The Shah Lab
@LabShah
This is the web presence of the Shah lab. We fight tuberculosis by understanding the people who are at highest risk for developing it.
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We found that a tuberculosis resistance protein protects from alveolar macrophage necrosis by controlling lipid accumulation and the integrated stress response. @NatureMicrobiol #TB rdcu.be/dCnCc
Diminished Mycobacterium tuberculosis-specific T cell responses during pregnancy in women with HIV and receiving isoniazid preventive therapy ✅ Just Accepted ✍️ @LabShah 🔗 bit.ly/4jKd75B
"The integrated stress response (ISR) enables cells to cope with insults...we identify time- and dose-dependent gene expression modules, with ATF4...rerouting carbon utilization towards amino acid production & away from the TCA cycle and FA synthesis." nature.com/articles/s4146…
Really cool paper on the effects of SCFA with macrophage inflammation.
Glad to share our recent work on the reprogramming of resolving monocytes capable of inter-cellular propagation of immune-homeostasis and reducing atherosclerosis. ahajournals.org/doi/10.1161/CI…
Glad to share our recent work on the reprogramming of resolving monocytes capable of inter-cellular propagation of immune-homeostasis and reducing atherosclerosis. ahajournals.org/doi/10.1161/CI…
New study from us! 😀 Using quantitative proteomics led by @JinLi33877470, we found evidence for mitochondrial protein misfolding in human islets in T2D that led us on our first journey into proteostasis! Feedback desired and appreciated! biorxiv.org/content/10.110…
We are strangely moved to be back home in Chicago after so long. Looking forward to a great time reconnecting with colleagues at #AAI2024
Interested in doing a postdoc in Seattle? Join us May 7 for Seattle DROP, a virtual biomedical postdoc recruitment event. The first 250 US registrants enjoy lunch via delivery voucher! Underrepresented candidates are esp encouraged to attend. Register: bit.ly/seattledrop
Time to ditch @BioRender? I had no idea they were claiming copyright to the figures we make with it, even after we pay for use of the service.
Take a look at our latest TB article by @LabShah showing the mechanistic basis for why TOLLIP deficiencies increase severity of Mycobacterium tuberculosis infection nature.com/articles/s4156…
nature.com
TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to...
Nature Microbiology - Toll-interacting protein (TOLLIP) prevents inflammation and lipid accumulation in alveolar macrophages to limit integrated stress response activation, macrophage necrosis and...
Are you on the West Coast? Do you work on TB? Come to the PacTB meeting in May! seatrac.uw.edu/training/pactb
Opinion: I'm an American doctor who went to Gaza. I saw annihilation, not war - Los Angeles Times latimes.com/opinion/story/…
I am still looking for postdocs to join my lab. I have several NIH-funded positions to work either on Acinetobacter pathogenesis or OMV biogenesis in Bacteroides. Please RT.
The Shah lab is hiring! Looking for talented postdocs interested in mucosal immunology and genetics: apply at this link ap.washington.edu/ahr/position-d…
Hi! We made an interesting observation -- variants in MUC5AC, an induced barrier mucus in lungs and gut, significantly influences TB meningitis outcomes. Read Michelle's paper just out in JID. Thanks to all our collaborators who helped us with this work. academic.oup.com/jid/advance-ar…
Please help @UWMedicine & @UWSPH find a dynamic Chair of the Department of #GlobalHealth that makes a difference in the world 🌏🌍LI post is shareable linkedin.com/posts/uwsomwwa… 🌍More info and apply at apply.interfolio.com/119348
To kick off the new year checkout our recent study @Nature highlighting the essential crosstalk between neonatal neutrophils and AM nature.com/articles/s4158… A big shout out to brilliant @erwan_pernet and the entire team collaborators @LB_Barreiro @AjithaT4 and Yipp-lab
We are looking for a #postdoc in host-pathogen interaction and innate immunity! Projects include #trainedimmunity #interferons #humanizedmice #alveolarmacrophages #lung. @RutgersU @Rutgers_NJMS @RutgersBHS
Most recent work from the lab just out @Nature. By combining ancient DNA work, population genomics, and in vitro infections we show that the Black Death shaped the evolution of immune genes. Kuddos to co-first authors @TaurVil and Jennifer Klunk. nature.com/articles/s4158…
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