Adith Arun
@aditharun_
md candidate @yalemed, writing at http://aditharun.com, prev @delfidiagnostic @ibmresearch and math @johnshopkins
Was dir gefallen könnte
Before figuring out how to play a game, figure out if you should even bother playing the game. A numerical example using Ballmer's question to interview candidates at Microsoft. Consider the numbers 1 to 100 inclusive. You get six guesses to guess the number I picked on this…
You can make the numbers say whatever you want. Numbers lie. Its the explanation, method, intuition, incentives and integrity behind the numbers that matter.
Most correlations are not causal. Public health advice provides us with plenty of examples to understand 'Why?' Consider sugar. It's notably declined as a share of the American diet ever since dietary recommendations went out against it. The people who adopted the advice to…
Magic happens at 36 weeks. If you subset your study group into increasingly smaller slices, you will see a greater treatment effect. Presentation today by $AVXL at 35th Alzheimer Europe Conference ‘Connecting Science and Communities: The Future of Dementia Care’…
Seeking wisdom from Darwin to Munger George Soros: A life in full Breakneck: China's quest to engineer the future Things hidden since the foundation of the world The lessons of history A mathematician's apology Alchemy of Finance The wires of war Dark side of valuation Valuation:…
Remember lemonade, appian, redfin, zillow, spacs during the 2021 bubble… they all crashed specularly and lots of people lost a lot of money on them. A select few companies that rallied hard in that bubble (like shopify) have reached or surpassed their bubble height but it took…
Getting rid of cancer in mice is remarkably easier than doing it in humans Takeda stopped CAR-NK program after ph1/2 data Fate therapeutics CAR-NK shut down in 2023 Nkarta shut down CAR-NK in 2024 Cellularity stopped recruitment for ph1/2 CAR-NK program in 2023 Many CAR NK…
MIT and Harvard scientists have created engineered CAR-NK cells that can hide from the immune system and more effectively destroy cancer. "The cells are designed to suppress immune rejection signals and enhance tumor killing power. Tested in humanized mice, they wiped out cancer…
Munger had an almost complete indifference to problems. Troubles should be expected, they are an inescapable part of life, so why let it bother you? Handle them and move on. h/t david senra’s reflections on his dinner with Munger
This historical piece by Akira Endo, the father of statins, is a wonderful read. Clinical development for compactin (the first statin) was discontinued because it was appeared to cause lymphoma in dogs when given at > 200x the effective dose. We were close to having never having…
Statins are amazing in many ways. They've saved countless lives, and we almost didn't get them because the team that discovered them tested on one of the people who had a bad reaction. If they didn't continue testing in secret, heart disease would be much more common today!
In life, the challenge is not so much how to best play the game but to figure out what game to play Belief comes before results Beautiful.
Daniel Ek announces that he is stepping down from Spotify three days after his episode on @davidsenra’s new podcast airs (and David’s inaugural episode of the new podcast)…. Interesting. I haven’t listened to it yet (soon) but the transcript headings are so intriguing. Wonder…
The idea of using biological/medical datasets to make discoveries that can positively impact patients has driven my work from outcomes to genomics. I never got to meet Atul Butte, but read much of his work and was certainly inspired from afar. I remember reading his…
Actions reveal personal preferences and incentives. Words don’t except when talking about someone else. Disliking/liking a person and the reasons for it reveal how they see the world. It has little to do with the person they are talking about. A great example is asking someone…
5 ways to enable American insurance companies to pay for gene therapies: 1. Manufacturers lower the price of gene therapies There is a price, for each patient, such that the cost of the treatment today equals the present value of the expected costs of treatment/hospitalization…
Gene Therapy Should Not Be a Luxury - BioSpace biospace.com/drug-developme…
Announced today: Evolocumab (PCSK9i) met both primary endpoints (time to first CV event, time to CV event or ischemia-driven arterial revascularization) in VESALIUS-CV. Amgen positioning PCKS9i + lipid lowering therapy as the basis for primary prevention of CV disease. This…
A great problem for AI models is discovering new antibiotics that work on multi-drug resistant (MDR) bugs. Most patients with MDR bugs or sepsis requiring ICU care are on 'hard' antibiotics (e.g., cefiderocol, colistin, tobramycin, etc.). Hard because they are hard on the body…
Has good news been announced for any public biotech company when they guided for a specific quarter, missed that deadline completely, and did not put out any release/commentary offering an explanation or postponement? Re: $ovid q3 ph 1 topline
Daniel Ek announces that he is stepping down from Spotify three days after his episode on @davidsenra’s new podcast airs (and David’s inaugural episode of the new podcast)…. Interesting. I haven’t listened to it yet (soon) but the transcript headings are so intriguing. Wonder…
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