Paul Tesar
@TesarLab
GirlDad | Professor @CWRUSOM developing glial therapies for neuro diseases | DPhil @UniofOxford @NIHOxCam | Co-founder @convelotx | Director @riseupneo | Foodie
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So cool to see our recent paper on environmental chemicals affecting brain health on the cover of Nature Neuroscience! Congrats again to @ErinFCohn and the team. Special thanks to Ella Maru Studio @Ella_Maru for the artwork
Excited to share this excellent article by Teddy Amenabar @TeddyAmen in The Washingotn Post @washingtonpost. It provides a clear & balanced look at our recent discovery of a class of household chemicals that are harmful to the brain's myelinating cells. wapo.st/4dcYUL6
Proud to see work from our lab making its way to patients. I am hopeful that the investigational drug, ION356, being tested by Ionis will be found to be both safe & effective in people with Pelizaeus Merzbacher disease🙏 Link to our 2020 @Nature paper: nature.com/articles/s4158…
Chemicals Found In Popular Household Products Potentially Linked To Autism, Multiple Sclerosis, Study Suggests go.forbes.com/c/yXec
Thank you @EricTopol for highlighting our paper. An open access link to the full article is here: rdcu.be/dCpPr
New and worrisome: common household chemicals can directly harm oligodendrocytes, brain health nature.com/articles/s4159… @NatureNeuro @TesarLab @CWRUSOM Quarternary ammonium compounds (disinfectants) and organophosphate flame retardants implicated from organoids and expt'l models
MS and autism among brain health risks from common household chemicals newsweek.com/ms-autism-hous…
Great work by @bllclayton, @TesarLab, & the team. Such an insightful dive into modulation of astrocyte reactivity. @ScienceLemon92 and I were honored to write the @NatureNeuro N&V on this piece - see rdcu.be/dzXrM. (1/2)
Excited to share that my first postdoc publication is officially out! Combining an astrocyte cellular platform and chemical screening we identified drugs that can suppress the formation of pathological astrocytes and promote neuroprotection. thedaily.case.edu/fixing-rogue-b…
A phenotypic screening platform for identifying chemical modulators of #astrocyte reactivity reveals histone deacetylase 3 (HDAC3) inhibitors as suppressors of pathological astrocyte reactivity @TesarLab @bllclayton nature.com/articles/s4159…
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