Chotiwat Seephetdee
@cseephetdee
a biochemist (by training)
A natural compound revitalizes the aging human immune system nature.com/articles/s4358…
RNA stability enhancers for durable base-modified mRNA therapeutics go.nature.com/4opTAsV
Viral vectors displaying peptide-MHC are versatile tools for activating and reprogramming antitumor CD8 T cells directly in vivo @ScienceAdvances @MEBirnbaum @MITdeptofBE @kochinstitute @ragoninstitute science.org/doi/10.1126/sc…
Molecular mimicry as a driver of T cell-mediated tumour immunity dlvr.it/TP6Sd0
Mechanism by which ER junctional proteins & lysosomal activity cooperatively pattern secretome mRNA translation, linking ER architecture and nutrient sensing to the production of secretory and membrane proteins nature.com/articles/s4158… @Nature @JLS_Lab
MHC class II immunopeptidomics in human phagocytes infected with Mycobacterium tuberculosis enables vaccine immunogen design and optimization science.org/doi/10.1126/sc… @ScienceTM
Journal Club-103 @Science In mRNA therapeutics, achieving stable and high protein expression has long been a major challenge. The research team developed a deep generative model that learns from large-scale mRNA sequence data as if it were a language, enabling optimization of…
Everyone has opinions. Science has evidence. 511 studies, one conclusion: Vaccines for COVID-19, RSV, and influenza save lives - safely. Truth doesn’t need volume. Just verification.
Our @NatureNano paper is out! 📄 rdcu.be/eNf4e We built a programmable mRNA 🧬 platform that can be customized to induce tumor-selective immunogenic cell death with minimal toxicity, turning cold tumors hot and sensitizing them to immunotherapy. 🎯@UofTNews @UHN
Cross-competition shapes CD8+ T cell hierarchies and differentiation after RNA vaccination biorxiv.org/content/10.110… #biorxiv_immuno
Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections @natBME 🇨🇳 nature.com/articles/s4155… nature.com/articles/s4155…
New recipe improves creation of cells that could fight most autoimmune diseases @ScienceMagazine Nobel laureate makes regulatory T cells that last longer in the body, boosting clinical hopes science.org/content/articl…
🚨Our new paper is out today in Nature! We show that SARS-CoV-2 mRNA vaccines can sensitize tumors to immune checkpoint blockade (ICI) — revealing that clinically available RNA vaccines may act as potent immune modulators. nature.com/articles/s4158…
What? This is huge for in vitro directed evolution
環状DNA特異的にセルフリー転写翻訳されたタンパク質が自身のDNAに提示される現象を発見。 新ディスプレイ技術ICED (Intra-Circular Expression and Display) として報告しました | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac…
In PBMC samples from 3x SARS-CoV-2 mRNA-vaccinated individuals, Kocher and Drost et al. used spike-specific dextramers to enrich CD8+ T cells for single-cell multiomics bit.ly/4n5mr4s @UniFAU
Fighting fungal infections with immunotherapy dlvr.it/TNnq4d #genetherapy #celltherapy
Harvard releases their research courses for free. Most people don't know these exist. Here are 6 courses to rival expensive grad programs:
CD8 T engage tumor cells in antigen presentation molecule-rich pockets termed CRATERs that expand & breach tumor mass from the stromal compartment, as major site of tumor killing during treatment @CellCellPress @aya_ludin cell.com/cell/fulltext/… @leonard_zon @BostonChildrens
CircRNA: Unlocking New Frontiers in Therapeutic and Vaccine Development dlvr.it/TNkYl0 #genetherapy #celltherapy
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