Zepeng (Phoenix) Mu
@ZepengMu
(牟泽鹏) Postdoc @soumya_boston @BrighamWomens @broadinstitute | PhD @yang_i_li @UChicago | BS @UCAS1978 | Twin @charlie_z_mu
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So excited to share our latest with Betty Diamond and many colleagues from the AMP RA/SLE consortium, @NIH_NIAMS , and @NIAIDNews ! A large-scale blood and tissue atlas of Lupus Nephritis! biorxiv.org/content/10.110…
I am very excited to share our publication, out now in Nature, detailing our developed CRAFTseq methodology for capturing and analysing single cell genomic DNA amplicons alongside the transcriptome and cell surface protein expression. nature.com/articles/s4158…
Join me for this lecture to find out how we use genomics to decipher #autoimmunity and #rheumatoid arthritis
Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA – or online – for a Broad Discovery Series talk with @soumya_boston: “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySerie… #ScienceTalks
📣Excited to share my last postdoc paper with @soumya_boston on eQTL mechanisms depending on where the RNA is in the cell! @BrighamResearch @broadinstitute TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵👇
Early and late RNA eQTL are driven by different genetic mechanisms biorxiv.org/content/10.110… #biorxiv_genomic
My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen
Our work is out in AJHG! I wholeheartedly thank all the co-authors @marie_saitou @andywdahl @qbw_128 for their time and effort! All four of us started our own labs between 2019 and 2021 and the pandemic didn't make things easy. Super proud of everyone.
📢Online now! 📰Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines 🧑🤝🧑@marie_saitou @XuanyaoLiu & co cell.com/ajhg/abstract/…
Our work on trans regulation of proteome and how protein-protein interactions play a role in it🧬.
🚨New Preprint Alert: Our work led by @JinghuiLi14637 is up on bioRxiv. We re-analyzed large maps of trans-pQTLs, and found that protein–protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits. A brief thread🧵👇
check out our review discussing immune diversity through the lens of evolutionary biology! we argue that past selection underlies variation in disease risk across populations and offer new avenues to pursue that couple empirical and genomics approaches shorturl.at/ghMO9
Our work led by @liliw_wang on identifying trans genetic effects of gene networks is out in @CellGenomics today!
Trans-eQTL mapping in gene sets identifies network effects of genetic variants dlvr.it/T4w67y
CRISPR editing is hard. Editing in primary human cells is even harder. Editing non-coding variants in human cells is downright impossible. I am happy to share our work aimed at addressing this problem with @soumya_boston @broadinstitute @MassGenBrigham biorxiv.org/content/10.110…
Very interesting and impressive work! Congrats to my friend Wenhe!
Our paper is out in @CellGenomics! Huge thanks to all the collaborators for making it possible! cell.com/cell-genomics/…
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