Gwen N. Huynh
@CoderOmix
Assistant Professor Center for Translational Neuromedicine - University of Copenhagen Aspiring data scientist for a future of personalized medicine.
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Is there anything TRPV4 can't do? Our paper just out in @StemCellsJournl by Vince Willard shows that #TRPV4 is not just a marker of chondrogenesis, it also regulates it in #iPSCs! w/ Holly Leddy, Daniel Palmer, Chia-Lung Wu, & Wolfgang Liedtke @Regeneron …cellsjournals.onlinelibrary.wiley.com/doi/full/10.10…
Congrats to Dr. Dakota Katz @_NorthOrSouth on her brilliant @WashUBME PhD defense!!!! An amazing dissertation covering multiple areas of stem cells and regenerative medicine! Many thanks to her committee @mfarooqrai @SimonYTangLab @JaiRudra4 @spencelake
Happy anniversary to us! 5 years at @WUSTLmed @WUSTLortho @washu_ortho_res @washu_ortho_res @wustlcrm @ShrinersStLouis and we are so lucky to have an amazing group and network of collaborators!
A very special day for @guilak_lab – our 5 yr anniversary at @shrinerstl & @wustl_ortho! I am indebted to the members who moved here w/ @setton_lab & me - @coderomix @chialungwu @alisonkross @dryolo S. O’Connor & R. Tang. So grateful for our new group & new collaborator network.
Is obesity a disease of stem cells? We think so! Today in @CellStemCell, @ArinOestreich reviews how obesity reprograms stem cells, in utero and in adults, and how dysfunctional stem cells can contribute to obesity. w/@KelseyHCollins @naciopek @chialungwu cell.com/cell-stem-cell…
My PhD work is published! All thanks to this amazing advisor and supporter through and through @Farsh_G, and the best lab fam anyone could have ever asked for @Guilak_Lab . I miss you guys so much! Stay safe! *distance hugging*
And in some awesome news this week, 2x congrats to Gwen Huynh @CoderOmix for her GRASLAND lncRNA paper being published in @eLife and starting her faculty position at the Univ of Copenhagen!!! @washu_ortho_res @wustlcrm @WashUDevBio @WashUBME elifesciences.org/articles/49558
Congrats to Amanda Dicks and Chia-Lung Wu for their paper just out in Stem Cell Res & Ther! They used a CRISPR-based COL2A1 reporter and scRNA-seq to identify triple-positive cells for CD146, CD166, and PDGFRB as iPSC chondroprogenitors! @amandarose_615 rdcu.be/b1SV4
Let’s all RT with a #hottopic suggestion for #ORS2021. I’ll get the ball rolling. #hottopic 1 - machine learning in orthopaedic. #hottopic 2 - spatial transcriptomics
#ORS2021 will be offering some new programming...one specific type of program will be featured HOT TOPICS. We want to hear from you what #hottopic in the field should be featured in 2021 at ORS? #share #ORSNation #wearelistening #orthopaedics #musculoskeletal #science
Our new preprint is out on @biorxivpreprint - great work by Gwen Huynh @CoderOmix using scRNA-seq and LRLR to deconstruct the inhomogeneity of human bone marrow MSC chondrogenesis! w/ @NatKellyPhD @_NorthOrSouth and great collaboration with Minh Pham lab. biorxiv.org/content/10.110…
This is a cool preprint for any scATAC-Seq folks!
So you got an exciting scATAC-seq dataset and you want to know which method you should use to analyze it right? We had the same question so we decided to try them all! Read our preprint on benchmarking methods for featurization and clustering here: biorxiv.org/content/10.110…
Check out the great comic by @jorgecham on the computational tissue engineering work we're doing in our team! @GIGA_ULiege @leuvenresearch
Excited for a new preprint today led by Amanda Dicks & Chia-Lung Wu! Using our CRISPR-generated reporter iPSC line, they identified cell surface markers that define chondroprogenitors and showed by scRNAseq that we can greatly enrich chondrogenesis. biorxiv.org/content/10.110…
Check out our latest paper (rdcu.be/bG924) showing that meniscus-derived matrix scaffolds can facilitate cellular infiltration and enhance integrative meniscus tissue repair over control tissues. @SciReports @DrYOLO15 @defratelab @Farsh_G
Join ORS' Great Lakes/Midwest Regional Symposium 8/12/19: Orthopaedic Research: Bench to Bedside, bringing together investigators to present, experience unique exchanges, sessions & networking. Submit your abstract! ors.org/great-lakes-sy… #ORSAmbassador #ORSChicago
Key words: "or 3..." lol
In case you've not been keeping track, that's 2 preprints, 1 paper, and 1 special issue of Journal of Orthopedic Research in the past 2 weeks. Also a grant or 3 submitted...
One more preprint from @guilak_lab on @biorxivpreprint! Our single-cell RNAseq atlas of limb bud development in the mouse. Fantastic work by Natalie Kelly @NatKellyPhD, with Gwen Huynh @CoderOmix. biorxiv.org/content/10.110…
Our new paper (not preprint!) in collaboration with Benny Larson & Lisa Freed in the Langer Lab is out in JTERM showing how different culture conditions and proximity to bone influences chondrogenic, hypertrophic, or osteogenic differentiation of MSCs. onlinelibrary.wiley.com/doi/abs/10.100…
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