Andy Stringer
@AndyStringer
Not everything that can be counted counts. Not everything that counts can be counted. (WB Cameron, 1963) Now only on @andystringer.bsky.social
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The European march before we vote for our national liberation. 🇬🇪🇪🇺 Tbilisi, Georgia. October 20, 2024 #GeVote2024 📷 Giorgi Ebanoidze
Nerve injury causes sustained upregulation of α2δ-1 in the DRG, contributing to pain hypersensitivity by directly interacting with and augmenting presynaptic NMDA receptor activity in the spinal dorsal horn. #gabapentanoids #CK2 #HDAC2 #pain jbc.org/article/S0021-…
jbc.org
Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone...
The development of chronic neuropathic pain involves complex synaptic and epigenetic mechanisms. Nerve injury causes sustained upregulation of α2δ-1 (encoded by the Cacna2d1 gene) in the dorsal root...
Seldom if ever seen so many EU flags at #LastNightOfTheProms. Anyone would think the country is genuinely sick to death of Brexit.
Our latest review article explores how SUMOylation & deSUMOylation might hold the key to understanding pain, one ion channel at a time. ✨ Imagine tiny molecular tweaks making a world of difference in chronic pain. 🔍 #SUMOylation #PainResearch link.springer.com/10.1007/s12035…
Wow! I learn something truly fascinating, and often unexpected, every day. Nice use of gold nano-particles.
HOWZAT!!!! Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system | Science Advances science.org/doi/10.1126/sc…
Happy 200th birthday to Anton Bruckner! 🎶🎵🎼🎻 It was a real treat to listen to the Cleveland Orchestra rehearse the 4th symphony outdoors. The concert is tonight but tickets sold out faster than an Oasis concert!
Excellent article on targeting Nav1.8 in @AmSciMag by @mvbroadfoot scientificamerican.com/article/new-pa… Thanks for highlighting @regulonix's and @KhannaLabUF differentiated strategy on Nav1.7.
Great music tonight from Jaroslav Šindler Quartet at Jazz Dock in Prague.
Nothing to see here, just the guy who bought Twitter having free speech explained to him by a cat
Interesting approach with fentanyl derivative RO-76: "targeting water molecules in the sodium binding pocket may be an avenue to modulate signaling properties of opioids, and which may potentially be extended to other GPCRs" #Pain pubs.acs.org/doi/10.1021/ac… pubs.acs.org/doi/10.1021/ac…
pubs.acs.org
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR
The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse effects, such as respiratory depression and physical dependence, necessitate the development of alternative...
Here is the final version of @KhannaLabUF's latest paper: Small molecule targeting NaV1.7 via inhibition of... : PAIN journals.lww.com/pain/abstract/…
Sir Lindsay Hoyle, gave us new MPs such a warm welcome at Speaker’s House. His late father, Doug, represented the Nelson & Colne constituency 1974-79, and his father’s first run was actually for Clitheroe in 1964, during which Lindsay delivered leaflets, aged seven!
We're looking forward to great things from local lad Jonathan 👍
Officially sworn in 📖 I will be an outspoken champion for Pendle & Clitheroe in Parliament.
There’s a clear message for Europe here… Aping or appeasing the far-right only sucks you into them. You have to take it on, putting your own true principles out there in stark opposition to it. It a message for the Tories, for Labour (on immigration & Brexit) and all Europe.
This is an incredible piece of work by @JonathanPieNews. From the research, to the sequencing, to the performance. You want to know why so many people are turning away from vapid MSM and looking to political comedy & alternative news? Look no further. 👇
Here's the person to vote for if you want change for the better in Pendle & Clitheroe. 👍
The polls show it is too close to call between Labour and the Conservatives in Pendle & Clitheroe. No other party is even close here. The choice could not be clearer: more decline under the Conservatives, or change with Labour.
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