What controls whether cells - or clusters of cells - break off from an invading cancerous front? New preprint from my group in collaboration with the Konstantopoulos group @KKLabJHU , led by @wwang721 doi.org/10.1101/2024.0…
This is a really fun project - we modeled experiments from @KKLabJHU doi.org/10.1126/sciadv… - trying to capture how rates and distributions of cluster size depend on the geometry of the channel they're invading into.
We find cell dissociation depends on cell-cell adhesion, noise in cell motility, the presence of leader cells, as well as some surprises -- like cell-channel adhesion.
For physicists, we also show that there's a big difference between "jammed" and "unjammed" tissues. We find unjamming is necessary - but not sufficient - to predict the ability of cells to dissociate from an invading front.
Much much more in the paper, so I won't drag on here. Congrats to @wwang721 !
United States الاتجاهات
- 1. Kennedy Center 70.7K posts
- 2. Greg Biffle 85.9K posts
- 3. Hunger Games 41.6K posts
- 4. Seahawks 19.6K posts
- 5. Muschamp 4,487 posts
- 6. NASCAR 65.1K posts
- 7. #Cookiemas2025 N/A
- 8. Salem 15.6K posts
- 9. Jakobi Meyers 1,263 posts
- 10. Arnold 7,709 posts
- 11. Patriot Games 7,727 posts
- 12. #LightningStrikes N/A
- 13. Puka 24.1K posts
- 14. blackpink 48.3K posts
- 15. North Carolina 55.6K posts
- 16. Jim Hunt N/A
- 17. Adin Ross 5,690 posts
- 18. Parkinson 5,985 posts
- 19. James Caan N/A
- 20. Diawara N/A
Something went wrong.
Something went wrong.