Bashor Lab
@BashorLab
Bashor Lab in Houston, Texas | Mammalian Synthetic Biology et al.
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🚨NEW PUBLICATION ALERT🚨: In a paper out today in @ScienceMagazine we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/sc…. 🧵1/n
PhDone! I am pleased to announce that I have finished my PhD in Bioengineering from Rice University co-advised by @BashorLab and @OlsonCell. We tackled some pretty difficult problems bridging cell therapy and synthetic biology.
Delighted to share the final version of this paper out now! I led this project with @amparo_cosio during my PhD in @TheLeonardLab to investigate how we could program smart cell therapies to sense and respond to markers of disease—taking inspiration from natural human receptors!
How can we combine the exquisite function of natural receptors with the programmability of synthetic biology? Check out this exciting new story led by @HaileyEdelstein and @amparo_cosio out today in @nchembio
Years ago, we set out to create synbio tech to solve a major challenge: generating precision antibodies for challenging membrane proteins. It's a DREAM COME TRUE to report we've now launched K2 Therapeutics (k2-tx.com) to advance this into transformative medicines
Excited to share our @Nature papers exploiting the receptor pairing code to expand the cytokine receptor alphabet in T cells. Nonnatual receptors reprograms T cells into myeloid lineage. Grateful for the amazing collaborators @xrtcell , @MasatoOgishi
Genome-wide chromatin recording resolves dynamic cell state changes | from Prof. Michael Elowitz's lab @ElowitzLab biorxiv.org/content/10.110…
Biological foundation models have hit a plateau. Scaling isn't working as expected. Foundational concepts from evolutionary biology could have predicted this: 🧵 research.arcadiascience.com/pub/idea-phylo… [1/9]
How do chromatin remodelers use #IDRs to find their TF binding partners? Check out San’s tweetorial about SWI/SNF (cBAF) subunit ARID1A and β-catenin, now online at Mol Cell
Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…
Have you always wanted to take a protein from its native context and make it work elsewhere? Our novel sampler computationally “cytosolize” a secreted enzyme while maintaining its structure, generalizable to other multi-objective guided generation tasks biorxiv.org/content/10.110…
Online now @ Cell is the yeast multicellular engineering paper from @DrFankangMeng - the fruits of his productive PhD. He developed modular synthetic biology tools to bring multicellular behaviours to yeast - adhesion, juxtacrine signalling and more. cell.com/cell/fulltext/…
Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…
How do we improve nanoparticle delivery to tumors? Please see our recent publication detailing a dual pH-responsive micelle with improved tumor biodistribution. We engineer a STING-activating micelle (PC7A) using a carrier polymer strategy for immunoRx pubs.acs.org/doi/10.1021/ja…
🚨 New Preprint 🚨 A continuous landscape of signaling encodes a corresponding landscape of CAR T cell phenotype How can we tune JAK/STAT signaling to create better immune cell therapies? doi.org/10.1101/2025.0…
This is your last chance to showcase your work at this year's mSBW. The program offers a unique platform to share your latest research and connect with experts. Submit your abstract for a poster presentation today — Limited spaces left! bit.ly/3WwfChK #mSBW2025 #research
🚨 Our lab just rewrote life‘s operating system! Together, we’ve built Syn57 - an E. coli with a synthetic genome running on a 57-codon genetic code! biorxiv.org/content/10.110… #SyntheticBiology #Syn57 #PhD #GeneticCode #GenomeEngineering #Biosecurity #FutureOfBiology
Thrilled to share our preprint led by @chenxinyi924 on programmable molecule delivery via engineered trogocytosis called TRANSFER! a 🧵 @Stanford_ChEMH @bioe_stanford
Happy Sunday to all! This morning, we are excited to share Chase’s work developing a simple, scalable method to assemble 100s-1000s of custom genes from oligo pools using standard lab tools! (Small 🧵 below)
Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo go.nature.com/4kFUnEO
Unlike a lot of other universities right now, we are still hiring for new faculty here at Imperial in London 🎉🚨🇬🇧🫖 If you want to come and run a research group in the theme of bioengineering then apply to be my colleague before the end of April. imperial.ac.uk/jobs/search-jo…
Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics? @HWaymentSteele and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1! 🧵
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