Richard Wheeler
@Zephyris
Parasite cell biology, science and microscopes (with a garnish of computers, graphics and graphic design). Runs a research lab in the University of Edinburgh.
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tryptag.org update now done... Now with gene annotations from the latest genome, better links to source data (on BioImage Archive ebi.ac.uk/biostudies/Bio…), fixed missing images, and better cell cycle stage examples (selected using github.com/zephyris/trypt…).
I'm working on some server changes for tryptag.org, you might see missing data (particularly missing images)... But don't worry, it will all be up again soon!
After a hiatus, the discoba lineage-optimised Alphafold2 structure predictions are back up! Get your improved Trypanosoma and Leishmania structure predictions here. Try out the Google Colab iPython notebook (and let me know if you have any problems) colab.research.google.com/github/zephyri…
The One Health Research workshop ends with a closing ceremony and certificate presentation for the first-year MPhil and PhD students. Congratulations to all participants for their active engagement and dedication throughout the workshop! And a big thank you to all the…
Please consider applying for this post doc position in our lab if you have excellent bioinformatics and wet lab skills, and are interested in parasites! elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…
elxw.fa.em3.oraclecloud.com
Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite...
A new paper from @HymanLab @Zephyris reports that a small molecule lipoamide dissolves stress granules by targeting SFPQ, a redox-sensitive disordered protein, benefiting ALS models nature.com/articles/s4158…
Having spent an afternoon developing some models with Google AI Studio, Ted Chiang seems more prescient than ever. It's only about a page, worth reading right now! nature.com/articles/35014…
nature.com
Catching crumbs from the table
Nature - In the face of metahuman science, humans have become metascientists.
This project wouldn't have been possible without the inputs from the expertise at @dewpoint_tx, and proves intrinsically disordered domains as a small molecule target nature.com/articles/s4158…
“It’s sad if someone spends four years researching and publishes a paper and then has a figure that is not fully understandable. It will reduce the readership.” @Sara_Reardon talks with @MicrobiomDigest @HelenaKJambor @Image_Integrity. go.nature.com/4m9J20x
Small molecule targeting intrinsically disordered protein domains to help neurodegeneration, really great to finally have this collab with @HymanLab out! nature.com/articles/s4158…
Chipping away at mysteries of parasite swimming. How do proteins at the base of the flagellum control beat waveform which start at the tip? nature.com/articles/s4146…
Sorry tryptag.org tiff downloads aren't working - the server had a hard drive failure. We're looking into it. In the meantime all raw tiff images are available via here zenodo.org/records/7719295 or using github.com/zephyris/trypt….
Thrilled to be part of this exciting project on Leishmania and Crithidia doublet microtubule structures. Thanks to my two amazing PIs @RuiZhangWUSTL @PolinaLishko and our fabulous collaborators @alanbrownhms lab, @Gluenzlab lab, and @Zephyris lab🎉🎉🎉
Another wonderful collaboration with @alanbrownhms lab. The Zhang lab together with @PolinaLishko lab (co-first author @QingweiN) contribute the doublet microtubule structure from Crithidia fasciculata, a model organism that infects mosquitoes. science.org/doi/10.1126/sc…
“Collectively, the AI search engines provided incorrect answers to more than 60% of queries.” ~ @CJR 🔗 cjr.org/tow_center/we-…
Exciting day for parasite flagellar biology! science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…
Just reviewed a paper and one of the other reviewer's comments were clearly AI generated... Anyone seen that before?
🧵 Have you heard of leishmaniasis? This neglected tropical disease affects 700,000 to 1 million people each year, mostly in low-income communities. It’s caused by Leishmania parasites, spread by sandflies. It has three main forms ⤵️ [1/6]
Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York! @UniOfYork @YBRI_UoY @BiologyatYork Please RT! jobs.york.ac.uk/vacancy/postdo…
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