Our @NatureNano paper is out! 📄 rdcu.be/eNf4e We built a programmable mRNA 🧬 platform that can be customized to induce tumor-selective immunogenic cell death with minimal toxicity, turning cold tumors hot and sensitizing them to immunotherapy. 🎯@UofTNews @UHN
Cross-competition shapes CD8+ T cell hierarchies and differentiation after RNA vaccination biorxiv.org/content/10.110… #biorxiv_immuno
Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections @natBME 🇨🇳 nature.com/articles/s4155… nature.com/articles/s4155…
New recipe improves creation of cells that could fight most autoimmune diseases @ScienceMagazine Nobel laureate makes regulatory T cells that last longer in the body, boosting clinical hopes science.org/content/articl…
🚨Our new paper is out today in Nature! We show that SARS-CoV-2 mRNA vaccines can sensitize tumors to immune checkpoint blockade (ICI) — revealing that clinically available RNA vaccines may act as potent immune modulators. nature.com/articles/s4158…
What? This is huge for in vitro directed evolution
環状DNA特異的にセルフリー転写翻訳されたタンパク質が自身のDNAに提示される現象を発見。 新ディスプレイ技術ICED (Intra-Circular Expression and Display) として報告しました | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…
In PBMC samples from 3x SARS-CoV-2 mRNA-vaccinated individuals, Kocher and Drost et al. used spike-specific dextramers to enrich CD8+ T cells for single-cell multiomics bit.ly/4n5mr4s @UniFAU
Fighting fungal infections with immunotherapy dlvr.it/TNnq4d #genetherapy #celltherapy
Harvard releases their research courses for free. Most people don't know these exist. Here are 6 courses to rival expensive grad programs:
CD8 T engage tumor cells in antigen presentation molecule-rich pockets termed CRATERs that expand & breach tumor mass from the stromal compartment, as major site of tumor killing during treatment @CellCellPress @aya_ludin cell.com/cell/fulltext/… @leonard_zon @BostonChildrens
CircRNA: Unlocking New Frontiers in Therapeutic and Vaccine Development dlvr.it/TNkYl0 #genetherapy #celltherapy
How can we computationally design new peptides that activate T cells against cancer and viruses?@UW @PNASNews "T cell receptor specificity landscape revealed through de novo peptide design" • T cells recognize pathogen-derived peptides presented on MHC molecules through T…
Our new review in @natBME is out! RNA-loaded lipid nanoparticles (LNPs) have huge potential—but their strong liver and immune cell uptake has mostly confined them to vaccines and liver therapies. We explore how to move beyond those limits. free to read 🔗 rdcu.be/eLxGs
Can machine learning predict which antibodies will be structurally flexible versus rigid in their binding regions?@NatMachIntell @UniofOxford "Predicting the conformational flexibility of antibody and T cell receptor complementarity-determining regions" • Antibody…
Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics: nature.com/articles/s4155…
Learning the language of T cell receptors through large-scale screening cell.com/cancer-cell/ab…
This week's issue of #ScienceTranslationalMedicine has arrived! New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. scim.ag/43lkZUm
Nature research paper: A vaccine central in A(H5) influenza antigenic space confers broad immunity go.nature.com/4ncE8ix
Out Now! Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses bit.ly/3W7yNhr #Influenza #H5N1 #MonoclonalAntibodies
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors @CellRepMed 🇨🇳 cell.com/cell-reports-m…
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