AdamSharpMedOnc's profile picture. Academic medical oncologist. Interested in biology, prostate cancer and drug development. Husband/Dad/Sport. Views my own and no specific advice/DMs.

Adam Sharp

@AdamSharpMedOnc

Academic medical oncologist. Interested in biology, prostate cancer and drug development. Husband/Dad/Sport. Views my own and no specific advice/DMs.

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The delta seems to be diminishing. I tried once and it pulled me back in. You know where to find me if you need me. Keep up the good work 🥰.

AdamSharpMedOnc's tweet image. The delta seems to be diminishing. I tried once and it pulled me back in. You know where to find me if you need me. Keep up the good work 🥰.

Adam Sharp heeft deze post opnieuw geplaatst

My co-authors and I report this week in @JCI_insight a pre-specified secondary analysis of the CARD trial, to establish the prognostic and predictive capacity of this assay. insight.jci.org/articles/view/… @AdamSharpMedOnc @BertrandTOMBAL

OssianLongoria's tweet image. My co-authors and I report this week in @JCI_insight a pre-specified secondary analysis of the CARD trial, to establish the prognostic and predictive capacity of this assay.

insight.jci.org/articles/view/…

@AdamSharpMedOnc @BertrandTOMBAL

Will be at AACR Prostate and GU ASCO for those interested in a catch up. Can message as profile still active. 🥰

The delta seems to be diminishing. I tried once and it pulled me back in. You know where to find me if you need me. Keep up the good work 🥰.

AdamSharpMedOnc's tweet image. The delta seems to be diminishing. I tried once and it pulled me back in. You know where to find me if you need me. Keep up the good work 🥰.


Adam Sharp heeft deze post opnieuw geplaatst

I recently read that clinicians with the highest empathy levels & patient satisfaction scores are at a higher risk of burnout. They often feel immense pressure to provide care that is beyond their human limits (both physically and emotionally). That hit hard.


Adam Sharp heeft deze post opnieuw geplaatst

Truly honored to receive a PCF Challenge Award with Drs. Isaac Kim, Sidi Chen, and Adam Sharp. Excited to see how our AI-driven efforts can contribute to precision medicine in prostate cancer.@PCFnews @Yale_Urology @Yale @YaleMed @YaleCancer @AdamSharpMedOnc


Adam Sharp heeft deze post opnieuw geplaatst

Warms the heart to see Dr. Sharp convert to a Major League Baseball fan!


Attention turns to this evening 🔱

Finish the fight. #SeizeTheMoment

Mariners's tweet image. Finish the fight. #SeizeTheMoment


Kudos to @AzadOncology. Summary slide is a take home for all. Another important active therapy - the slam dunk we all hoped - may be less so. Lots to unpick.

Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…

montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…
montypal's tweet image. Congrats to @DrScottTagawa on his presentation of PSMA-Addition, and to @AzadOncology on a very thoughtful discussion. Compelling data data but agree with Azad’s take that questions remain. Excellent points around the possibility of a “sink effect” & risks of secondary…


This is very very sad. We must do better. Congratulations @LouiseKostos and very sorry this happened.

@myESMO #ESMO25 ⭐ PhD @LouiseKostos flew 24 hrs with her 3 month old baby from Melbourne to Berlin to present #AlphaBet co-published in @TheLancetOncol ... Denied entry to conference - under 18s not allowed including babies! Thoughts?

DrMHofman's tweet image. @myESMO #ESMO25 ⭐ PhD @LouiseKostos flew 24 hrs with her 3 month old baby from Melbourne to Berlin to present #AlphaBet co-published in @TheLancetOncol ... Denied entry to conference - under 18s not allowed including babies! Thoughts?
DrMHofman's tweet image. @myESMO #ESMO25 ⭐ PhD @LouiseKostos flew 24 hrs with her 3 month old baby from Melbourne to Berlin to present #AlphaBet co-published in @TheLancetOncol ... Denied entry to conference - under 18s not allowed including babies! Thoughts?


And sometimes we also image the target which may in itself have implications. Such exciting times, so much to unpick. We keep pushing 😊. nature.com/articles/s4158…

So important. Most targets are dynamic. Also important consequences for sequencing therapies targeting the same target.



Challenge is (as almost always) the imperfect biomarker. Bland and open to pre-analytical variables. I’m sure a true measure of pathway functionality would push that needle further 😊.

Capitello-281 evaluated Akt inhibitor in PTEN deficient mHSPC. 6000 pts screened to randomize ~ 1K. Modest rPFS benefit, OS immature. Nice to see biomarker approach, TBD if it moves the needle enough to justify the toxicity and identification

OncHahn's tweet image. Capitello-281 evaluated Akt inhibitor in PTEN deficient mHSPC. 6000 pts screened to randomize ~ 1K. Modest rPFS benefit, OS immature. Nice to see biomarker approach, TBD if it moves the needle enough to justify the toxicity and identification
OncHahn's tweet image. Capitello-281 evaluated Akt inhibitor in PTEN deficient mHSPC. 6000 pts screened to randomize ~ 1K. Modest rPFS benefit, OS immature. Nice to see biomarker approach, TBD if it moves the needle enough to justify the toxicity and identification
OncHahn's tweet image. Capitello-281 evaluated Akt inhibitor in PTEN deficient mHSPC. 6000 pts screened to randomize ~ 1K. Modest rPFS benefit, OS immature. Nice to see biomarker approach, TBD if it moves the needle enough to justify the toxicity and identification
OncHahn's tweet image. Capitello-281 evaluated Akt inhibitor in PTEN deficient mHSPC. 6000 pts screened to randomize ~ 1K. Modest rPFS benefit, OS immature. Nice to see biomarker approach, TBD if it moves the needle enough to justify the toxicity and identification


So important. Most targets are dynamic. Also important consequences for sequencing therapies targeting the same target.

We investigated KLK2 expression in PC and demonstrated lower expression in liver, post ADT and ARPI, and in CRPC setting. Strategies to define placement of treatment in the future. #ESMO25@myESMO⁩ ⁦@OncoAlert

DrRanaMcKay's tweet image. We investigated KLK2 expression in PC and demonstrated lower expression in liver, post ADT and ARPI, and in CRPC setting. Strategies to define placement of treatment in the future. #ESMO25 ⁦@myESMO⁩ ⁦@OncoAlert⁩


My biggest challenge today!

AdamSharpMedOnc's tweet image. My biggest challenge today!

Adam Sharp heeft deze post opnieuw geplaatst

I joke that I have 3 “expensive hobbies”: golf, wine, and academic anesthesia. I’m lucky that I don’t have to publish or win grants to feed my family but the rejections still hurt. Thank you to @AdamSharpMedOnc for this post - we often see success on X but rarely witness failure

3 rejections this week. It’s part of the world that we live in and I am at peace with that. The struggle is the many evening and weekend hours that went into them which were not spent with wife and (rapidly growing) kids - this is less easy to forgive. Look after those closest 🥰



You took the picture! #notanexclusion

AdamSharpMedOnc's tweet image. You took the picture! #notanexclusion
AdamSharpMedOnc's tweet image. You took the picture! #notanexclusion
AdamSharpMedOnc's tweet image. You took the picture! #notanexclusion
AdamSharpMedOnc's tweet image. You took the picture! #notanexclusion

For those out there with less gray hair than me… Never underestimate the value in working with good people towards a common goal. You can always do more together Sometimes academia makes us forget that science is a team sport & no one does anything alone #ESMO25 @myESMO



Run and covering the unit 🥰

AdamSharpMedOnc's tweet image. Run and covering the unit 🥰

Great to see the room packed and to hear the excited buzz ahead of the ‘optimising outcomes in advanced prostate cancer’ 🩵 #ESMO25 @AttardLab



Adam Sharp heeft deze post opnieuw geplaatst

I am sorry - I recently got rejected it does sting but sometimes a rejection yields resilience. I once followed the guidance , and got my paper into a stronger journal - keep up the good work


Adam Sharp heeft deze post opnieuw geplaatst

💯 Agree. 🙋🏽‍♀️Grant rejections or significant rewrites are part of the process but also 💔heartbreaking not only for the investigator’s ego but the countless hours, nights & weekends not spent w family (and not reimbursed by institutions) #MedTwitter

3 rejections this week. It’s part of the world that we live in and I am at peace with that. The struggle is the many evening and weekend hours that went into them which were not spent with wife and (rapidly growing) kids - this is less easy to forgive. Look after those closest 🥰



Adam Sharp heeft deze post opnieuw geplaatst

And take a moment to enjoy this huge success which is superb science that may lead to new novel treatments. Impressive stuff! nature.com/articles/s4146…


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