#spironolactone search results
12b) #Spironolactone has been shown to be the best 4th line agent at reducing #BP in pts with #RH, as shown in the Prevention & Treatment of Hypertension With Algorithm based therapY-2 (PATHWAY-2) trial. 🔓 pubmed.ncbi.nlm.nih.gov/26414968/ #VisualAbstract by @ChristianMuM @NephJC
Spironolactone is a common treatment for acne in women but there has been a paucity of evidence from RCTs. This placebo-controlled trial showed that #spironolactone improved #acne, especially at week 24. bmj.com/content/381/bm…
#Spironolactone Use and Improved Outcomes in Patients With #HFpEF With Resistant #Hypertension #HeartFailure2023 @escardio
#Spironolactone vs #Amiloride for Resistant Hypertension A Randomized Clinical Trial N = 118 (1:1 randomization) 📍 12-week home #SBP ↓: • Amiloride: −13.6 mm Hg • Spironolactone: −14.7 mm Hg 📍 Between-group difference: −0.68 mm Hg (90% CI −3.50 to 2.14) ✅…
That moment when 1 month after your doctor says... Stop taking your prescription #Spironolactone medication. Waking up after a good sleep feeling more GLORIOUS than you've been in a long time is defo no longer embarrassing or annoying!!! 😊😆😆👍
If I knew what I know now about spironolactone I would have never taken it. It changed my life forever. #spironolactone #informedconsent
For #medstudents who have patients with #ascites, the combination of #spironolactone (aldosterone antagonist) and #furosemide (loop diuretic) in a 5:2 ratio (initially 100mg spiro and 40mg furosemide) leads to improved diuresis and normokalemia #hepatology
#CLEAR SYNERGY trial : Routine #Spironolactone in #AMI Spironolactone vs. placebo in 7062 post-MI patients (median follow-up: 3 years): 📍Primary outcomes: 📌CV death/new HF: 1.7 vs. 2.1 events/100 patient-years (HR 0.91, 95% CI 0.69–1.21, P=0.51) 📌MI, stroke, CV death/new HF:…
For your weekend reading pleasure: A State of the Art Review from @AgarwalRajivMD et al on on-steroidal mineralocorticoid receptor antagonists #Finerenone #Spironolactone
Dual therapy was not inferior to triple therapy and quadruple therapy in terms of cardiac death in dogs with ACVIM stage C myxomatous mitral valve disease. Learn more: jav.ma/acvimstagec #congestiveheartfailure #furosemide #spironolactone #pimobendan
There is hope for #women with Acne😊, Spironolactone is a common treatment for hypertension and heart failure. However there is paucity of data on its use in the treatment of Acne. This placebo-controlled trial showed that #spironolactone improved #acne, especially at week 24.
Overall, smoking weed while taking spironolactone should be safe in most instances, but please be cautious as both drugs may cause low blood pressure. #CannaBuff #spironolactone #cannabisinteractions #druginteractions
The #Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (#SPIRRIT-HFpEF): Rationale and design onlinelibrary.wiley.com/doi/full/10.10… #HFpEF @ESC_Journals @EJHFEiC
🔥 #REALIZE_K : Sodium Zirconium cycloSilicate, hyperkalaemia & #spironolactone in #HFrEF 🧂 Highlighting the opportunity offered by this enable to introduce #MRA 🍀 #HFUA 🫀 @AndrewJSauer @DrMarthaGulati @markcpetrie20 @MicheleEmdin @ESC_Journals bit.ly/4oPJ7rh
Sodium zirconium cyclosilicate, hyperkalaemia, and spironolactone optimization in #heartfailure with reduced ejection fraction: The #REALIZE_K open-label run-in phase @ESC_Journals @GiuseppeGalati_ @AmrAbdin10 @HanCardiomd bit.ly/3HmmDxw
A study in @JAADjournals assessed the trends in potassium monitoring among females with #acne receiving #spironolactone. Results showed that 73% of the patients had their potassium levels checked within 180 days of starting spironolactone... aad.org/dw/weekly/augu…
Fun fact I started gender affirming hormone therapy in 8th grade BY ACCIDENT! 😂 #cysticacne #spironolactone #acne #storytime #trans #transgender
A study published in @JAADjournals assessed the trends in potassium monitoring among females with #acne receiving #spironolactone. The results showed that 73% of the patients had their potassium levels checked within 180 days of starting spironolactone... aad.org/dw/weekly/augu…
12d) cont 👉Hypotension, falls, bradycardia (~4-5%) 👉 #Gynecomastia ♂️, menstrual irregularities ♀️, ⬇️libido, & sexual dysfunction, esp w/long-term use. Laboratory monitoring (K+, Na+, renal function) is warranted for pts taking #spironolactone. See 🔓pubmed.ncbi.nlm.nih.gov/33682538/
12c) Unfortunately, #MRAs like #spironolactone carry risk of important adverse events, including 👉Hyperkalemia (16%) 👉Acute kidney injury #AKI (15%) 👉Drug interactions (9%) 👉Hyponatremia (8%) 👉Dehydration (6%) cont
12b) #Spironolactone has been shown to be the best 4th line agent at reducing #BP in pts with #RH, as shown in the Prevention & Treatment of Hypertension With Algorithm based therapY-2 (PATHWAY-2) trial. 🔓 pubmed.ncbi.nlm.nih.gov/26414968/ #VisualAbstract by @ChristianMuM @NephJC
12d) cont 👉Hypotension, falls, bradycardia (~4-5%) 👉 #Gynecomastia ♂️, menstrual irregularities ♀️, ⬇️libido, & sexual dysfunction, esp w/long-term use. Laboratory monitoring (K+, Na+, renal function) is warranted for pts taking #spironolactone. See 🔓pubmed.ncbi.nlm.nih.gov/33682538/
12c) Unfortunately, #MRAs like #spironolactone carry risk of important adverse events, including 👉Hyperkalemia (16%) 👉Acute kidney injury #AKI (15%) 👉Drug interactions (9%) 👉Hyponatremia (8%) 👉Dehydration (6%) cont
12b) #Spironolactone has been shown to be the best 4th line agent at reducing #BP in pts with #RH, as shown in the Prevention & Treatment of Hypertension With Algorithm based therapY-2 (PATHWAY-2) trial. 🔓 pubmed.ncbi.nlm.nih.gov/26414968/ #VisualAbstract by @ChristianMuM @NephJC
#Aldactone (Generic #Spironolactone Tablets) is used to treat #highbloodpressure and #heartfailure. Also also used to treat swelling (#edema) caused by certain conditions. #hypertension theswisspharmacy.com/product/aldact…
That moment when 1 month after your doctor says... Stop taking your prescription #Spironolactone medication. Waking up after a good sleep feeling more GLORIOUS than you've been in a long time is defo no longer embarrassing or annoying!!! 😊😆😆👍
who the fuck thought it was funny to make testosterone blockers make you pee every five fucking minutws IW ANT NAMES #spironolactone is EVIL
Shanna Miranti, MPAS, PA-C and Hilary Baldwin, MD review two challenging #acne cases, including that of a young male who did not want to take #isotretinoin and one of a woman who wanted to stop her #spironolactone and become pregnant. jdnppa.com/videos/grand-r…
Shanna Miranti, MPAS, PA-C and Hilary Baldwin, MD review two challenging #acne cases, including that of a young male who did not want to take #isotretinoin and one of a woman who wanted to stop her #spironolactone and become pregnant. thedermdigest.com/videos/grand-r…
@MoarSahitoPTI Spironolactone helps heart failure by reducing LV hypertrophy & mortality (RALES study), balances potassium to counter digoxin toxicity, but efficacy with beta-blockers needs more study. #HeartFailure #Spironolactone #MedicalResearch
Dual therapy was not inferior to triple therapy and quadruple therapy in terms of cardiac death in dogs with ACVIM stage C myxomatous mitral valve disease. Learn more: jav.ma/acvimstagec #congestiveheartfailure #furosemide #spironolactone #pimobendan
🔥 #REALIZE_K : Sodium Zirconium cycloSilicate, hyperkalaemia & #spironolactone in #HFrEF 🧂 Highlighting the opportunity offered by this enable to introduce #MRA 🍀 #HFUA 🫀 @AndrewJSauer @DrMarthaGulati @markcpetrie20 @MicheleEmdin @ESC_Journals bit.ly/4oPJ7rh
Sodium zirconium cyclosilicate, hyperkalaemia, and spironolactone optimization in #heartfailure with reduced ejection fraction: The #REALIZE_K open-label run-in phase @ESC_Journals @GiuseppeGalati_ @AmrAbdin10 @HanCardiomd bit.ly/3HmmDxw
#Spironolactone does not lower cardiovascular risk in #Dialysis patients and increases the risk of severe hyperkalemia, according to the largest trial to date in this population. @mcmastereng @TheLancet medicalxpress.com/news/2025-08-g…
In flight now & cant load link but more than 10 years ago my lab showed #Aldosterone increases intracellular sodium in cardiomyocytes #Eplerenone & #Spironolactone #MRA prevent apoptosis
Interaction Between #Aldosterone and #MRA #EPHESUS trial subset (n=453, mean age 62, 75% male) 📍Baseline aldosterone median: 5.6 ng/dL 📍Higher baseline aldosterone ↑ CV death/HF hosp risk in placebo (HR 1.04, p=0.002) but not eplerenone (p int=0.048) 📍Eplerenone ↑…
#تنبيه إن عاد هذا مريض ( لا قدر الله ) يشكو من #إسهال مائي حاد ( لأي سبب ) بعد استخدامه هذا الدواء ، يجب ايقاف الدواء فورا حتى يتوقف الاسهال خاصة في أمراض الفشل القلبي الـ #spironolactone يرفع البوتاسيوم ⬅البوتاسيوم يزيد الاسهال وايضاً قد يسبب ارتفاع البوتاسيوم توقف عضلة القلب
Spironolactone is a common treatment for acne in women but there has been a paucity of evidence from RCTs. This placebo-controlled trial showed that #spironolactone improved #acne, especially at week 24. bmj.com/content/381/bm…
#Spironolactone Use and Improved Outcomes in Patients With #HFpEF With Resistant #Hypertension #HeartFailure2023 @escardio
The effect of #spironolactone in pts with obesity at risk for HF: proteomic insights from the HOMAGE trial Spironolactone - 1st line for HTN in obesity with HF Spironolactone provides a similar ⤵️ in fibrosis markers in pts with and without obesity. onlinejcf.com/article/S1071-…
#CLEAR SYNERGY trial : Routine #Spironolactone in #AMI Spironolactone vs. placebo in 7062 post-MI patients (median follow-up: 3 years): 📍Primary outcomes: 📌CV death/new HF: 1.7 vs. 2.1 events/100 patient-years (HR 0.91, 95% CI 0.69–1.21, P=0.51) 📌MI, stroke, CV death/new HF:…
#Spironolactone vs #Amiloride for Resistant Hypertension A Randomized Clinical Trial N = 118 (1:1 randomization) 📍 12-week home #SBP ↓: • Amiloride: −13.6 mm Hg • Spironolactone: −14.7 mm Hg 📍 Between-group difference: −0.68 mm Hg (90% CI −3.50 to 2.14) ✅…
Dr. Jason M. Elinoff (pictured) et al. show that mineralocorticoid receptor antagonists improve ventricular interdependence in a rat PAH model, supporting use of #cardiacimaging in trials of #spironolactone in patients: ow.ly/7EcL50HX488 @NIHClinicalCntr @NIHCritCare
Clinical Pearl of the Day # 3 from @Lankenau Grand Rounds with @JJheart_doc : Here comes #Spironolactone!! @chrisdroogan @abaky_MD @RomanelliJean @docmrjaff @LloydKlein10 @MelissaRubin17 @RY_bread13 @DavidWienerMD @amankhaji12 @StevieBmd @iamritu
Ongoing #Spironolactone and #Finerenone trials #SPIRIT (DZHK) @dzhk_germany and #SPIRRIT (NIH) @NIH : Both trials including patients with #LVEF => 40% (and excluding patients with an #eGFR<30 ) #FINEARTS-HF #GTS2022 @ShelleyZieroth @markcpetrie20 @BiykemB #HeartFailure #MRA
For your weekend reading pleasure: A State of the Art Review from @AgarwalRajivMD et al on on-steroidal mineralocorticoid receptor antagonists #Finerenone #Spironolactone
#spironolactone a diuretic or disease-modifying 💊 in HFpEF? 📌prescribe it for 👥 with a TOPCAT America profile, prioritizing it over RAS blockers and potentially combine it with Sac/Val. 📌small ⬆️ in Cr, without signs of clinical deterioration, should never defer
#Spironolactone in Patients with an HFpEF Phenotype Suggestive of Cardiac Amyloidosis 📌In the substudy of #TOPCAT, patients with echo features of CA (IVS thickness: ≥1.2 cm ,S′ ≤6 cm/s) - had the worst prognosis 📌A similar benefit with spironolactone Tx compared to other Gp
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