Bode Lab
@HelgeBode_Lab
Run by members of the Bode Lab. Doing all things related to natural products.
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Happy to announce the first steps into NRPS/PKS engineering thanks to the work from Leonard and collaborations with the labs from Markus Kaiser and Michael Groll: Bioengineering of syrbactin megasynthetases for immunoproteasome inhib... sciencedirect.com/science/articl…
Leonard has applied the XUT NRPS engineering technology to solve the biosynthesis of the potent antibiotic odilorhabdin in collaboration with the Rolf Müller lab at @Helmholtz_HIPS. See his paper in @angew_chem: doi.org/10.1002/anie.2…
CRISPR now also available for Xenorhabdus and Photorhabdus for easy access to natural products and manipulation of their biosynthesis: Please see the paper from Alexander in Microbial Cell factories: rdcu.be/dDibN
And here is another cool story about trans-AT PKS engineering in the same issue science.org/doi/10.1126/sc… from the @piel_lab. Congratulations!!
Finally! After a long journey our latest NRPS engineering story is out at science.org/doi/10.1126/sc… thanks to the hard work of several members from the @HelgeBode_lab
With our newest preprint on engineering NRPS we succeeded in optimizing our first-of-its-kind biocombinatorial technology. Read more here: Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases biorxiv.org/content/10.110…
The latest update for NRPS engineering, based on a evolutionary breakpoint within thiolation domains is out: doi.org/10.1101/2022.1…
Next round in "the many things that regulatory RNAs can do" - this time: controlling natural-product synthesis. Fantastic collaboration with the Bode lab (@HelgeBode_Lab) published today in @NatureMicrobiol nature.com/articles/s4156…
An awesome addition to polyketide biosynthesis. TE disguises itself as KS catalyzing branched polyketide formation. Read about Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A pubs.acs.org/doi/10.1021/ja…
pubs.acs.org
Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide, Gregatin A
Gregatin A (1) is a fungal polyketide featuring an alkylated furanone core, but the biosynthetic mechanism to furnish the intriguing molecular skeleton has yet to be elucidated. Herein, we have...
Luckily, despite severe jet lag, Helge’s given a clear, nice talk @SIMB_Microbio #NaturalProducts on NRPS engineering with a more efficient approach. Showing the advantages of artificial docking domains in splitting and reconstructing the megasynthetases
Finally... more than a module! Great NRPS work from the Schmeing lab: Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility science.sciencemag.org/content/366/64…
Who makes antibiotics and how do NRPS work? See the Grininger/Bode group performance for kids here: rz.uni-frankfurt.de/68128012/Kinde…
🤔 could have submitted more
JOC invites you to take a look at this Note from first-time corresponding author Helge Bode & coworkers: (±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 dx.doi.org/10.1021/acs.jo…
We have new, hypermodified peptides for you! Check out our aeronamide (from Microvirgula) & polygeonamide (from deep-rock metagenome🤘🎸) story at @NatureChemistry nature.com/articles/s4155… #RiPPs
Natural products go RNA: The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation cell.com/cell-chemical-…
Read Jörn‘s @nature #behindthepaper on how we developed the TransATor, a web tool for de novo structure predictions of trans-AT polyketides & why you need it go.nature.com/2jL18eL
The long-awaited TransAtor paper is out in @nchembio! TransAtor is a web application enabling de novo structural predictions of trans-AT PKS-derived polyketides. nature.com/articles/s4158…
First time to achieve peptide ligation in water, offering a chemical perspective of chicken-and-egg problem for the origin of life nature.com/articles/s4158…
Nice work by the Stanley-Wall lab: Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm pnas.org/content/116/27…
Tom's amazing @NatRevChem review is finally out!! Learn more about hidden #enzymology, unprecedented chemistry & new approaches for exploring microbial dark matter at #naturalproducts nature.com/articles/s4157…
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