A long day of travel ✈️🚉🚕 but got myself and my poster all the way to the UK for #GBD23! 🇬🇧 Excited to present at the first poster session on #spatialDLPFC !

lahuuki's tweet image. A long day of travel ✈️🚉🚕 but got myself and my poster all the way to the UK for #GBD23! 🇬🇧 Excited to present at the first poster session on #spatialDLPFC !

#spatialDLPFC increases ⏫ the #Visium sample size, and adds paired #snRNAseq 🎨🧪 We leverage data-driven clustering from #BayesSpace to define novel spatial domains. Also added #VisiumSPG to spatially map cell types 🗺️

lahuuki's tweet image. #spatialDLPFC increases ⏫ the #Visium sample size, and adds paired #snRNAseq 🎨🧪 We leverage data-driven clustering from #BayesSpace to define novel spatial domains. Also added #VisiumSPG to spatially map cell types 🗺️

Wow very proud to have won the poster award at #Connectome2024 ! 🏆 Thanks to everyone who stopped by to hear about spatial transcriptomics in the human brain 🧠 #spatialDLPFC

lahuuki's tweet image. Wow very proud to have won the poster award at #Connectome2024 ! 🏆 Thanks to everyone who stopped by to hear about spatial transcriptomics in the human brain 🧠 #spatialDLPFC

Poster prize, rewarding excellent poster design, explanation and discussion of results or methodology 🥇 @lahuuki for “A data-driven single cell and spatial transcriptomic map of the human prefrontal cortex”



Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…

New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

lahuuki's tweet image. New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


#BioC2023 Be sure to check out Nick Eagles' (github.com/Nick-Eagles) from @LieberInstitute talk on spot deconvolution benchmark + implementation in our #spatialDLPFC data at 10am 🔍

lahuuki's tweet image. #BioC2023 Be sure to check out Nick Eagles' (github.com/Nick-Eagles) from @LieberInstitute talk on spot deconvolution benchmark + implementation in our #spatialDLPFC data at 10am 🔍

¡Gracias Pilar @pilaralvjer & Cornelis @cornelisblauw for the invitation to present our work today at the 2023 NIA/LNG Neurodegenerative Diseases Seminar Series! 🛝 by @lahuuki: speakerdeck.com/lahuuki/2023-q… mine: speakerdeck.com/lcolladotor/20… #spatialDLPFC #Visium_SPG_AD @LieberInstitute

lcolladotor's tweet image. ¡Gracias Pilar @pilaralvjer & Cornelis @cornelisblauw for the invitation to present our work today at the 2023 NIA/LNG Neurodegenerative Diseases Seminar Series!

🛝 by @lahuuki: speakerdeck.com/lahuuki/2023-q…
mine: speakerdeck.com/lcolladotor/20…

#spatialDLPFC #Visium_SPG_AD @LieberInstitute

lcolladotor's tweet image. Expect some #spatialDLPFC tweetorials soon ;)

@biorxivpreprint #rstats @Bioconductor @10xGenomics

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex biorxiv.org/cgi/content/sh… #bioRxiv



I had so much fun generating the data, and of-course being part of this incredible team and #spatialDLPFC project. To read more about spot deconvolution, check out👇

Downstream analysis were powered up 🦸 with the paired datasets 🤝. Nick Eagles (github.com/Nick-Eagles) performed a spot deconvolution benchmark analysis between #tangram #Cell2location and #SPOTlight with the #VisiumSPG data

lahuuki's tweet image. Downstream analysis were powered up 🦸 with the paired datasets 🤝. Nick Eagles (github.com/Nick-Eagles) performed a spot deconvolution benchmark analysis between #tangram #Cell2location and #SPOTlight with the #VisiumSPG data


🚀 Motivating problem: In our #spatialDLPFC project, we identified colocalized genes and wanted to map them to spatial domains (cortex layers). 🤨Is it possible to visualize the two variables in a unified spatial map instead of two side-by-side plots?

BoyiGuo's tweet image. 🚀 Motivating problem:
In our #spatialDLPFC project, we identified colocalized genes and wanted to map them to spatial domains (cortex layers).
🤨Is it possible to visualize the two variables in a unified spatial map instead of two side-by-side plots?

Also leveraging the paired #snRNAseq and #Visium data @BoyiGuo & @mgrantpeters studied schizophrenia associated ligand-receptor pairs with spatial context in the DLPFC 🧠

lahuuki's tweet image. Also leveraging the paired #snRNAseq and #Visium data @BoyiGuo & @mgrantpeters studied schizophrenia associated ligand-receptor pairs with spatial context in the DLPFC 🧠


A huge thanks to all of the collaborators on the #spatialDLPFC project! Your expertise from the wet bench to the computational work made this work possible from @LieberInstitute, @jhubiostat, @ucl, and #PsychENCODE @NIMHgov 👨‍🔬🎉👩‍🔬


Looking for something fun on #FluorescenceFriday? Check out our #VisiumSPG data on samuibrowser.com to explore our spatially resolved human DLPFC transcriptomes! #spatialDLPFC @LieberInstitute

sanghokwon17's tweet image. Looking for something fun on #FluorescenceFriday? Check out our #VisiumSPG data on samuibrowser.com to explore our spatially resolved human DLPFC transcriptomes! #spatialDLPFC @LieberInstitute

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


I'm very excited that I was able to contribute to this amazing #spatialDLPFC study! We used #VistoSeg for generating cell counts which was used heavily for downstream analysis and spot deconvolution. doi.org/10.1101/2021.0…

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


Thanks for the chance to present about #spatialDLPFC 🧠😁! Checkout our pre-print on #snRNAseq & #visium data in the human brain: biorxiv.org/content/10.110…


Who would have thought there could be more *layers* of complexity to cortical annotation than what was first described by Santiago Ramon y Cajal in circa 1911? Very exciting work! #spatialDLPFC biorxiv.org/content/10.110…


Congrats Nick for successfully completing your 1st🥇 @LieberInstitute seminar 🙌🏽 Nick presented #spatialDLPFC spot deconvolution results @10xGenomics #snRNAseq #Visium #VisiumSPG 🛝 speakerdeck.com/nickeagles/lib… Interact with the data research.libd.org/spatialDLPFC/#… youtu.be/cCUHRdI4NSc

lcolladotor's tweet image. Congrats Nick for successfully completing your 1st🥇 @LieberInstitute seminar 🙌🏽

Nick presented #spatialDLPFC spot deconvolution results @10xGenomics #snRNAseq #Visium #VisiumSPG

🛝 speakerdeck.com/nickeagles/lib…

Interact with the data research.libd.org/spatialDLPFC/#…

youtu.be/cCUHRdI4NSc

Excited to share our latest spatial transcriptomics adventure generating a data-driven molecular atlas of the human DLPFC. Excellent tweetorial from @lahuuki below. Congrats to the #spatialDLPFC team and all collaborators who contributed.

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


🧠New pre-print from Louise A. Huuki-Myers et al - contributions from Mina and Melissa @PD_Progression and @PD_BrainMap #spatialDLPFC doi.org/10.1101/2023.0…


Wow very proud to have won the poster award at #Connectome2024 ! 🏆 Thanks to everyone who stopped by to hear about spatial transcriptomics in the human brain 🧠 #spatialDLPFC

lahuuki's tweet image. Wow very proud to have won the poster award at #Connectome2024 ! 🏆 Thanks to everyone who stopped by to hear about spatial transcriptomics in the human brain 🧠 #spatialDLPFC

Poster prize, rewarding excellent poster design, explanation and discussion of results or methodology 🥇 @lahuuki for “A data-driven single cell and spatial transcriptomic map of the human prefrontal cortex”



Thanks for the opportunity to share about #spatialDLPFC ! 🧠

Delighted to be hosting @lahuuki today for our own ‘lab meeting with friends’ at @CamNeuro and hearing of Single Cell and ST in the post mortem human brain

Pluchinolab's tweet image. Delighted to be hosting @lahuuki today for our own ‘lab meeting with friends’ at @CamNeuro and hearing of Single Cell and ST in the post mortem human brain
Pluchinolab's tweet image. Delighted to be hosting @lahuuki today for our own ‘lab meeting with friends’ at @CamNeuro and hearing of Single Cell and ST in the post mortem human brain


The original idea formed during the collab with @LieberInstitute on #spatialDLPFC project and expanded in ongoing study led by me and @sanghokwon17 from @martinowk lab for an even larger #SRT dataset studying neuropsychiatric disorders. #TeamScienceWins x.com/lahuuki/status…

New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

lahuuki's tweet image. New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…


New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

lahuuki's tweet image. New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


But actually come checkout my #spatialDLPFC poster this afternoon for even more #spatialLIBD content 😁 #BioC2023


#BioC2023 Be sure to check out Nick Eagles' (github.com/Nick-Eagles) from @LieberInstitute talk on spot deconvolution benchmark + implementation in our #spatialDLPFC data at 10am 🔍

lahuuki's tweet image. #BioC2023 Be sure to check out Nick Eagles' (github.com/Nick-Eagles) from @LieberInstitute talk on spot deconvolution benchmark + implementation in our #spatialDLPFC data at 10am 🔍

Looking forward to #BioC2023 ! @lcolladotor and I will be demoing the #spatialLIBD package 💻🔧 and I will be presenting new data and findings in my poster on #spatialDLPFC 🧠🧬 from our preprint 👩‍🔬 🔗doi.org/10.1101/2023.0…

**Speaker Spotlight** Louise Huuki-Myers Website: buff.ly/44gTkCz Twitter: @lahuuki Her #BioC2023 talk will be on Analyzing Spatially-Resolved Transcriptomics Data from Visium using spatialLIBD Registration for BioC2023: buff.ly/3nKEq72

Bioconductor's tweet image. **Speaker Spotlight**

Louise Huuki-Myers 

Website: buff.ly/44gTkCz 
Twitter: @lahuuki 

Her #BioC2023 talk will be on Analyzing Spatially-Resolved Transcriptomics Data from Visium using spatialLIBD 

Registration for BioC2023: buff.ly/3nKEq72


Congrats Nick for successfully completing your 1st🥇 @LieberInstitute seminar 🙌🏽 Nick presented #spatialDLPFC spot deconvolution results @10xGenomics #snRNAseq #Visium #VisiumSPG 🛝 speakerdeck.com/nickeagles/lib… Interact with the data research.libd.org/spatialDLPFC/#… youtu.be/cCUHRdI4NSc

lcolladotor's tweet image. Congrats Nick for successfully completing your 1st🥇 @LieberInstitute seminar 🙌🏽

Nick presented #spatialDLPFC spot deconvolution results @10xGenomics #snRNAseq #Visium #VisiumSPG

🛝 speakerdeck.com/nickeagles/lib…

Interact with the data research.libd.org/spatialDLPFC/#…

youtu.be/cCUHRdI4NSc

¡Gracias Pilar @pilaralvjer & Cornelis @cornelisblauw for the invitation to present our work today at the 2023 NIA/LNG Neurodegenerative Diseases Seminar Series! 🛝 by @lahuuki: speakerdeck.com/lahuuki/2023-q… mine: speakerdeck.com/lcolladotor/20… #spatialDLPFC #Visium_SPG_AD @LieberInstitute

lcolladotor's tweet image. ¡Gracias Pilar @pilaralvjer & Cornelis @cornelisblauw for the invitation to present our work today at the 2023 NIA/LNG Neurodegenerative Diseases Seminar Series!

🛝 by @lahuuki: speakerdeck.com/lahuuki/2023-q…
mine: speakerdeck.com/lcolladotor/20…

#spatialDLPFC #Visium_SPG_AD @LieberInstitute

For our last seminar 🇬🇧 trip, on Thursday May 25 @lahuuki & I will do a joint presentation on "Harnessing the power of spatially-resolved transcriptomics one step at a time" at @UCLIoN 9:30 am @LieberInstitute🧠 #spatialLIBD #spatialDLPFC #Visium_SPG_AD speakerdeck.com/lcolladotor/20…

lcolladotor's tweet image. For our last seminar 🇬🇧 trip, on Thursday May 25 @lahuuki & I will do a joint presentation on "Harnessing the power of spatially-resolved transcriptomics one step at a time" at @UCLIoN 9:30 am 

@LieberInstitute🧠
#spatialLIBD
#spatialDLPFC
#Visium_SPG_AD

speakerdeck.com/lcolladotor/20…

If you'll be at @TheCrick on Tuesday 5/23 & want to learn about 🧠 RNA-seq & spatial omics deconvolution with snRNA-seq, join us at 1pm! @LabGandhi @LieberInstitute 🛝 speakerdeck.com/lcolladotor/cr… #deconvochallenge -> #TREG #DeconvoBuddies #spatialLIBD -> #spatialDLPFC #Visium_SPG_AD

lcolladotor's tweet image. If you'll be at @TheCrick on Tuesday 5/23 & want to learn about 🧠 RNA-seq & spatial omics deconvolution with snRNA-seq, join us at 1pm! @LabGandhi @LieberInstitute
🛝 speakerdeck.com/lcolladotor/cr…

#deconvochallenge -> #TREG #DeconvoBuddies
#spatialLIBD -> #spatialDLPFC #Visium_SPG_AD


Thanks to #GBD23 @lahuuki & I can finally meet in person with our #spatialDLPFC collaborators @mgrantpeters @MinaRyten (not her account or is it?🤔) + celebrate our @biorxivpreprint 📜 with them ^^ Congrats Mina on your new job! 🎉 📸: @pilaralvjer thx!

lcolladotor's tweet image. Thanks to #GBD23 @lahuuki & I can finally meet in person with our #spatialDLPFC collaborators @mgrantpeters @MinaRyten (not her account or is it?🤔) + celebrate our @biorxivpreprint 📜 with them ^^

Congrats Mina on your new job! 🎉

📸: @pilaralvjer thx!

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


A long day of travel ✈️🚉🚕 but got myself and my poster all the way to the UK for #GBD23! 🇬🇧 Excited to present at the first poster session on #spatialDLPFC !

lahuuki's tweet image. A long day of travel ✈️🚉🚕 but got myself and my poster all the way to the UK for #GBD23! 🇬🇧 Excited to present at the first poster session on #spatialDLPFC !

#Visium_SPG_AD with @sowmyapartybun benefited from simultaneous updates to #spatialLIBD that were also needed for #spatialDLPFC by @lahuuki @abspangler Nick-Eagles et al It wouldn't have been possible without #VistoSeg v2 by @MadhaviTippani + a whole village, thanks everyone!!


🚀 Motivating problem: In our #spatialDLPFC project, we identified colocalized genes and wanted to map them to spatial domains (cortex layers). 🤨Is it possible to visualize the two variables in a unified spatial map instead of two side-by-side plots?

BoyiGuo's tweet image. 🚀 Motivating problem:
In our #spatialDLPFC project, we identified colocalized genes and wanted to map them to spatial domains (cortex layers).
🤨Is it possible to visualize the two variables in a unified spatial map instead of two side-by-side plots?

Also leveraging the paired #snRNAseq and #Visium data @BoyiGuo & @mgrantpeters studied schizophrenia associated ligand-receptor pairs with spatial context in the DLPFC 🧠

lahuuki's tweet image. Also leveraging the paired #snRNAseq and #Visium data @BoyiGuo & @mgrantpeters studied schizophrenia associated ligand-receptor pairs with spatial context in the DLPFC 🧠


I'm very excited that I was able to contribute to this amazing #spatialDLPFC study! We used #VistoSeg for generating cell counts which was used heavily for downstream analysis and spot deconvolution. doi.org/10.1101/2021.0…

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


Full history + archive on @ZENODO_ORG the preprint version & published one See github.com/LieberInstitut… by @lahuuki @abspangler me, et al #spatialDLPFC Full history allows you to see contributions from everyone too. Including early exploratory work like what @artaseyedian did


لا توجد نتائج لـ "#spatialdlpfc"

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…

A long day of travel ✈️🚉🚕 but got myself and my poster all the way to the UK for #GBD23! 🇬🇧 Excited to present at the first poster session on #spatialDLPFC !

lahuuki's tweet image. A long day of travel ✈️🚉🚕 but got myself and my poster all the way to the UK for #GBD23! 🇬🇧 Excited to present at the first poster session on #spatialDLPFC !

¡Gracias Pilar @pilaralvjer & Cornelis @cornelisblauw for the invitation to present our work today at the 2023 NIA/LNG Neurodegenerative Diseases Seminar Series! 🛝 by @lahuuki: speakerdeck.com/lahuuki/2023-q… mine: speakerdeck.com/lcolladotor/20… #spatialDLPFC #Visium_SPG_AD @LieberInstitute

lcolladotor's tweet image. ¡Gracias Pilar @pilaralvjer & Cornelis @cornelisblauw for the invitation to present our work today at the 2023 NIA/LNG Neurodegenerative Diseases Seminar Series!

🛝 by @lahuuki: speakerdeck.com/lahuuki/2023-q…
mine: speakerdeck.com/lcolladotor/20…

#spatialDLPFC #Visium_SPG_AD @LieberInstitute

New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

lahuuki's tweet image. New in @sciencemagazine: our work from @LieberInstitute #spatialDLPFC applies #snRNAseq and #Visium spatial transcriptomic in the DLPFC to better understand anatomical structure and cellular populations in the human brain #PsychENCODE doi.org/10.1126/scienc…

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


lcolladotor's tweet image. Expect some #spatialDLPFC tweetorials soon ;)

@biorxivpreprint #rstats @Bioconductor @10xGenomics

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex biorxiv.org/cgi/content/sh… #bioRxiv



#BioC2023 Be sure to check out Nick Eagles' (github.com/Nick-Eagles) from @LieberInstitute talk on spot deconvolution benchmark + implementation in our #spatialDLPFC data at 10am 🔍

lahuuki's tweet image. #BioC2023 Be sure to check out Nick Eagles' (github.com/Nick-Eagles) from @LieberInstitute talk on spot deconvolution benchmark + implementation in our #spatialDLPFC data at 10am 🔍

#spatialDLPFC increases ⏫ the #Visium sample size, and adds paired #snRNAseq 🎨🧪 We leverage data-driven clustering from #BayesSpace to define novel spatial domains. Also added #VisiumSPG to spatially map cell types 🗺️

lahuuki's tweet image. #spatialDLPFC increases ⏫ the #Visium sample size, and adds paired #snRNAseq 🎨🧪 We leverage data-driven clustering from #BayesSpace to define novel spatial domains. Also added #VisiumSPG to spatially map cell types 🗺️

Wow very proud to have won the poster award at #Connectome2024 ! 🏆 Thanks to everyone who stopped by to hear about spatial transcriptomics in the human brain 🧠 #spatialDLPFC

lahuuki's tweet image. Wow very proud to have won the poster award at #Connectome2024 ! 🏆 Thanks to everyone who stopped by to hear about spatial transcriptomics in the human brain 🧠 #spatialDLPFC

Poster prize, rewarding excellent poster design, explanation and discussion of results or methodology 🥇 @lahuuki for “A data-driven single cell and spatial transcriptomic map of the human prefrontal cortex”



Thanks to #GBD23 @lahuuki & I can finally meet in person with our #spatialDLPFC collaborators @mgrantpeters @MinaRyten (not her account or is it?🤔) + celebrate our @biorxivpreprint 📜 with them ^^ Congrats Mina on your new job! 🎉 📸: @pilaralvjer thx!

lcolladotor's tweet image. Thanks to #GBD23 @lahuuki & I can finally meet in person with our #spatialDLPFC collaborators @mgrantpeters @MinaRyten (not her account or is it?🤔) + celebrate our @biorxivpreprint 📜 with them ^^

Congrats Mina on your new job! 🎉

📸: @pilaralvjer thx!

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


Congrats Nick for successfully completing your 1st🥇 @LieberInstitute seminar 🙌🏽 Nick presented #spatialDLPFC spot deconvolution results @10xGenomics #snRNAseq #Visium #VisiumSPG 🛝 speakerdeck.com/nickeagles/lib… Interact with the data research.libd.org/spatialDLPFC/#… youtu.be/cCUHRdI4NSc

lcolladotor's tweet image. Congrats Nick for successfully completing your 1st🥇 @LieberInstitute seminar 🙌🏽

Nick presented #spatialDLPFC spot deconvolution results @10xGenomics #snRNAseq #Visium #VisiumSPG

🛝 speakerdeck.com/nickeagles/lib…

Interact with the data research.libd.org/spatialDLPFC/#…

youtu.be/cCUHRdI4NSc

For our last seminar 🇬🇧 trip, on Thursday May 25 @lahuuki & I will do a joint presentation on "Harnessing the power of spatially-resolved transcriptomics one step at a time" at @UCLIoN 9:30 am @LieberInstitute🧠 #spatialLIBD #spatialDLPFC #Visium_SPG_AD speakerdeck.com/lcolladotor/20…

lcolladotor's tweet image. For our last seminar 🇬🇧 trip, on Thursday May 25 @lahuuki & I will do a joint presentation on "Harnessing the power of spatially-resolved transcriptomics one step at a time" at @UCLIoN 9:30 am 

@LieberInstitute🧠
#spatialLIBD
#spatialDLPFC
#Visium_SPG_AD

speakerdeck.com/lcolladotor/20…

If you'll be at @TheCrick on Tuesday 5/23 & want to learn about 🧠 RNA-seq & spatial omics deconvolution with snRNA-seq, join us at 1pm! @LabGandhi @LieberInstitute 🛝 speakerdeck.com/lcolladotor/cr… #deconvochallenge -> #TREG #DeconvoBuddies #spatialLIBD -> #spatialDLPFC #Visium_SPG_AD

lcolladotor's tweet image. If you'll be at @TheCrick on Tuesday 5/23 & want to learn about 🧠 RNA-seq & spatial omics deconvolution with snRNA-seq, join us at 1pm! @LabGandhi @LieberInstitute
🛝 speakerdeck.com/lcolladotor/cr…

#deconvochallenge -> #TREG #DeconvoBuddies
#spatialLIBD -> #spatialDLPFC #Visium_SPG_AD


Looking for something fun on #FluorescenceFriday? Check out our #VisiumSPG data on samuibrowser.com to explore our spatially resolved human DLPFC transcriptomes! #spatialDLPFC @LieberInstitute

sanghokwon17's tweet image. Looking for something fun on #FluorescenceFriday? Check out our #VisiumSPG data on samuibrowser.com to explore our spatially resolved human DLPFC transcriptomes! #spatialDLPFC @LieberInstitute

Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠 @LieberInstitute @10xGenomics #scitwitter 📰 doi.org/10.1101/2023.0…

lahuuki's tweet image. Hot of the pre-print press! 🔥 Our latest work #spatialDLPFC pairs #snRNAseq and #Visium spatial transcriptomic data in the human #DLPFC building a neuroanatomical atlas of this critical brain region 🧠
@LieberInstitute @10xGenomics #scitwitter
📰 doi.org/10.1101/2023.0…


I had so much fun generating the data, and of-course being part of this incredible team and #spatialDLPFC project. To read more about spot deconvolution, check out👇

Downstream analysis were powered up 🦸 with the paired datasets 🤝. Nick Eagles (github.com/Nick-Eagles) performed a spot deconvolution benchmark analysis between #tangram #Cell2location and #SPOTlight with the #VisiumSPG data

lahuuki's tweet image. Downstream analysis were powered up 🦸 with the paired datasets 🤝. Nick Eagles (github.com/Nick-Eagles) performed a spot deconvolution benchmark analysis between #tangram #Cell2location and #SPOTlight with the #VisiumSPG data


🚀 Motivating problem: In our #spatialDLPFC project, we identified colocalized genes and wanted to map them to spatial domains (cortex layers). 🤨Is it possible to visualize the two variables in a unified spatial map instead of two side-by-side plots?

BoyiGuo's tweet image. 🚀 Motivating problem:
In our #spatialDLPFC project, we identified colocalized genes and wanted to map them to spatial domains (cortex layers).
🤨Is it possible to visualize the two variables in a unified spatial map instead of two side-by-side plots?

Also leveraging the paired #snRNAseq and #Visium data @BoyiGuo & @mgrantpeters studied schizophrenia associated ligand-receptor pairs with spatial context in the DLPFC 🧠

lahuuki's tweet image. Also leveraging the paired #snRNAseq and #Visium data @BoyiGuo & @mgrantpeters studied schizophrenia associated ligand-receptor pairs with spatial context in the DLPFC 🧠


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