CD8 T engage tumor cells in antigen presentation molecule-rich pockets termed CRATERs that expand & breach tumor mass from the stromal compartment, as major site of tumor killing during treatment @CellCellPress @aya_ludin cell.com/cell/fulltext/… @leonard_zon @BostonChildrens
CircRNA: Unlocking New Frontiers in Therapeutic and Vaccine Development dlvr.it/TNkYl0 #genetherapy #celltherapy
How can we computationally design new peptides that activate T cells against cancer and viruses?@UW @PNASNews "T cell receptor specificity landscape revealed through de novo peptide design" • T cells recognize pathogen-derived peptides presented on MHC molecules through T…
Our new review in @natBME is out! RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits. free to read 🔗 rdcu.be/eLxGs
Can machine learning predict which antibodies will be structurally flexible versus rigid in their binding regions?@NatMachIntell @UniofOxford "Predicting the conformational flexibility of antibody and T cell receptor complementarity-determining regions" • Antibody…
Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics: nature.com/articles/s4155…
Learning the language of T cell receptors through large-scale screening cell.com/cancer-cell/ab…
This week's issue of #ScienceTranslationalMedicine has arrived! New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. scim.ag/43lkZUm
Nature research paper: A vaccine central in A(H5) influenza antigenic space confers broad immunity go.nature.com/4ncE8ix
Out Now! Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses bit.ly/3W7yNhr #Influenza #H5N1 #MonoclonalAntibodies
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors @CellRepMed 🇨🇳 cell.com/cell-reports-m…
DART aims to reprogram tumor cells into dendritic cells using RNA vectors to improve patient response to immunotherapy. This approach has solid benefits safety, scalability, price & customized nature. Stay connected & follow development of our strategy for cancer immunotherapy!
I will also write a Substack and X article on this. Link to the paper: science.org/doi/10.1126/sc…
Crazy example of Chinese biotech cycle times: I'm reading a new bioRxiv preprint from a Chinese research team about a new circular RNA modality. It's about a cool idea to embed aptamers into circular RNAs. The circularity confers stability and the aptamers confer targeting. So…
Replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge science.org/doi/10.1126/sc… @ScienceTM @hdtbio @IRPatNIH 🇺🇸
mRNA-Based Designer APCs Elicit Robust CD8⁺ and CD4⁺ T Cell Responses biorxiv.org/content/10.110… #biorxiv_immuno
In the latest issue! Highly conserved Betacoronavirus sequences are broadly recognized by human T cells dlvr.it/TNTw7n
Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells @biorxivpreprint @vanGilsLab @AnjaBrinke @amsterdamUMC 🇳🇱 biorxiv.org/content/10.110…
Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma @CellReports @KellyOlinoMD @ishizukalab @Yale 🇺🇸 cell.com/cell-reports/f…
Hybrid nanoparticles enhance mRNA delivery by “tricking” cancer cells into actively transporting therapeutics into the cytoplasm @PriyabrataMuk20 @OUHealthScience @ScienceAdvances science.org/doi/10.1126/sc…
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