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📢 A novel gene therapy for #Dravet. jci.org/articles/view/…. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.
Excited to share our new paper in @FEBSJournal! 🎉 We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation 🔗 doi.org/10.1111/febs.7… @peterslab1 @TAUMedFaculty
🚨New preprint alert! Wonder how a cancer-associated mutation in GGPPS impacts hexameric stoichiometry, substrate affinity, and product inhibition? Our results shed light on a novel regulatory mechanism in protein prenylation bit.ly/3ZR7w47 #MultipleMyeloma
Congratulations!! 🥳🥳
How does a cytoplasmic enzyme make a membrane product? 🤔🧬 We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane! MD simulations + fluorescence = mechanistic insight 👇 🔗doi.org/10.1002/pro.70…
Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…
💖Love, Science & the Brain💖 This #ValentinesDay, meet Profs. Moran Rubinstein & Yoni Haitin - a couple bonded by love & a passion for #neuroscience. From BSc to leading labs, their journey is proof that great discoveries are made together. 🔬 Read more: linkedin.com/feed/update/ur…
Congratulations 🎊🎈🎉!
The New Dravet syndrome mouse model sheds light on the disease! This research by Prof. Rubinstein & collaborators uses a more accurate mutation to study Dravet & its causes: frontiersin.org/articles/10.33… #epilepsyAwarenessDay #DravetSyndrome @FrontiersIn #EpilepsyAwareness
Happy to share our new collaborative paper exploring the molecular basis of DEE-related #SCN8A mutation 🍾 | Work led by @QuinnShir with Yuanyuan Liu, @roybensh, @HaitinLab 🥰, Haim Bassan #epilepsy surl.li/rvzbw
Have you ever thought that chloride intracellular channel (CLIC) proteins function as fusogens? 🫧 From 🧪&💎 to 🪱 we're happy to share our recent paper showing just that! nature.com/articles/s4146…
Three days full of sodium channel talks. Cant wait for it to start! See many of you in Grindelwald!
Very soon, we will start the first and unique Worldwide Sodium Channel Conference in the Alps #Grindelwald #Switzerland. The final program is out sodiumchannelseminars.org/Sodium-Channel… Want to know how much snow we have? Here is the webcam: jungfrau.ch/fr-ch/live/web… #IonChannels #SodiumChannels
Dravet syndrome is a devastating form of epilepsy that can strike before an infant’s first birthday. Researchers at the Allen Institute and @SeattleChildren are developing a precise gene replacement therapy that has shown promising results in mouse models. biorxiv.org/content/10.110…
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