#rcts search results
Ever wondered if #RCTs results are truly robust? 📊📈 Fragility index may be the solution! Find out more in the latest Statistical Spotlight from #EHJACVC 👇 bit.ly/3JT2YTc
Are there differences in outcomes between limus vs paclitaxel #DCBs? 🤔 This meta-analysis of 6 #RCTs showed no difference in clinical outcomes! bit.ly/4cDlQm7 #JACCINT
We completed an IPDMA of #RCTs of #bivalirudin vs #heparin in #MI. Took >5 Ys!⏲️ #STEMI results in @JACCjournals. Consistent w BRIGH4, bival+high-dose post-PCI infusion ⬇️🩸⬇️ CVdeath @GreggWStone @crfheart: jacc.org/doi/10.1016/j.… Design: thieme-connect.com/products/ejour… @TH_Journal
Compelling evidence that if clinical trialists interested in the impact of treatment on health-related #qualityoflife include only generic measures and fail to include responsive and valid disease-specific measures in their #RCTs, they risk missing the crucial signal.
Lp(a) ⬆️the risk of ASCVD, but how about #VTE??🤔 🚨We summarize the existing pathophys & epidemiological data in @TH_Journal w an 👁️toward findings from #RCTs: thieme-connect.com/products/ejour… Great work #MarianaPfeferman🙏🙏 to 🌟team! #Cardiology #Lipids
Check out the results from an individual-patient-data pooled analysis from 5 #RCTs investigating the Absorb bioresorbable vascular scaffold compared to #DES in 5,988 pts undergoing #PCI jacc.org/doi/10.1016/j.… #JACCINT #BVS @GreggWStone
In our SRMA of #RCTs #statins 💊 seemed safe in pts w #cancer. Key ❓is whether they also confer extra benefit ✅ for cardiovascular outcomes. #thrombosis Great working with @farbod_ZT @connors_md @BrighamResearch Link👇 buff.ly/3XmIomi
How serious is the risk of myopathy and hepatotoxicity in patients with cancer receiving #statin 💊? Find out in our latest systematic review below 👇 Grateful for rockstar🌟 mentors @bbikdeli and @connors_md journals.sagepub.com/doi/10.1177/13…
#CompositeEndpoints in #RCTs: big problem. #BMJ survey of use in #cardiovascular trials: they make results look more important than they are through impression of benefits in death when only real effect in much less important outcomes (e.g. stent placement)
Just-published survey #simulation studies: how should #RCTs with binary outcomes address #MissingData? Multiple imputation best, single imputation, complete case less well. Data missing not at random, typical situation, nothing works well. Missing data risks #bias, too bad.
Authors of #RCTs who actually apply concealed #randomization and #blinding failed to report transparently in their articles. Making correct deductions requires inferences from clues in the study, contacting authors to get definitive information. pubmed.ncbi.nlm.nih.gov/15617948/
Discontinued randomized control trials (#RCTs) a problem. This #JAMA article presents the prevalence (almost 25%), characteristics (most frequently due to poor recruitment), & publication status (odds ratio>3 of not being published) of discontinued RCTs. pubmed.ncbi.nlm.nih.gov/24618966/
Advocates suggest administrative real-world data can substitute for #RCTs and offer propensity matching to reduce bias. But results often fail to correspond: #BMJ study showed direction of effect differed in 31% & CI failed to include #RCT estimate in 56% pubmed.ncbi.nlm.nih.gov/26858277/
RCTs don't often tell the whole story w their primary publication. In @JACCJournals @RosselloXavier @DLBHATTMD et al do a systematic survey of #extension reports of🫀#RCTs: jacc.org/doi/10.1016/j.… In the Editorial, we discuss the Dos & Don'ts👇: jacc.org/doi/10.1016/j.…
Recent @cochranecollab Colombia Webinar: new #RiskofBias instrument for #RCTs, ROBUST-RCT @bmj_latest publication this year. Talk shows how ROBUST-RCT maintains rigor while achieving user-friendliness and simplicity. Prediction: ROBUST will become the go-to #instrument. #BMJ
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Teleducación Facultad de Medicina UdeA
Live @SIRspecialists @SCAI Tune In next tuesday for a deep dive on all things re: Pulmonary Embolism. An expert panel will provide updates on completed and ongoing #RCTs for Endovascular Therapy. This is the place to get the latest expert perspectives. connect.sirweb.org/events/event-d…
🚀 when observation meets randomisation. Dive into the intersection of #RCTs and #RealWorld data in #HeartFailure & the challenges to innovate and adapt clinical trials doi.org/10.1002/ejhf.3… #HeartFailure #cardioX #EJHF @HFA_President @_antocannata @HanCardiomd @DjawidHashemi
Why is diversity at the ❤️ of today’s #ESCardioCRT discussion in Vienna? Clinical trialist Prof. Faiez Zannad explains why ESC experts and industry representatives are digging into the diversity issue for the future of #RCTs 👇 #RedesignRCTs #cardiotwitter
Explanatory or mechanistic #RCTs of physical or psychological interventions requires “#placebo,” or “#sham” comparators. This #BMJ article presents recommendations for designing, and reporting comparator interventions as well as a reporting checklist bmj.com/content/381/bm…
#ESCPatientForum member Richard Mindham shares four key actions to increase diversity in #RCTs: ✅Build capacity in India and Africa ✅Involve more patients in steering committees ✅Improve trust ✅Reduce inclusion criteria #ESCardioCRT #RedesignRCTs
Randomized trials in individual patients – N of 1 #RCTs - remain underutilized. This @AnnalsofIM paper describes our initial experience with 57 N of 1 RCTs. In 15, results prompted patients and clinicians to alter their treatment plans. pubmed.ncbi.nlm.nih.gov/2297206/
Why do some RCTs change stroke practice overnight while others don’t? Our new @StrokeAHA commentary examines the epistemology of #stroke #RCTs, and highlights the adoption (or not) of trial evidence through 4 clinical scenarios. doi.org/10.1161/STROKE…
Another major milestone for EASY-AS! 🎉 We have now randomised 1,100 participants in the UK! @LeicesterCTU @TheBHF @HeartNZ @gavinjamesmurph #EASYAS #RCTs #ClinicalTrials #ClinicalResearch #Study #AorticStenosis #AS #Heart #Cardiology #Celebrate #Milestone #UK #1100th
#RCTs are essential for evaluating new treatments, yet ~20–25% are discontinued early (@JClinEpi). We surveyed researchers using EmbracePlus 👉92% achieved ≥75% completion. Better participant experience and onboarding can support sustained engagement. 🔗 bit.ly/48nHquO
The importance of #RCTs on the effects of exercise training in #cardiacrehab 🏃🏋🏻♀️ 👨🎓Prof. Rod Taylor kicks of the second day at the #ESCPrev26 in Linhart room.
The #CardioHealth Alliance aims to improve care for patients w/ cardiovascular, renal, & metabolic diseases. @JavedButler1 & others share their expertise on multiorgan #RCTs for holistic treatments of these connected diseases in @JACCJournals 🔗doi.org/10.1016/j.jacc…
The #CardioHealth Alliance aims to use real-world data to inform real-world care. Dr. Andrea Cherrington @UABHeersink highlights the importance of the Alliance’s work to expand access to #RCTs & bridge the gap between research findings & health care 🎥 youtu.be/F71YpqAu7B4
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Duke Clinical Research Institute
Does the #USFedGovt do #RCTs - clinical drug trials - too & w vast new data sets, #AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSchs #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too & w vast new data sets, #AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSchs #WUaScountries?
Does the #USFedGovt do #RCTs - clinical drug trials - too & w vast new data sets, #AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSchs #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too & w vast new data sets, #AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSchs #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too & w vast new data sets, #AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSchs #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too, & w vast new data sets, AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSch #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too, & w vast new data sets, AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSch #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too, & w vast new data sets, AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSch #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too, & w vast new data sets, AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSch #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
Does the #USFedGovt do #RCTs - clinical drug trials - too, & w vast new data sets, AIandMLwuAs? Yes: 1 gemini.google.com/share/18dce658… 2 share.google/aimode/ha7mXp5… How could @WorldUnivAndSch collaborate & w a #RealisticVirtualEarthForClinicalTrials & in all ~200 #WUaSMedSch #WUaScountries?
DATA REPRODUCED: In old female mice, NMN restores ovarian follicle reserve in 10 days. Optimal dose was 200-500 mg/kg body weight/day. Equivalent to 35-45 in woman years. Clinical trials are needed 🐭🧓
This J-PAL policy insight synthesizes findings from eleven #RCTs demonstrating that informational “nudges” increase health insurance enrollment 📋 povertyactionlab.org/policy-insight…
Want to learn more about #RCTs? Check out our #ResearchResources on the elements of randomized evaluations for an intro to theory of change, measurement, study design, data analysis & more! povertyactionlab.org/resource/eleme…
Results from well-designed #RCTs are important for informing policy making, regardless of the result. But null results can be difficult to act on. Learn more about how to think about designing & learning from studies with null results in this blog post: povertyactionlab.org/blog/11-8-24/n…
Let’s talk Housing First 🏠 Our @JPAL brief reviews the literature on several #RCTs to unpack the impact of Housing First programs on housing stability, criminal legal involvement, health, employment, & general findings on cost-effectiveness 💰 Read more: povertyactionlab.org/publication/po…
ERJ: #RCTs in #respiratory medicine require harmonisation. A core outcome set #COS is an agreed minimum set of outcomes that are critical for decision-making and should be evaluated in all future clinical trials. bit.ly/3XQmbtH
Ever wondered if #RCTs results are truly robust? 📊📈 Fragility index may be the solution! Find out more in the latest Statistical Spotlight from #EHJACVC 👇 bit.ly/3JT2YTc
The battle of the sexes. Are #RCTs results generalisable between males and females? bit.ly/43f8ozr @HFA_President #EJHF @EJHFEiC @_antocannata @MarcoMetra @kevin_damman
Spin and fragility in randomised controlled trials in the anaesthesia literature. Should results of RCTs be presented differently? New systematic review by Demarquette et al #statistics #RCTs #fragility bjanaesthesia.org/article/S0007-…
This meta-analysis of #RCTs demonstrates that PRP may confer pain and function benefits in the setting of rotator cuff disease. #PRP #Shoulder #Meta-analysis ow.ly/oPcF50Mx9rH
Are there differences in outcomes between limus vs paclitaxel #DCBs? 🤔 This meta-analysis of 6 #RCTs showed no difference in clinical outcomes! bit.ly/4cDlQm7 #JACCINT
With you @DrMarthaGulati for bringing change for representation of women in #Cardiology trials! Asked the question at @AHAScience #AHA23👇why do we allow <50% women recruited in #RCTs to be accepted? #savingwomenshearts #GoRed #29daysofRed
FACTS! Women make up a small % of #cardiology trials We can change this by: ♥️enrolling into trials ♥️demanding federal funding ensures women are represented ♥️the biggest journals not publish trials that exclude 52% of the population. #savingwomenshearts #GoRed #29daysofRed
buff.ly/3LIiYIT Watchful waiting to surgery in men with mildly symptomatic or asymptomatic #InguinalHernia: an individual participant data meta-analysis of long-term follow-up of #RCTs. #HerniaSurgery #GroinHernia
A collection of #ResearchResources from @JPAL_NA provides guidance for researchers conducting #RCTs in health care. Topics include: 📑Publishing in a medical journal 🏥Navigating hospital IRBs 🔢Power calculations for health-related studies j-p.al/p11
We completed an IPDMA of #RCTs of #bivalirudin vs #heparin in #MI. Took >5 Ys!⏲️ #STEMI results in @JACCjournals. Consistent w BRIGH4, bival+high-dose post-PCI infusion ⬇️🩸⬇️ CVdeath @GreggWStone @crfheart: jacc.org/doi/10.1016/j.… Design: thieme-connect.com/products/ejour… @TH_Journal
In our SRMA of #RCTs #statins 💊 seemed safe in pts w #cancer. Key ❓is whether they also confer extra benefit ✅ for cardiovascular outcomes. #thrombosis Great working with @farbod_ZT @connors_md @BrighamResearch Link👇 buff.ly/3XmIomi
How serious is the risk of myopathy and hepatotoxicity in patients with cancer receiving #statin 💊? Find out in our latest systematic review below 👇 Grateful for rockstar🌟 mentors @bbikdeli and @connors_md journals.sagepub.com/doi/10.1177/13…
Lp(a) ⬆️the risk of ASCVD, but how about #VTE??🤔 🚨We summarize the existing pathophys & epidemiological data in @TH_Journal w an 👁️toward findings from #RCTs: thieme-connect.com/products/ejour… Great work #MarianaPfeferman🙏🙏 to 🌟team! #Cardiology #Lipids
bit.ly/4fdCdr9 Prophylactic mesh reinforcement versus primary suture for abdominal wall closure after elective #AAA repair with midline laparotomy incision: Updated systematic review including time-to-event meta-analysis and trial sequential analysis of #RCTs.
Will this ADHD medication help my patient? Bridging the gap between efficacy & effectiveness buff.ly/4h4Df8Y Is it time to reconsider the value we place on RCTs when they do not include the vast majority of people who need help? #ADHD #Medication #RCTs
On #WomensHealthResearchDay a reminder for everyone👇stated similar introducing my @AHAScience #AHA23 presentation👉 "we have 50% as cut off for pass for exams but allow #RCTs to include <50% #women😞 #TimeForChange
Women represent 51% of the nation’s population. Women are not a niche market. On #WomensHealthResearchDay, SWHR once again celebrates the White House Initiative on Women’s Health Research and looks forward to advances in the federal research landscape: ow.ly/8KVW50Qu4yB
How do you match tMCS to hemodynamics in #cardiogenicshock? @ebohula shares key insights & lessons from #RCTs @ddbergMD @ankeetbhatt @jameshorowitzmd @carlosalviar @JasonKatzMD @BalimSenmanMD @manreetkanwar #critcarecards23
We can’t enroll in #SLE #RCTs Fixes #Pragmatic active A vs B ?emulation studies Adaptive design Shorten trial duration to 6/12 in nonrenal RCTs Withdrawal of #prednisone Flare prevention RCTs Not addressing actual pts @RheumNow #LUPUS2025
Combination advanced #therapies in #IBD Need the #RCTs but it is the way forward for some Pts #Mentoring in #IBD XXV @ScopeCanMD
Check out the results from an individual-patient-data pooled analysis from 5 #RCTs investigating the Absorb bioresorbable vascular scaffold compared to #DES in 5,988 pts undergoing #PCI jacc.org/doi/10.1016/j.… #JACCINT #BVS @GreggWStone
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