Dylan Ryan
@RyanLab_TCD
Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. 🦋 @ryanlab.bsky.social
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Very excited to announce that the first paper from the lab is now live @NatureComms #mitochondria #immunometabolism This work was led by postdoc @EloiseMLMrqs with many important contributions from all of our co-authors. New insights since the preprint (summarised below): 1)…
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. elifesciences.org/reviewed-prepr…
In @NatureMedicine from @kaelin_lab Targeting of HIF2-driven cachexia in kidney cancer nature.com/articles/s4159… A common mediator for cancer associated cachexia between #RenalCancer & #PancreaticCancer (PTHrP, encoded by HIF2 responsive PTHLH gene)! @PitarresiLab
#NoTimeToDie! Welcome mitoxyperiosis! @ThiruKanneganti Wang &co show @CellCellPress that carbon starvation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria driven membrane oxidative damage cell.com/cell/abstract/…
CORRESPONDENCE | M Vigneau, JP Pradère et al. (U Toulouse): EMito-Metrix enables automated evaluation of mitochondrial morphology across species nature.com/articles/s4225…
Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus dlvr.it/TPSYVn
Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway. embopress.org/doi/full/10.10…
📢Last 2 weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️ biomed.news/bims-imicid/20… biomed.news/bims-imicid/20… Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
🚨 Thrilled to see our work published in @NatMetabolism 🚨 Huge thanks to @Dr_LPJ Jametti and his team. Delighted to collaborate on neuroimmune interactions at the crossroads of microglia, cell metabolism, and complex brain functions. nature.com/articles/s4225…
RESEARCH | Y He, JZ Long, Y Xu et al (Baylor Medicine, Stanford): This study reveals neuronal targets of Lac-Phe in the hypothalamus that mediate its suppression of food intake. nature.com/articles/s4225…
Excited to share our study @CellCellPress introducing a novel class of macrophage-targeted immunocytokines (MiTEs) that engage myeloid, T and NK cells to boost anti-tumor immunity in solid tumors. Led by @MVLocquenghien, @PascaleZwicky & @CuriousKX (1/16) cell.com/cell/abstract/…
New paper: in which we show there's really no evidence for a link between the gut microbiome and autism cell.com/neuron/fulltex…
I've been reading @matthewcobb's new biography on Francis Crick. It contains many surprises, especially regarding the solving of DNA's structure. I finished reading through 1953. Here my notes so far: 1. Photograph 51 was not taken by Rosalind Franklin. It was taken by Raymond…
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy nature.com/articles/s4158…
Stanford Medicine investigators and their colleagues have found that one of humanity’s most ubiquitous infectious pathogens bears the blame for lupus, the chronic autoimmune condition. med.stanford.edu/news/all-news/…
Sickness engrams modulate anticipatory immune responses biorxiv.org/content/10.110…
Cover article of @Cell_Metabolism by @KivancBirsoy @RockefellerUniv is a fitting tribute to NYC skyline & our subway map! Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis cell.com/cell-metabolis…
Article "Comparison of immunometabolic profiles in whole blood versus peripheral blood mononuclear cells" by @EvertsBart team journals.lww.com/immunometaboli…
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