Cell Stem Cell
@CellStemCell
A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
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Bioprinted platform for parallelized screening of engineered microtissues in vivo hubs.li/Q03Szjq90 Article highlight from Cell Stem Cell
Read a joint collection from @CellStemCell and @stemcellreports (@ISSCR) on organs-on-a-chip systems which as research advances promise to transform biomedical science and improve therapeutic outcomes. hubs.li/Q03Szhvb0 @GairdnerAwards @SickKidsNews
Online Now! Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages dlvr.it/TPBGdz #stemcells
cell.com
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal...
Zeng and colleagues identify Clu+ cardiomyocytes as key regenerative drivers that orchestrate a cardio-immune circuit to resolve inflammation and promote CM proliferation, highlighting CLU as a...
Boosting dopamine: Following the lineage toward Parkinson’s repair dlvr.it/TP82Jx
cell.com
Boosting dopamine: Following the lineage toward Parkinson’s repair
Low yields of dopamine neurons in human stem cell-derived neural grafts limit their potential for treating Parkinson’s disease. Zhang et al. develop a new three-dimensional differentiation method,...
RPE replacement therapy for dry AMD—early success in a phase 1/2 clinical trial dlvr.it/TP7xjt
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis dlvr.it/TP7tGQ
N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells dlvr.it/TP7hxY
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling dlvr.it/TP6vHd
cell.com
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease...
O’Hern et al. present a novel human heart-macrophage assembloid platform generated by integrating hPSC-derived embryonic monocytes into heart organoids. These tissue-resident macrophages regulate...
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson’s disease cell therapy dlvr.it/TP6rs2
EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming dlvr.it/TP6p5y
Vitamin C conveys geroprotection on primate ovaries dlvr.it/TP6mbN
cell.com
Vitamin C conveys geroprotection on primate ovaries
Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles....
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula models dlvr.it/TP6kS6
cell.com
Crosstalk between tissue mechanics and BMP4 signaling regulates symmetry breaking in human gastrula...
Brivanlou and colleagues used optogenetics to spatially control BMP4 expression in human stem cell models across different mechanical regimes. By combining these experiments with mathematical...
Hypoxia promotes airway differentiation in the human lung epithelium dlvr.it/TP6gN7
cell.com
Hypoxia promotes airway differentiation in the human lung epithelium
Dong and colleagues uncover low oxygen-directed differentiation of human lung progenitors to airway rather than alveolar fate and show how the process is controlled by hypoxia-inducible factors....
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential dlvr.it/TP6b2F
cell.com
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates...
(Cell Stem Cell 29, 1669–1684.e1–e6; December 1, 2022)
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular degeneration: Low-dose clinical outcomes dlvr.it/TP6XT4
cell.com
Safety and tolerability of RPESC-RPE transplantation in patients with dry age-related macular...
Retinal pigment epithelium (RPE) cell loss in dry age-related macular degeneration leads to progressive vision decline. Stern and others implanted adult RPE stem cell-derived RPE progeny at a 4-week...
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L96tu0Ctj…
Thrilled to share our new paper in @CellStemCell! We present a brain organoid atlas for NDDs, integrating hBO phenotypes, transcriptomics, WES, and brain imaging. We hope this resource inspires new studies and therapies for NDDs!
Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. authors.elsevier.com/a/1m2L96tu0Ctj…
Online Now! A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders dlvr.it/TP3CkX #stemcells
cell.com
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders
Wang and colleagues present a phenotypic brain organoid atlas for neurodevelopmental disorders, revealing disease-specific cellular and molecular alterations that illuminate NDD pathogenesis....
Online Now! Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity dlvr.it/TP385S #stemcells
cell.com
Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and...
The tumor stroma contains heterogenous cell types with senescent phenotypes. Lee et al. characterize a cancer-associated fibroblast (CAF) subtype characterized by p16INK4a expression and myofibrobl...
Online Now! Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids dlvr.it/TP2y1m #stemcells
cell.com
Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections...
The nucleus basalis of Meynert (nbM) regulates cortical function and cognition. Liu and colleagues report a method for creating human nbM organoids (hnbMOs) containing cholinergic projection neurons...
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