
BryanRoth
@zenbrainest
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
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Congrats to the team: especially @gori7873 and Brian Krumm from @RothLabUNC and Adrien and Matan from Greg Scherrer's lab!! A ton of work! Structure-guided design of a peripherally restricted chemogenetic system: Cell cell.com/cell/fulltext/…
Oh yes, although most I knew about jumped rather than having to be pushed. Ranking was of the leader, since he/she held the responsibility. The other two were usually a postdoc and a technician. Postdoc appts were only two years anyway (contrast that to today!), and they were…
Were there instances of group leaders being canned for being in the bottom 10% for consecutive years? And, if so, what happened to their team (which I suppose was partially responsible for the low ranking? Or was the ranking solely a measure of the individual leader?)
“The problem was not the molecule —it was the wrong target!”
I served for years on the Scientific Advisory Board of Novartis. Its CSO Mark Fishman once told me something that changed my life: "Nowadays we can make drugs against any molecule. But for neurodegeneration, we don't know what to target". That's what I've been doing ever since.
The @NIH has awarded a $14.2M Director’s Transformative Research Award to Nobel Prize-winning neuroscientist Ardem Patapoutian (@ardemp), Professor Li Ye (@liye_tsri) and Associate Professor Xin Jin (@xinjin) to map the neural circuits underlying interoception—how the nervous…

BREAKING NEWS The Norwegian Nobel Committee has decided to award the 2025 #NobelPeacePrize to Maria Corina Machado for her tireless work promoting democratic rights for the people of Venezuela and for her struggle to achieve a just and peaceful transition from dictatorship to…

Great Job - Great Colleagues - Great Science👍 Help us pick the next generation of @HHMINEWS Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows Relocation to DC is required, perfect for academic PIs looking for their next chapter…
Psychedelics Activate 5-HT2A Neurons in Prefrontal Cortex #psychedelics scienmag.com/psychedelics-a…
scienmag.com
Psychedelics Activate 5-HT2A Neurons in Prefrontal Cortex
In a groundbreaking study poised to reshape our understanding of psychedelic pharmacology and its neural substrates, a team of scientists has elucidated the precise cellular mechanisms by which...
Online now: Synaptic priming: A framework for pharmacotherapy in depression dlvr.it/TNYR1R

A parabrachial hub for need-state control of enduring pain nature.com/articles/s4158…
nature.com
A parabrachial hub for need-state control of enduring pain
Nature - Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

In a rat hippocampal seizure model, Wang et al. find that parvalbumin-positive interneurons have an essential role in seizure onset, whereas somatostatin-positive interneurons appear to be important in seizure termination. tinyurl.com/3ntebf4a

Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation | Translational Psychiatry nature.com/articles/s4139…
nature.com
Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through...
Translational Psychiatry - Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation
Biliverdin reductase A is a major determinant of protective NRF2 signaling | PNAS pnas.org/doi/10.1073/pn…
Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve–neutrophil axis nature.com/articles/s4146…
nature.com
Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve–neutrophil axis
Nature Communications - Acute lung injury (ALI) carries high mortality with limited treatment. Here, the authors show in mice a brain-lung circuit wherein CRH neurons activation in the...
The @UNC_Biology Biology Department is searching for a tenure-track Assistant Professor in Plant Molecular Biology. Chapel Hill is a wonderful place and Biology is an amazing group of people. To apply, see: unc.peopleadmin.com/postings/307414

From this morning’s chat between Brunkow and a Nobel cmte member: she noted that mapping the mouse mutation (which was heroic: brute force, high risk) would be easy today; and the real discovery was the molecular slog that followed. Many such discoveries remain to be made.
5-HT2B and cancer? pubmed.ncbi.nlm.nih.gov/41034989/
pubmed.ncbi.nlm.nih.gov
The aggressive colorectal cancer subtype marker HTR2B has a dual role depending on the tumor...
Colorectal cancer (CRC) is the second-third most frequent cancer type in the Western countries, with significant inter- and intra-patient cellular heterogeneity. The transcriptomics-based CRC...
Desensitization of opsin responses during all-optical interrogation depends on imaging parameters biorxiv.org/content/10.110… #biorxiv_neursci
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