: #TumorMutationalBurden differs between #SquamousCell carcinomas (SCCs) and non-SCCs. Find out how mutational burden together with histology in cutaneous disease correlate with patient outcome after #ImmuneCheckpointBlockade. bit.ly/2Iosm34
New!๐ฅ ๐๐ฆ๐๐ซ๐ ๐ข๐ง๐ ๐ญ๐ก๐๐ซ๐๐ฉ๐ข๐๐ฌ ๐๐จ๐ซ #๐ ๐ฅ๐ข๐จ๐๐ฅ๐๐ฌ๐ญ๐จ๐ฆ๐: ๐๐ฎ๐ซ๐ซ๐๐ง๐ญ ๐ฌ๐ญ๐๐ญ๐ ๐๐ง๐ ๐๐ฎ๐ญ๐ฎ๐ซ๐ ๐๐ข๐ซ๐๐๐ญ๐ข๐จ๐ง๐ฌ Enjoy your reading โฌ jeccr.biomedcentral.com/articles/10.11โฆ #Immunotherapy #ImmuneCheckpointBlockade @IREISGufficiale
NEW #ResearchHighlight! Li, Xiao and colleagues show that #Antihistamines might increase the efficacy of #ImmuneCheckpointBlockade. ๐ฏ go.nature.com/3dQP4RF @natrescancer
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