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Fantastic work by @fancaoErik and @LindorffLarsen - glad to see (a) @david_c_moses's Gly-Ser constructs put to good use for calibrating a forcefield, and (b) a coarse grained forcefield that can provide realistic ensembles of multi-domain proteins!!
Updated version of CALVADOS We show that a Calpha representation of folded domains can give rise to too compact conformations of multi-domain proteins (MDPs), and that a centre-of-mass representation of the folded domains improves agreement w experiments doi.org/10.1101/2024.0…
Our review on sensing through disorder was selected for Trends "Editor's Choice of 2023" collection! Thanks to @TrendsBiochem editor Sannie Culbertson for her outstanding work editing this piece. w/ @david_c_moses @GarrettGinell and @alexholehouse . cell.com/trends/biochem…
Our December issue is compiled! The cover depicts how the intrinsic disorder of proteins may act as cellular sensors of their #physicochemical environment (i.e. temperature, pH, redox state). @david_c_moses @GarrettGinell @alexholehouse @shaharsu cell.com/trends/biochem…
Congrats @FengYu65387524!!
Proud to present my latest preprint with my advisor @shaharsu. It shows how disordered protein ensembles structures can shape the entropic force. Happy to have the preprint online by Chinese New Year.😃😜🤪 biorxiv.org/content/10.110…
When your PI asks "Do you have new results?"
Excited to present a poster today on the structural preferences of intrinsically disordered regions and how they adapt to changes in the surrounding environment in vitro and in live cells. If you are at #bps2022, it would be great to see you there. 1553-Pos/B11
We're upping our game with a full sound system. Full set by the Intrinsic Disorders @david_c_moses, @eflores500, and @dann_navarrete1, with guest appearances by @Nora__Margaret @FengYu65387524 and Patrick.
Another cool paper from brilliant SAXS mentor @ewmartin.
Nice work on the early steps of prion-like domain phase separation by Erik Martin from my lab and a number of fantastic collaborators, including @AndreaSoranno, Peter Schuck, Tyler Harmon, staff from the BioCAT beamline.
📢This MONDAY, 2/22 @ 10AM EST!!! Joint us for the BIV subgroup meeting @bioplymrsinvivo. We have a FANTASTIC lineup, including @JLS_Lab,@Toliclab, @theJensenLab, @fried_lab, and more! Looking forward to seeing you all there!! Details: bit.ly/3sf48Oh. Please RT!!
We are happy to reveal our schedule for March/April featuring @MaleneRJensen, @Ivarssonlab, @FitzpatrickLab, @SAShowalterLab, @SpruijtLab, @LabStrader, Kausik Si, @ElisarBarbarLab, @mbuanand and Kathrine Stott. Please help spread the word! Register at: idpseminars.com.
Here we have a novel biosensor featuring a disordered protein surrounded by two fluorescent proteins. Preprint is at biorxiv.org/content/10.110…. Tweetorial is attached. Proud to have been a member of this team led by @cuevas_lab and also including @the_KarinaG and @shaharsu.
Happy to share the preprint from our work at @JoseDinneny lab. We developed a FRET biosensor that tracks the physical-chemical effects of osmotic stress on live cells using an Intrinsically Disordered Protein from Arabidopsis (1/n) biorxiv.org/content/10.110…
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