Parham Lab
@ParhamLab
@StanfordMed Studying the biology, genetics and evolution of the Major Histocompatability Complex (MHC) and other immune molecules.
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Amazing paper by Dr Emily Wroblewski on Malaria-driven adaptation of MHC class I in wild bonobo populations - read it here! nature.com/articles/s4146…
Very excited to say our paper exploring CD56neg NK cells has been published! Through a combination of meta-analysis, and both CyTOF and scRNAseq datasets, we investigate this unique population of NK cells linked to HIV-1 and other chronic virus infections frontiersin.org/articles/10.33…
New paper with @PN0rmski, Gabriel Santpere, @ArcadiNavarro, and @MarcoTelford. Does peptide-specific immune recognition shape herpesvirus protein diversity? pnas.org/doi/full/10.10…
#JI_TopRead: From researchers @stanfordimmuno @ParhamLab @PN0rmski @HLAB8 | Following Transplantation for Acute Myelogenous #Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01 #ReadTheJI ow.ly/R7pI50FqoGn
Our latest release: HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity. @DjaoudZ. annualreviews.org/doi/abs/10.114…
annualreviews.org
HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity
In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a peptide and take it to the cell surface for surveillance by lymphocytes. These include natural killer (NK)...
Our latest release from @DjaoudZ 'Dimorphism in the TCRγ-chain repertoire defines 2 types of human immunity to Epstein-Barr virus' bit.ly/2UDBcjH
Here’s our new paper — On genetic diversity in the human immune system — five years of research, led by postdoc @pippa_kennedy, and many collaborators. In @scisignal stke.sciencemag.org/content/12/612…
Natural Killer cell research in @scisignal ? Well isn’t that just a perfect Xmas present!
The new issue of Science Signaling is out now! Research explores how a cancer drug attenuates lung fibrosis in mice, how a common chemotherapy can promote cancer cell migration, and genetic diversity in natural killer cell receptors. fcld.ly/xmb5hdo
Enhancing NK cell missing self responses with in vitro education by KIR3DL1. Our latest paper out now in @LSAjournal life-science-alliance.org/content/2/6/e2…
Altfeld and colleagues identify the NK cell receptor NKp44 as directly interacting with the class II HLA-DP in a partially peptide-dependent manner and with functional consequences for NK cell activity go.nature.com/2YzxEPD
Report from the Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop: novel insights on KIR polymorphism, ligand recognition, expression and f... - PubMed - NCBI Hoping to attend the next one in 2020, hosted by @PN0rmski ncbi.nlm.nih.gov/pubmed/3117763…
Our new perspective on the exciting research from @mjwsim and others, an encouraging step for identifying orphan KIR ligands and a role for NK cells in defense against bacterial infection.
A natural killer cell receptor takes sharp aim at the world of bacteria. dlvr.it/R6JT06
Review on how population genetics can greatly inform questions in human immunology @CellCellPress, see cell.com/cell/fulltext/…... and a great Cell's 2019 Special Issue: Unraveling the Human Genome! See cell.com/cell/issue?pii…
Our latest paper in collaboration with @PN0rmski and others out now, KIR and HLA class I diversity in Sub saharan African populations, 28 novel KIR alleles but surprisingly no new HLA alleles bit.ly/2OtRMiC
Super excited to see our paper finally out today @PNAS! A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson’s disease pnas.org/content/early/…
Our new review with Dr Emily Wroblewski is out now, studying Hominid species to understand 'the evolutionary dance between two cooperating systems of MHC class I and NK cell receptors' bit.ly/2Xg81Uw @WUSTLbioanthro
**🚨 NEW PRE-PRINT🚨 ** So excited to share our work on KIR2DS4!!!! #NKcells #immunology #HLA
HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor biorxiv.org/cgi/content/sh… #biorxiv_immuno
1/x. NK cell education is tightly linked to remodelling of the lysosomal compartment. Educated NK cells carry a greater cytotoxic payload in large dense-core secretory lysosomes (See T shirt). rdcu.be/bjoz0 @jodegoodridge @CIM_Sweden @UiO_LifeSci @NatureComms
Thanks to Christina Tato @chanzuck biohub for very nice highlight of my 2013 CyTOF study with @ParhamLab and Catherine Blish published @NatRevImmunol. 1st report of human NK cells by CyTOF. nature.com/articles/s4157…
Wow! So nice to see that the complex genetics of NK cell education revealed by @AmirHorowitz has a role in AML and Immunotherapy. Makes perfect sense!
Read our latest paper on how the HLA-B -21 dimorphism impacts on NK cell function in AML! @thoren_lab @Hallner90 @hussein_brwa #NKcell bloodjournal.org/content/early/…
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